{"id":"https://openalex.org/W1978697462","doi":"https://doi.org/10.1111/j.1349-7006.1997.tb00320.x","title":"Antitumor Activity of a Novel Quinoline Derivative, TAS\u2010103, with Inhibitory Effects on Topoisomerases I and II","display_name":"Antitumor Activity of a Novel Quinoline Derivative, TAS\u2010103, with Inhibitory Effects on Topoisomerases I and II","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W1978697462","doi":"https://doi.org/10.1111/j.1349-7006.1997.tb00320.x","mag":"1978697462","pmid":"https://pubmed.ncbi.nlm.nih.gov/9414662","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5921285"},"language":"en","primary_location":{"id":"doi:10.1111/j.1349-7006.1997.tb00320.x","doi":"https://doi.org/10.1111/j.1349-7006.1997.tb00320.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1997.tb00320.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5921285","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077000893","display_name":"Teruhiro Utsugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruhiro Utsugi","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, Saitama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, Saitama","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053433413","display_name":"Kumio Aoyagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumio Aoyagi","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109869140","display_name":"Tetsuji Asao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuji Asao","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012896911","display_name":"Shinji Okazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinji Okazaki","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067486875","display_name":"Yoshimi Aoyagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimi Aoyagi","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masaki Sano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Sano","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111501602","display_name":"Konstanty Wierzba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Konstanty Wierzba","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066192865","display_name":"Yuji Yamada","orcid":"https://orcid.org/0000-0003-2338-6906","observed_orcids":["https://orcid.org/0000-0003-2338-6906"]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Yamada","raw_affiliation_strings":["Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taiho Pharmaceutical Co. Ltd., Hanno Research Center, 1\u201327 Misugidai, Hanno, Saitama 357","institution_ids":["https://openalex.org/I4210120269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210120269"],"apc_list":null,"apc_paid":null,"fwci":1.3037,"has_fulltext":false,"cited_by_count":118,"citation_normalized_percentile":{"value":0.79067327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"88","issue":"10","first_page":"992","last_page":"1002"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quinoline-derivatives","display_name":"quinoline derivatives","score":0.7850000262260437},{"id":"https://openalex.org/keywords/topoisomerase-i","display_name":"topoisomerase I","score":0.8930000066757202},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":1.0},{"id":"https://openalex.org/keywords/topoisomerase-inhibitors","display_name":"topoisomerase inhibitors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dna-cleavage-complex","display_name":"DNA cleavage complex","score":0.6060000061988831},{"id":"https://openalex.org/keywords/p388-leukemia-cells","display_name":"P388 leukemia cells","score":0.7509999871253967},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.781000018119812},{"id":"https://openalex.org/keywords/human-tumor-xenografts","display_name":"human tumor xenografts","score":0.8880000114440918},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9620000123977661},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.8539865016937256},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.7782896757125854},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.7222487330436707},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.6436793804168701},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.630471408367157},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49748972058296204},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.49265390634536743},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.46739205718040466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43271970748901367},{"id":"https://openalex.org/C2778616834","wikidata":"https://www.wikidata.org/wiki/Q281044","display_name":"Topoisomerase inhibitor","level":4,"score":0.4207804203033447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4042862355709076},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35605716705322266},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3499763011932373},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33847954869270325},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.277742475271225},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22214314341545105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21104580163955688},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10757437348365784},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002166","descriptor_name":"Camptothecin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007192","descriptor_name":"Indenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007192","descriptor_name":"Indenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007192","descriptor_name":"Indenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059004","descriptor_name":"Topoisomerase I Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059005","descriptor_name":"Topoisomerase II Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1349-7006.1997.tb00320.x","doi":"https://doi.org/10.1111/j.1349-7006.1997.tb00320.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1349-7006.1997.tb00320.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210193983","display_name":"Japanese Journal of Cancer Research","issn_l":"0910-5050","issn":["0910-5050","1344-6428","1876-4673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4864231","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5921285","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5921285","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5921285","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jpn J Cancer Res","raw_type":"Text"},{"id":"pmid:9414662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9414662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of cancer research : Gann","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4864231","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5921285","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1499578540","https://openalex.org/W1545715398","https://openalex.org/W1567663060","https://openalex.org/W1584024009","https://openalex.org/W1585984676","https://openalex.org/W1592664042","https://openalex.org/W1632388334","https://openalex.org/W1766532836","https://openalex.org/W1816032677","https://openalex.org/W1820632660","https://openalex.org/W1897082568","https://openalex.org/W1923310201","https://openalex.org/W1946967684","https://openalex.org/W1977779461","https://openalex.org/W1979230039","https://openalex.org/W1985376829","https://openalex.org/W1994240050","https://openalex.org/W2006437952","https://openalex.org/W2010511880","https://openalex.org/W2016254453","https://openalex.org/W2029759544","https://openalex.org/W2042367294","https://openalex.org/W2057409012","https://openalex.org/W2060846964","https://openalex.org/W2068391687","https://openalex.org/W2075733574","https://openalex.org/W2088047613","https://openalex.org/W2095696085","https://openalex.org/W2102345056","https://openalex.org/W2115012618","https://openalex.org/W2120148445","https://openalex.org/W2128297167","https://openalex.org/W2142929114","https://openalex.org/W2148172992","https://openalex.org/W2149318965","https://openalex.org/W2150403997","https://openalex.org/W2328369261","https://openalex.org/W2404444211","https://openalex.org/W2408034198","https://openalex.org/W4236530034"],"related_works":["https://openalex.org/W1969592907","https://openalex.org/W2411868673","https://openalex.org/W2027572061","https://openalex.org/W2083282724","https://openalex.org/W1996527072","https://openalex.org/W1969842994","https://openalex.org/W2945684863","https://openalex.org/W4220959939","https://openalex.org/W2063989721","https://openalex.org/W2805555742"],"abstract_inverted_index":{"A":[0],"novel":[1],"quinoline":[2],"derivative,":[3],"TAS-103":[4,26,65,120,150],"(6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin":[5],"-7-one":[6],"dihydrochloride),":[7],"was":[8,112,151],"developed":[9],"as":[10],"an":[11],"anticancer":[12],"agent":[13],"targeting":[14],"topoisomerases":[15],"(topo)":[16],"I":[17,29,68],"and":[18,30,49,57,69,129,144],"II,":[19],"with":[20],"marked":[21,122],"efficacy":[22,123,148],"in":[23,73,106,134],"solid":[24],"tumors.":[25,118],"inhibited":[27],"topo":[28,67,81,95],"II":[31],"(IC50:":[32,60],"2":[33],"microM,":[34,62],"6.5":[35],"microM)":[36],"at":[37],"a":[38,51,77,91,130],"concentration":[39],"similar":[40,78],"to":[41,84],"or":[42,160],"lower":[43],"than":[44,98,154],"those":[45],"of":[46,80,94,149,156],"previous":[47],"agents,":[48],"had":[50,121],"strong":[52],"cytotoxic":[53],"effect":[54],"on":[55],"P388":[56],"KB":[58,74],"cells":[59],"0.0011":[61],"0.0096":[63],"microM).":[64],"stabilized":[66],"II-DNA":[70,82],"cleavable":[71],"complexes":[72],"cells,":[75],"generating":[76],"amount":[79,93],"complex":[83,97],"that":[85,99,155],"induced":[86],"by":[87,101],"etoposide":[88],"(VP-16)":[89],"but":[90],"smaller":[92],"I-DNA":[96],"produced":[100],"camptothecin":[102],"(CPT).":[103],"In":[104],"the":[105],"vivo":[107],"study,":[108],"intermittent":[109],"i.v.":[110],"administration":[111],"markedly":[113],"effective":[114],"against":[115,124],"s.c.-implanted":[116],"murine":[117],"Furthermore,":[119],"various":[125],"lung":[126],"metastatic":[127],"tumors,":[128],"broad":[131],"antitumor":[132],"spectrum":[133],"human":[135],"tumor":[136],"xenografts":[137],"(derived":[138],"from":[139],"lung,":[140],"colon,":[141],"stomach,":[142],"breast,":[143],"pancreatic":[145],"cancer).":[146],"The":[147],"generally":[152],"greater":[153],"irinotecan":[157],"(CPT-11),":[158],"VP-16,":[159],"cis-diamminedichloroplatinum":[161],"(CDDP).":[162]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}