{"id":"https://openalex.org/W1978703603","doi":"https://doi.org/10.1007/s10930-015-9603-4","title":"A Single Amino Acid in the Hinge Loop Region of the FOXP Forkhead Domain is Significant for Dimerisation","display_name":"A Single Amino Acid in the Hinge Loop Region of the FOXP Forkhead Domain is Significant for Dimerisation","publication_year":2015,"publication_date":"2015-02-27","ids":{"openalex":"https://openalex.org/W1978703603","doi":"https://doi.org/10.1007/s10930-015-9603-4","mag":"1978703603","pmid":"https://pubmed.ncbi.nlm.nih.gov/25724387"},"language":"en","primary_location":{"id":"doi:10.1007/s10930-015-9603-4","doi":"https://doi.org/10.1007/s10930-015-9603-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10930-015-9603-4","pdf_url":null,"source":{"id":"https://openalex.org/S201049572","display_name":"The Protein Journal","issn_l":"1572-3887","issn":["1572-3887","1875-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Protein Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043682503","display_name":"Kershia Perumal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Kershia Perumal","raw_affiliation_strings":["Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Ave, Johannesburg, 2050, South Africa","university of the Witwatersrand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Ave, Johannesburg, 2050, South Africa","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"university of the Witwatersrand","institution_ids":["https://openalex.org/I192619145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041509012","display_name":"Heini W. Dirr","orcid":"https://orcid.org/0000-0003-1455-7769","observed_orcids":["https://orcid.org/0000-0003-1455-7769"]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Heini W. Dirr","raw_affiliation_strings":["Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Ave, Johannesburg, 2050, South Africa","university of the Witwatersrand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Ave, Johannesburg, 2050, South Africa","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"university of the Witwatersrand","institution_ids":["https://openalex.org/I192619145"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015603070","display_name":"Sylvia Fanucchi","orcid":"https://orcid.org/0000-0002-2537-1065","observed_orcids":["https://orcid.org/0000-0002-2537-1065"]},"institutions":[{"id":"https://openalex.org/I192619145","display_name":"University of the Witwatersrand","ror":"https://ror.org/03rp50x72","country_code":"ZA","type":"education","lineage":["https://openalex.org/I192619145"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Sylvia Fanucchi","raw_affiliation_strings":["Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Ave, Johannesburg, 2050, South Africa","university of the Witwatersrand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, 1 Jan Smuts Ave, Johannesburg, 2050, South Africa","institution_ids":["https://openalex.org/I192619145"]},{"raw_affiliation_string":"university of the Witwatersrand","institution_ids":["https://openalex.org/I192619145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015603070"],"corresponding_institution_ids":["https://openalex.org/I192619145"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.6922,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.65635231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"34","issue":"2","first_page":"111","last_page":"121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp","display_name":"FoxP","score":0.7170000076293945},{"id":"https://openalex.org/keywords/forkhead-domain","display_name":"forkhead domain","score":0.9629999995231628},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7379999756813049},{"id":"https://openalex.org/keywords/domain-swapping","display_name":"domain swapping","score":0.7889999747276306},{"id":"https://openalex.org/keywords/foxp2","display_name":"FOXP2","score":0.7950000166893005},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9729999899864197},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.5929999947547913},{"id":"https://openalex.org/keywords/dna-binding-affinity","display_name":"DNA binding affinity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/winged-helix-transcription-factor","display_name":"winged helix transcription factor","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C207259873","wikidata":"https://www.wikidata.org/wiki/Q227241","display_name":"FOXP2","level":4,"score":0.6916232705116272},{"id":"https://openalex.org/C50929876","wikidata":"https://www.wikidata.org/wiki/Q164280","display_name":"Subfamily","level":3,"score":0.6261177062988281},{"id":"https://openalex.org/C2908554999","wikidata":"https://www.wikidata.org/wiki/Q905506","display_name":"Forkhead Transcription Factors","level":4,"score":0.5372706651687622},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.4794572591781616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45992952585220337},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.430009663105011},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41940316557884216},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41446298360824585},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35036951303482056},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3113027513027191},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24565929174423218},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10930-015-9603-4","doi":"https://doi.org/10.1007/s10930-015-9603-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10930-015-9603-4","pdf_url":null,"source":{"id":"https://openalex.org/S201049572","display_name":"The Protein Journal","issn_l":"1572-3887","issn":["1572-3887","1875-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Protein Journal","raw_type":"journal-article"},{"id":"pmid:25724387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25724387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The protein journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1486722793","https://openalex.org/W1587687959","https://openalex.org/W1590313270","https://openalex.org/W1591864042","https://openalex.org/W1860073488","https://openalex.org/W1970232844","https://openalex.org/W1975666063","https://openalex.org/W1977020297","https://openalex.org/W1978385061","https://openalex.org/W1978664503","https://openalex.org/W1982626641","https://openalex.org/W1982995354","https://openalex.org/W1983307326","https://openalex.org/W1986520134","https://openalex.org/W1990258459","https://openalex.org/W1998674552","https://openalex.org/W1998924554","https://openalex.org/W2005144583","https://openalex.org/W2005914057","https://openalex.org/W2009801111","https://openalex.org/W2017798666","https://openalex.org/W2026727321","https://openalex.org/W2028390551","https://openalex.org/W2029802808","https://openalex.org/W2031196637","https://openalex.org/W2046886869","https://openalex.org/W2060116181","https://openalex.org/W2061107874","https://openalex.org/W2066795633","https://openalex.org/W2069546738","https://openalex.org/W2070403076","https://openalex.org/W2070496280","https://openalex.org/W2077405765","https://openalex.org/W2078027525","https://openalex.org/W2081797865","https://openalex.org/W2082396953","https://openalex.org/W2084032108","https://openalex.org/W2089231778","https://openalex.org/W2096028394","https://openalex.org/W2098592067","https://openalex.org/W2110900781","https://openalex.org/W2113020073","https://openalex.org/W2116673593","https://openalex.org/W2119667044","https://openalex.org/W2125230704","https://openalex.org/W2130695746","https://openalex.org/W2131915909","https://openalex.org/W2133023372","https://openalex.org/W2134399305","https://openalex.org/W2136518914","https://openalex.org/W2137015675","https://openalex.org/W2137902859","https://openalex.org/W2146098930","https://openalex.org/W2151363218","https://openalex.org/W2160082320","https://openalex.org/W2163431499","https://openalex.org/W2166725781"],"related_works":["https://openalex.org/W2151363218","https://openalex.org/W2806362156","https://openalex.org/W2134399305","https://openalex.org/W2410194959","https://openalex.org/W2299992559","https://openalex.org/W2475881208","https://openalex.org/W3130854956","https://openalex.org/W4376616737","https://openalex.org/W4319931887","https://openalex.org/W4377011691"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
