{"id":"https://openalex.org/W1978708057","doi":"https://doi.org/10.1039/c3bm60123d","title":"Molecular weight and architectural dependence of well-defined star-shaped poly(lysine) as a gene delivery vector","display_name":"Molecular weight and architectural dependence of well-defined star-shaped poly(lysine) as a gene delivery vector","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1978708057","doi":"https://doi.org/10.1039/c3bm60123d","mag":"1978708057","pmid":"https://pubmed.ncbi.nlm.nih.gov/32481978"},"language":"en","primary_location":{"id":"doi:10.1039/c3bm60123d","doi":"https://doi.org/10.1039/c3bm60123d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3bm60123d","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mark Byrne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mark Byrne","raw_affiliation_strings":["School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. andreas.heise@dcu.ie","School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. andreas.heise@dcu.ie","institution_ids":["https://openalex.org/I42934936"]},{"raw_affiliation_string":"School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland","institution_ids":["https://openalex.org/I42934936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062975568","display_name":"Danielle Victory","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Danielle Victory","raw_affiliation_strings":["School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016332855","display_name":"Alan Hibbitts","orcid":"https://orcid.org/0000-0002-3763-1397","observed_orcids":["https://orcid.org/0000-0002-3763-1397"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Alan Hibbitts","raw_affiliation_strings":["School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080586917","display_name":"Martin Lanigan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Martin Lanigan","raw_affiliation_strings":["School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025566551","display_name":"Andreas Heise","orcid":"https://orcid.org/0000-0001-5916-8500","observed_orcids":["https://orcid.org/0000-0001-5916-8500"]},"institutions":[{"id":"https://openalex.org/I42934936","display_name":"Dublin City University","ror":"https://ror.org/04a1a1e81","country_code":"IE","type":"education","lineage":["https://openalex.org/I42934936"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Andreas Heise","raw_affiliation_strings":["School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland","institution_ids":["https://openalex.org/I42934936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064641182","display_name":"Sally\u2010Ann Cryan","orcid":"https://orcid.org/0000-0002-3941-496X","observed_orcids":["https://orcid.org/0000-0002-3941-496X"]},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Sally-Ann Cryan","raw_affiliation_strings":["School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland","Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland","institution_ids":["https://openalex.org/I142762351"]},{"raw_affiliation_string":"Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025566551","https://openalex.org/A5064641182"],"corresponding_institution_ids":["https://openalex.org/I142762351","https://openalex.org/I205274468","https://openalex.org/I42934936"],"apc_list":null,"apc_paid":null,"fwci":4.0297,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.94790929,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"12","first_page":"1223","last_page":"1223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.12269999831914902,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.8389999866485596},{"id":"https://openalex.org/keywords/polyplexes","display_name":"polyplexes","score":0.7350000143051147},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pdna-delivery","display_name":"pDNA delivery","score":0.8059999942779541},{"id":"https://openalex.org/keywords/ring-opening-polymerization","display_name":"ring-opening polymerization","score":0.8209999799728394},{"id":"https://openalex.org/keywords/n-carboxyanhydride","display_name":"N-carboxyanhydride","score":0.8759999871253967},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.44200000166893005},{"id":"https://openalex.org/keywords/dendrimer-generation","display_name":"dendrimer generation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2780075363","wikidata":"https://www.wikidata.org/wiki/Q650157","display_name":"Polylysine","level":2,"score":0.7644979953765869},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.651934802532196},{"id":"https://openalex.org/C55637122","wikidata":"https://www.wikidata.org/wiki/Q903923","display_name":"Dendrimer","level":2,"score":0.5533921718597412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5469340682029724},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5388486385345459},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.523521900177002},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.46521854400634766},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.45501840114593506},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.4100162386894226},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.36640286445617676},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2907782793045044},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25972074270248413},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.17605745792388916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17455589771270752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1449306607246399},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09142336249351501},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1039/c3bm60123d","doi":"https://doi.org/10.1039/c3bm60123d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3bm60123d","pdf_url":null,"source":{"id":"https://openalex.org/S2494179437","display_name":"Biomaterials Science","issn_l":"2047-4830","issn":["2047-4830","2047-4849"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Science","raw_type":"journal-article"},{"id":"pmid:32481978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32481978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W182506760","https://openalex.org/W1483766007","https://openalex.org/W1576238436","https://openalex.org/W1969457012","https://openalex.org/W1977633066","https://openalex.org/W1978504648","https://openalex.org/W1979463458","https://openalex.org/W1982464351","https://openalex.org/W1987811891","https://openalex.org/W1989489362","https://openalex.org/W1990845410","https://openalex.org/W1991832475","https://openalex.org/W1992029155","https://openalex.org/W1995323554","https://openalex.org/W1995953743","https://openalex.org/W2000136129","https://openalex.org/W2001710494","https://openalex.org/W2003414091","https://openalex.org/W2006990153","https://openalex.org/W2007115871","https://openalex.org/W2008802238","https://openalex.org/W2012879650","https://openalex.org/W2014070367","https://openalex.org/W2015325415","https://openalex.org/W2020767725","https://openalex.org/W2021140900","https://openalex.org/W2022897389","https://openalex.org/W2025381822","https://openalex.org/W2026442759","https://openalex.org/W2027116970","https://openalex.org/W2027401476","https://openalex.org/W2031756847","https://openalex.org/W2043764483","https://openalex.org/W2044927881","https://openalex.org/W2047167179","https://openalex.org/W2050221254","https://openalex.org/W2051738239","https://openalex.org/W2054809494","https://openalex.org/W2055225696","https://openalex.org/W2058029221","https://openalex.org/W2060257168","https://openalex.org/W2061223273","https://openalex.org/W2062114717","https://openalex.org/W2062874590","https://openalex.org/W2069845593","https://openalex.org/W2074577006","https://openalex.org/W2074606471","https://openalex.org/W2077101279","https://openalex.org/W2080304455","https://openalex.org/W2080553254","https://openalex.org/W2080823739","https://openalex.org/W2092097760","https://openalex.org/W2093241258","https://openalex.org/W2093881907","https://openalex.org/W2094367222","https://openalex.org/W2102739188","https://openalex.org/W2106670806","https://openalex.org/W2119235918","https://openalex.org/W2121930694","https://openalex.org/W2123238521","https://openalex.org/W2138159091","https://openalex.org/W2140712333","https://openalex.org/W2146693413","https://openalex.org/W2166956902","https://openalex.org/W2169367057","https://openalex.org/W2334745441"],"related_works":["https://openalex.org/W2057776907","https://openalex.org/W4377084776","https://openalex.org/W1994678502","https://openalex.org/W2068265599","https://openalex.org/W2009939013","https://openalex.org/W2021071879","https://openalex.org/W1970755977","https://openalex.org/W2291560980","https://openalex.org/W2152145927","https://openalex.org/W2062114717"],"abstract_inverted_index":{"A":[0],"series":[1,47],"of":[2,15,19,25,27,48,65,131,135,172,266,274,307,315],"well-defined":[3],"star-shaped":[4,63,116,127,223,252],"polypeptides":[5,128],"were":[6,42,78,99,113,129],"successfully":[7],"synthesised":[8],"by":[9,149,207,282],"the":[10,16,199,244,267,276,283,290,297,313],"ring":[11],"opening":[12],"polymerisation":[13],"(ROP)":[14],"N-carboxyanhydride":[17],"(NCA)":[18],"\u03b5-carbobenzyloxy-L-lysine":[20],"(ZLL)":[21],"using":[22],"a":[23,46],"range":[24],"generations":[26],"polypropylene":[28],"imine":[29],"(PPI)":[30],"dendrimers":[31],"as":[32,147,162,205,287,289,319],"multifunctional":[33],"initiators.":[34],"The":[35,126],"monomer":[36],"feed":[37],"ratio":[38],"and":[39,56,72,83,98,110,119,152,203,304],"dendrimer":[40,50,317],"generation":[41],"varied":[43],"to":[44,80,85,88,92,144,166,257,271],"afford":[45],"polypeptide":[49,69,316],"hybrids":[51,318],"with":[52,101],"superior":[53],"structural":[54],"versatility":[55],"functionality.":[57],"Subsequent":[58],"protecting":[59,275],"group":[60],"removal":[61],"yielded":[62],"poly(lysine)":[64,185],"controlled":[66],"variation":[67],"in":[68,108,159,181,236,247,262],"chain":[70],"length":[71],"arm":[73],"multiplicity.":[74],"Star-shaped":[75],"PLL":[76,103,117,121,146,164,228,253,259],"polymers":[77,269],"used":[79],"prepare":[81],"pDNA":[82],"siRNA":[84,160,169,187],"form":[86],"\u201cpolyplexes\u201d":[87],"determine":[89],"their":[90],"ability":[91],"complex":[93,168],"different":[94,309],"nucleic":[95,137,277,299],"acid":[96,278,300],"cargoes":[97,279],"compared":[100,143,256],"linear":[102,120,145,163,227,258],"polyplex":[104],"controls.":[105],"Significant":[106],"differences":[107],"size":[109,174],"surface":[111],"charge":[112],"seen":[114,250],"between":[115],"polyplexes":[118,122,161,188,220,225,254,261],"for":[123,175,221,251],"both":[124,136],"cargoes.":[125],"capable":[130,273],"more":[132],"effective":[133],"complexation":[134],"acids":[138],"at":[139,191],"low":[140],"N/P":[141,193],"ratios":[142],"evidenced":[148],"zeta":[150],"potential":[151,314],"electrophoretic":[153],"data.":[154],"This":[155,234],"was":[156],"particularly":[157],"evident":[158],"failed":[165],"completely":[167],"into":[170],"nanocomplexes":[171],"appropriate":[173],"cell":[176],"transfection":[177],"i.e.":[178],"<200":[179],"nm":[180,190],"size,":[182],"while":[183,226],"star":[184],"formed":[186,229],"<100":[189],"certain":[192],"ratios,":[194],"albeit":[195],"strongly":[196],"dependent":[197],"on":[198],"particular":[200],"molecular":[201],"weight":[202],"architecture,":[204],"analysed":[206],"dynamic":[208],"light":[209],"scattering":[210],"(DLS).":[211],"Atomic":[212],"force":[213],"microscopy":[214],"(AFM)":[215],"identified":[216],"discrete":[217],"spherically":[218],"shaped":[219,232],"all":[222],"polypeptide-based":[224],"elongated":[230],"irregular":[231],"complexes.":[233],"difference":[235],"morphology":[237,303],"may":[238],"go":[239],"some":[240],"way":[241],"towards":[242],"explaining":[243],"300-fold":[245],"increase":[246],"luciferase":[248],"expression":[249],"G5(64)-PLL40":[255],"pGLuc":[260],"epithelial":[263],"cells.":[264],"Each":[265],"PPI-PLL":[268],"appeared":[270],"be":[272],"from":[280],"degradation":[281],"relevant":[284],"nuclease":[285],"enzyme":[286],"effectively":[288],"positive":[291],"control":[292],"polyethyleneimine":[293],"(PEI)":[294],"polyplexes.":[295],"Overall":[296],"promising":[298],"complexation,":[301],"sizing,":[302],"protection":[305],"capacity":[306],"two":[308],"genetic":[310],"\u201ccargoes\u201d":[311],"highlight":[312],"gene":[320],"delivery":[321],"vectors.":[322]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
