{"id":"https://openalex.org/W1978720093","doi":"https://doi.org/10.1016/j.bpj.2013.11.2696","title":"A Non-Active Site Set Domain Surface that is Crucial for Di-Methylation of Histone H3 Lysine 4 by the Mixed Lineage Leukemia-1 (MLL1) Core Complex","display_name":"A Non-Active Site Set Domain Surface that is Crucial for Di-Methylation of Histone H3 Lysine 4 by the Mixed Lineage Leukemia-1 (MLL1) Core Complex","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1978720093","doi":"https://doi.org/10.1016/j.bpj.2013.11.2696","mag":"1978720093"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpj.2013.11.2696","doi":"https://doi.org/10.1016/j.bpj.2013.11.2696","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2013.11.2696","pdf_url":"http://www.cell.com/article/S0006349513039532/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0006349513039532/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024748594","display_name":"Stephen A. Shinsky","orcid":"https://orcid.org/0000-0001-5437-1729","observed_orcids":["https://orcid.org/0000-0001-5437-1729"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen A. Shinsky","raw_affiliation_strings":["SUNY Upstate Medical University, Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Upstate Medical University, Syracuse, NY, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70983195","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02","country_code":"US","type":"education","lineage":["https://openalex.org/I70983195"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Hu","raw_affiliation_strings":["Syracuse University, Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syracuse University, Syracuse, NY, USA","institution_ids":["https://openalex.org/I70983195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078035876","display_name":"Valarie E. Vought","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70983195","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02","country_code":"US","type":"education","lineage":["https://openalex.org/I70983195"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valarie E. Vought","raw_affiliation_strings":["Syracsue University, Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syracsue University, Syracuse, NY, USA","institution_ids":["https://openalex.org/I70983195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080090648","display_name":"Michael S. Cosgrove","orcid":"https://orcid.org/0000-0002-2156-7562","observed_orcids":["https://orcid.org/0000-0002-2156-7562"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S. Cosgrove","raw_affiliation_strings":["SUNY Upstate Medical University, Syracuse, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Upstate Medical University, Syracuse, NY, USA","institution_ids":["https://openalex.org/I20388574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07129602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"106","issue":"2","first_page":"477a","last_page":"477a"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4253000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.24009999632835388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.17419999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mll1","display_name":"MLL1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.7549999952316284},{"id":"https://openalex.org/keywords/set-domain","display_name":"SET domain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/kabuki-syndrome","display_name":"Kabuki syndrome","score":0.8569999933242798},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.800000011920929},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.703000009059906},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6505799889564514},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6004483103752136},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5715652704238892},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.5703729391098022},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.5324795246124268},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.46169814467430115},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.43734753131866455},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3457925319671631},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2812994122505188},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19528785347938538},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09151306748390198}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bpj.2013.11.2696","doi":"https://doi.org/10.1016/j.bpj.2013.11.2696","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2013.11.2696","pdf_url":"http://www.cell.com/article/S0006349513039532/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bpj.2013.11.2696","doi":"https://doi.org/10.1016/j.bpj.2013.11.2696","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpj.2013.11.2696","pdf_url":"http://www.cell.com/article/S0006349513039532/pdf","source":{"id":"https://openalex.org/S98085912","display_name":"Biophysical Journal","issn_l":"0006-3495","issn":["0006-3495","1542-0086"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biophysical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978720093.pdf"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1973603244","https://openalex.org/W2149321817","https://openalex.org/W2169812632"],"related_works":["https://openalex.org/W2031128646","https://openalex.org/W2012606436","https://openalex.org/W2608858781","https://openalex.org/W2036036824","https://openalex.org/W2008625770","https://openalex.org/W63928266","https://openalex.org/W191288134","https://openalex.org/W2338114044","https://openalex.org/W4389019446","https://openalex.org/W1908801040"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}