{"id":"https://openalex.org/W1978714575","doi":"https://doi.org/10.1016/j.ejmech.2014.03.045","title":"6-Amino-2,4,5-trimethylpyridin-3-ols: A new general synthetic route and antiangiogenic activity","display_name":"6-Amino-2,4,5-trimethylpyridin-3-ols: A new general synthetic route and antiangiogenic activity","publication_year":2014,"publication_date":"2014-03-20","ids":{"openalex":"https://openalex.org/W1978714575","doi":"https://doi.org/10.1016/j.ejmech.2014.03.045","mag":"1978714575","pmid":"https://pubmed.ncbi.nlm.nih.gov/24681390"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2014.03.045","doi":"https://doi.org/10.1016/j.ejmech.2014.03.045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2014.03.045","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075617460","display_name":"Dong-Guk Kim","orcid":"https://orcid.org/0000-0002-8600-6571","observed_orcids":["https://orcid.org/0000-0002-8600-6571","https://orcid.org/0009-0005-3872-2388"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dong-Guk Kim","raw_affiliation_strings":["College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044001423","display_name":"Youra Kang","orcid":"https://orcid.org/0000-0002-3504-2361","observed_orcids":["https://orcid.org/0000-0002-3504-2361"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youra Kang","raw_affiliation_strings":["College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336461","display_name":"Hyunji Lee","orcid":"https://orcid.org/0000-0001-8463-5078","observed_orcids":["https://orcid.org/0000-0001-8463-5078","https://orcid.org/0000-0001-9478-8473"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunji Lee","raw_affiliation_strings":["College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100744790","display_name":"Eun Kyung Lee","orcid":"https://orcid.org/0000-0003-0098-0873","observed_orcids":["https://orcid.org/0000-0003-0098-0873"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Kyung Lee","raw_affiliation_strings":["College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071300207","display_name":"Tae\u2010gyu Nam","orcid":"https://orcid.org/0000-0002-5292-9335","observed_orcids":["https://orcid.org/0000-0002-5292-9335"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Tae-gyu Nam","raw_affiliation_strings":["Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 426-791, Republic of Korea. Electronic address: tnam@hanyang.ac.kr","Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 426-791,,Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-5292-9335","affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 426-791, Republic of Korea. Electronic address: tnam@hanyang.ac.kr","institution_ids":["https://openalex.org/I4575257"]},{"raw_affiliation_string":"Department of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan 426-791,,Republic of Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101774713","display_name":"Jung\u2010Ae Kim","orcid":"https://orcid.org/0000-0002-0824-8532","observed_orcids":["https://orcid.org/0000-0002-0824-8532"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung-Ae Kim","raw_affiliation_strings":["College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: jakim@yu.ac.kr","College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: jakim@yu.ac.kr","institution_ids":["https://openalex.org/I55240360"]},{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046649612","display_name":"Byeong\u2010Seon Jeong","orcid":"https://orcid.org/0000-0002-7814-6638","observed_orcids":["https://orcid.org/0000-0002-7814-6638"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byeong-Seon Jeong","raw_affiliation_strings":["College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: jeongb@ynu.ac.kr","College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: jeongb@ynu.ac.kr","institution_ids":["https://openalex.org/I55240360"]},{"raw_affiliation_string":"College of Pharmacy and Institute for Drug Research, Yeungnam University, Gyeongsan 712-749, Republic of Korea","institution_ids":["https://openalex.org/I55240360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046649612","https://openalex.org/A5071300207","https://openalex.org/A5101774713"],"corresponding_institution_ids":["https://openalex.org/I4575257","https://openalex.org/I55240360"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":2.0356,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.85113677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"78","issue":null,"first_page":"126","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.03449999913573265,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyridoxine","display_name":"pyridoxine","score":0.8619999885559082},{"id":"https://openalex.org/keywords/buchwald-hartwig-amination","display_name":"Buchwald-Hartwig amination","score":0.9210000038146973},{"id":"https://openalex.org/keywords/palladium-catalyzed-amination","display_name":"palladium-catalyzed amination","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chick-chorioallantoic-membrane-assay","display_name":"chick chorioallantoic membrane assay","score":0.8960000276565552},{"id":"https://openalex.org/keywords/synthetic-route","display_name":"synthetic route","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9146777391433716},{"id":"https://openalex.org/C198503264","wikidata":"https://www.wikidata.org/wiki/Q471635","display_name":"Amination","level":3,"score":0.778968870639801},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5951771140098572},{"id":"https://openalex.org/C97230052","wikidata":"https://www.wikidata.org/wiki/Q3854334","display_name":"Chorioallantoic membrane","level":3,"score":0.5759490728378296},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5538477301597595},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5476974844932556},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.437935471534729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24558311700820923},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20995932817459106},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07072049379348755}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ejmech.2014.03.045","doi":"https://doi.org/10.1016/j.ejmech.2014.03.045","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2014.03.045","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:24681390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24681390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:repository.hanyang.ac.kr:20.500.11754/92481","doi":null,"is_oa":false,"landing_page_url":"http://repository.hanyang.ac.kr/handle/20.500.11754/92481","pdf_url":null,"source":{"id":"https://openalex.org/S4306401328","display_name":"The Royal Society of Chemistry\u2019s Journals, Books and Databases (The Royal Society of Chemistry)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2751430930","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/I2751430930"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7837298232","display_name":null,"funder_award_id":"2012R1A1A2039174","funder_id":"https://openalex.org/F4320322349","funder_display_name":"Ministry of Education, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1495287184","https://openalex.org/W1567523921","https://openalex.org/W1605392416","https://openalex.org/W1679229092","https://openalex.org/W1969855058","https://openalex.org/W1974932843","https://openalex.org/W1978139448","https://openalex.org/W1981486175","https://openalex.org/W1984233763","https://openalex.org/W1995827857","https://openalex.org/W1997541848","https://openalex.org/W1997862837","https://openalex.org/W2001303849","https://openalex.org/W2010802054","https://openalex.org/W2017594209","https://openalex.org/W2019428265","https://openalex.org/W2026644063","https://openalex.org/W2027258147","https://openalex.org/W2047803864","https://openalex.org/W2060469597","https://openalex.org/W2067102002","https://openalex.org/W2067216473","https://openalex.org/W2070513297","https://openalex.org/W2073208182","https://openalex.org/W2074164427","https://openalex.org/W2077629624","https://openalex.org/W2079071346","https://openalex.org/W2079150475","https://openalex.org/W2081588643","https://openalex.org/W2083790594","https://openalex.org/W2097148620","https://openalex.org/W2120799681","https://openalex.org/W2120895512","https://openalex.org/W2122435011","https://openalex.org/W2122751252","https://openalex.org/W2125316966","https://openalex.org/W2128560067","https://openalex.org/W2129120705","https://openalex.org/W2144026946","https://openalex.org/W2144125050","https://openalex.org/W2163239845","https://openalex.org/W2165352032","https://openalex.org/W2175906584","https://openalex.org/W2326718752","https://openalex.org/W2398288242","https://openalex.org/W2398896513","https://openalex.org/W2793323124","https://openalex.org/W2951305452","https://openalex.org/W2953005666","https://openalex.org/W2953216585","https://openalex.org/W2953222240","https://openalex.org/W3023077022","https://openalex.org/W4249388929"],"related_works":["https://openalex.org/W1998395048","https://openalex.org/W2070011766","https://openalex.org/W2911254565","https://openalex.org/W2061107907","https://openalex.org/W2033285422","https://openalex.org/W2041294909","https://openalex.org/W1976235476","https://openalex.org/W2034606590","https://openalex.org/W2950583542","https://openalex.org/W2949586645"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
