{"id":"https://openalex.org/W1978699642","doi":"https://doi.org/10.1016/s1286-4579(00)01275-2","title":"Using genetics to probe host-virus interactions; the mouse mammary tumor virus model","display_name":"Using genetics to probe host-virus interactions; the mouse mammary tumor virus model","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W1978699642","doi":"https://doi.org/10.1016/s1286-4579(00)01275-2","mag":"1978699642","pmid":"https://pubmed.ncbi.nlm.nih.gov/11008111"},"language":"en","primary_location":{"id":"doi:10.1016/s1286-4579(00)01275-2","doi":"https://doi.org/10.1016/s1286-4579(00)01275-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1286-4579(00)01275-2","pdf_url":null,"source":{"id":"https://openalex.org/S56361996","display_name":"Microbes and Infection","issn_l":"1286-4579","issn":["1286-4579","1769-714X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and Infection","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s1286-4579(00)01275-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078563618","display_name":"Susan R. Ross","orcid":"https://orcid.org/0000-0002-3094-3769","observed_orcids":["https://orcid.org/0000-0002-3094-3769"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan R Ross","raw_affiliation_strings":["Department of Microbiology, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104-6142, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Pennsylvania, 421 Curie Blvd., Philadelphia, PA 19104-6142, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078563618"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":{"value":3510,"currency":"USD","value_usd":3510},"fwci":0.2613,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.29445727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"2","issue":"10","first_page":"1215","last_page":"1223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.16850000619888306,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.906000018119812},{"id":"https://openalex.org/keywords/mouse-mammary-tumor-virus","display_name":"mouse mammary tumor virus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/retroviruses","display_name":"retroviruses","score":0.8149999976158142},{"id":"https://openalex.org/keywords/genetic-susceptibility-to-infection","display_name":"genetic susceptibility to infection","score":0.7490000128746033},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.8209999799728394},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.7889999747276306},{"id":"https://openalex.org/keywords/host-antiviral-response","display_name":"host antiviral response","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/resistance-genes","display_name":"resistance genes","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.913693904876709},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7155858874320984},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.6327450275421143},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6190481185913086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5518062710762024},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5435535311698914},{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.458842396736145},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4507829248905182},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.43476149439811707},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.4210323989391327},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.25353580713272095}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008324","descriptor_name":"Mammary Tumor Virus, Mouse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008324","descriptor_name":"Mammary Tumor Virus, Mouse","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012192","descriptor_name":"Retroviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012192","descriptor_name":"Retroviridae Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012192","descriptor_name":"Retroviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1286-4579(00)01275-2","doi":"https://doi.org/10.1016/s1286-4579(00)01275-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1286-4579(00)01275-2","pdf_url":null,"source":{"id":"https://openalex.org/S56361996","display_name":"Microbes and Infection","issn_l":"1286-4579","issn":["1286-4579","1769-714X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and Infection","raw_type":"journal-article"},{"id":"pmid:11008111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11008111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and infection","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s1286-4579(00)01275-2","doi":"https://doi.org/10.1016/s1286-4579(00)01275-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1286-4579(00)01275-2","pdf_url":null,"source":{"id":"https://openalex.org/S56361996","display_name":"Microbes and Infection","issn_l":"1286-4579","issn":["1286-4579","1769-714X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbes and Infection","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1496519404","https://openalex.org/W1523608178","https://openalex.org/W1534615713","https://openalex.org/W1540704453","https://openalex.org/W1548941542","https://openalex.org/W1566980635","https://openalex.org/W1575664869","https://openalex.org/W1592359554","https://openalex.org/W1608648424","https://openalex.org/W1654620809","https://openalex.org/W1904730579","https://openalex.org/W1909617247","https://openalex.org/W1957956426","https://openalex.org/W1966870588","https://openalex.org/W1969405734","https://openalex.org/W1985130808","https://openalex.org/W1988104934","https://openalex.org/W1994529600","https://openalex.org/W1995270566","https://openalex.org/W2000249160","https://openalex.org/W2005991339","https://openalex.org/W2007587081","https://openalex.org/W2013861095","https://openalex.org/W2014958998","https://openalex.org/W2020460888","https://openalex.org/W2025900655","https://openalex.org/W2042626190","https://openalex.org/W2044110769","https://openalex.org/W2044159010","https://openalex.org/W2045764827","https://openalex.org/W2047977785","https://openalex.org/W2048209599","https://openalex.org/W2055891323","https://openalex.org/W2070594128","https://openalex.org/W2073734149","https://openalex.org/W2078024584","https://openalex.org/W2078301711","https://openalex.org/W2080350299","https://openalex.org/W2086417745","https://openalex.org/W2090630729","https://openalex.org/W2096592974","https://openalex.org/W2098512609","https://openalex.org/W2106922110","https://openalex.org/W2110827592","https://openalex.org/W2111023224","https://openalex.org/W2111563223","https://openalex.org/W2115985807","https://openalex.org/W2119708398","https://openalex.org/W2120338530","https://openalex.org/W2125841548","https://openalex.org/W2126067433","https://openalex.org/W2126503033","https://openalex.org/W2129319296","https://openalex.org/W2138197522","https://openalex.org/W2138586842","https://openalex.org/W2142440161","https://openalex.org/W2146148599","https://openalex.org/W2169270915","https://openalex.org/W2171023095","https://openalex.org/W2259167482","https://openalex.org/W2996114515","https://openalex.org/W4232797909","https://openalex.org/W4313305982","https://openalex.org/W6680408102"],"related_works":["https://openalex.org/W1534615713","https://openalex.org/W2062059238","https://openalex.org/W2977807326","https://openalex.org/W1998372920","https://openalex.org/W1571418177","https://openalex.org/W2110615045","https://openalex.org/W1996275669","https://openalex.org/W2134759387","https://openalex.org/W2886513277","https://openalex.org/W110051956"],"abstract_inverted_index":{"It":[0],"is":[1,5,76],"clear":[2],"that":[3],"there":[4],"genetic":[6],"variation":[7],"among":[8],"different":[9],"individuals":[10],"in":[11,26],"their":[12],"susceptibility":[13,30],"to":[14,31,37,46,68,91,114],"infection":[15,33,42,106],"by":[16],"viruses":[17],"and":[18,43,45,65,108],"other":[19],"pathogens.":[20],"Identification":[21],"of":[22,41,55,59,89,102,111],"the":[23,56,66,87,93,100,104,109,112],"genes":[24],"involved":[25],"conferring":[27],"resistance":[28],"or":[29,51],"viral":[32,105],"will":[34],"allow":[35],"us":[36],"understand":[38],"both":[39,103],"mechanisms":[40],"pathogenesis":[44],"develop":[47],"reagents":[48],"for":[49,79],"treating":[50],"preventing":[52],"them.":[53],"Because":[54],"large":[57],"number":[58],"genetically":[60],"well-characterized":[61],"inbred":[62],"mouse":[63,95],"strains":[64],"ability":[67],"generate":[69],"targeted":[70],"germ":[71],"line":[72],"mutations,":[73],"this":[74,115],"species":[75],"particularly":[77],"well-suited":[78],"such":[80],"analysis.":[81],"This":[82],"review":[83],"focuses":[84],"on":[85],"how":[86],"use":[88],"genetics":[90],"study":[92],"retrovirus":[94],"mammary":[96],"tumor":[97],"virus":[98],"allowed":[99],"dissection":[101],"pathway":[107],"response":[110],"host":[113],"infection.":[116]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}