{"id":"https://openalex.org/W1978687013","doi":"https://doi.org/10.1371/journal.pone.0025168","title":"TGF-\u03b2 Regulates DNA Methyltransferase Expression in Prostate Cancer, Correlates with Aggressive Capabilities, and Predicts Disease Recurrence","display_name":"TGF-\u03b2 Regulates DNA Methyltransferase Expression in Prostate Cancer, Correlates with Aggressive Capabilities, and Predicts Disease Recurrence","publication_year":2011,"publication_date":"2011-09-30","ids":{"openalex":"https://openalex.org/W1978687013","doi":"https://doi.org/10.1371/journal.pone.0025168","mag":"1978687013","pmid":"https://pubmed.ncbi.nlm.nih.gov/21980391","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3184137"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0025168","doi":"https://doi.org/10.1371/journal.pone.0025168","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0025168","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0025168&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0025168&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100381945","display_name":"Qiang Zhang","orcid":"https://orcid.org/0000-0002-8359-3715","observed_orcids":["https://orcid.org/0000-0002-8359-3715"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qiang Zhang","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America. q-zhang2@northwestern.edu","Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America. q-zhang2@northwestern.edu","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Chen","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107093696","display_name":"Brian T. Helfand","orcid":"https://orcid.org/0000-0002-7707-3318","observed_orcids":["https://orcid.org/0000-0002-7707-3318"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian T. Helfand","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044026355","display_name":"Thomas L. Jang","orcid":"https://orcid.org/0000-0001-5886-3835","observed_orcids":["https://orcid.org/0000-0001-5886-3835"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas L. Jang","raw_affiliation_strings":["The Cancer Institute of New Jersey, Robert Wood Johnson Medical School/University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Cancer Institute of New Jersey, Robert Wood Johnson Medical School/University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, United States of America","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006595036","display_name":"Vidit Sharma","orcid":"https://orcid.org/0000-0002-4715-5451","observed_orcids":["https://orcid.org/0000-0002-4715-5451"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidit Sharma","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109079740","display_name":"James M. Kozlowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Kozlowski","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003177689","display_name":"Timothy Michael Kuzel","orcid":"https://orcid.org/0000-0002-7523-2397","observed_orcids":["https://orcid.org/0000-0002-7523-2397"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Michael Kuzel","raw_affiliation_strings":["Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070760688","display_name":"Lihua Julie Zhu","orcid":"https://orcid.org/0000-0001-7416-0590","observed_orcids":["https://orcid.org/0000-0001-7416-0590"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihua J. Zhu","raw_affiliation_strings":["Program in Gene Function and Expression, University of Massachusetts Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Gene Function and Expression, University of Massachusetts Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080276829","display_name":"Ximing J. Yang","orcid":"https://orcid.org/0000-0002-3370-6208","observed_orcids":["https://orcid.org/0000-0002-3370-6208"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ximing J. Yang","raw_affiliation_strings":["Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069845633","display_name":"Borko Javonovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Borko Javonovic","raw_affiliation_strings":["Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664566","display_name":"Yinglu Guo","orcid":"https://orcid.org/0000-0001-5744-7119","observed_orcids":["https://orcid.org/0000-0001-5744-7119"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210130930","display_name":"Peking University First Hospital","ror":"https://ror.org/02z1vqm45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210130930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinglu Guo","raw_affiliation_strings":["Institute of Urology, Department of Urology, The First Hospital, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Urology, Department of Urology, The First Hospital, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210130930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081539344","display_name":"Scott M. Lonning","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Lonning","raw_affiliation_strings":["The Genzyme Corporation, Framingham, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genzyme Corporation, Framingham, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103843714","display_name":"Jay W. Harper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay Harper","raw_affiliation_strings":["The Genzyme Corporation, Framingham, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genzyme Corporation, Framingham, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040137655","display_name":"Beverly A. Teicher","orcid":"https://orcid.org/0000-0003-1535-7304","observed_orcids":["https://orcid.org/0000-0003-1535-7304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beverly A. Teicher","raw_affiliation_strings":["The Genzyme Corporation, Framingham, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Genzyme Corporation, Framingham, Massachusetts, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108201651","display_name":"Charles B. Brendler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"Endeavor Health","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Brendler","raw_affiliation_strings":["Department of Surgery, Northshore University Heathsystem, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Northshore University Heathsystem, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I1339509835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040785654","display_name":"Nengwang Yu","orcid":"https://orcid.org/0000-0002-3488-2270","observed_orcids":["https://orcid.org/0000-0002-3488-2270","https://orcid.org/0000-0002-9131-8166"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nengwang Yu","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065869555","display_name":"William J. Cat\u00e0lona","orcid":"https://orcid.org/0009-0004-2926-5114","observed_orcids":["https://orcid.org/0009-0004-2926-5114"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Catalona","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030411648","display_name":"Chung Lee","orcid":"https://orcid.org/0000-0003-0855-4553","observed_orcids":["https://orcid.org/0000-0003-0855-4553"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung Lee","raw_affiliation_strings":["Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5100381945"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.1132,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.92397774,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"6","issue":"9","first_page":"e25168","last_page":"e25168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7440000176429749},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.824999988079071},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.7540397644042969},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6457017660140991},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.6366642117500305},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6290332078933716},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6165891289710999},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5445320010185242},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4956148862838745},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.48080673813819885},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.47966268658638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4648173451423645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36159589886665344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3339678645133972},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3078199028968811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2569858431816101},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21613511443138123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06013971567153931},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05439966917037964}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011468","descriptor_name":"Prostatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0025168","doi":"https://doi.org/10.1371/journal.pone.0025168","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0025168","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0025168&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2192531","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3184137","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3184137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3184137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21980391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21980391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:14a8162f94b04b4cb87f816db631a2f1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/14a8162f94b04b4cb87f816db631a2f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 9, p e25168 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/132856","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/TGF_Regulates_DNA_Methyltransferase_Expression_in_Prostate_Cancer_Correlates_with_Aggressive_Capabilities_and_Predicts_Disease_Recurrence/132856","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0025168","doi":"https://doi.org/10.1371/journal.pone.0025168","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0025168","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0025168&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G119423602","display_name":null,"funder_award_id":"W81XWH-09-1-0311","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2524343597","display_name":null,"funder_award_id":"P50CA090386","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G3358877230","display_name":null,"funder_award_id":"W81XWH-09-1-0311","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5037168871","display_name":"SPORE in Prostate Cancer","funder_award_id":"P50CA090386","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7692243934","display_name":"Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)","funder_award_id":"UL1RR025741","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8168629907","display_name":"The Prostate Cancer Tumor Microenvironment Exhibits Differentially Expressed Gene","funder_award_id":"U01CA152738","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320313816","display_name":"NorthShore University HealthSystem","ror":"https://ror.org/04tpp9d61"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978687013.pdf","grobid_xml":"https://content.openalex.org/works/W1978687013.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W34668368","https://openalex.org/W127659990","https://openalex.org/W1552528612","https://openalex.org/W1576274197","https://openalex.org/W1585338920","https://openalex.org/W1588226643","https://openalex.org/W1598913124","https://openalex.org/W1624649331","https://openalex.org/W1951412780","https://openalex.org/W1963567995","https://openalex.org/W1982188814","https://openalex.org/W1993774063","https://openalex.org/W1993817279","https://openalex.org/W2002443133","https://openalex.org/W2017515560","https://openalex.org/W2020699105","https://openalex.org/W2034602099","https://openalex.org/W2035296002","https://openalex.org/W2037943063","https://openalex.org/W2041500200","https://openalex.org/W2044347917","https://openalex.org/W2044474149","https://openalex.org/W2054111192","https://openalex.org/W2054742531","https://openalex.org/W2056222242","https://openalex.org/W2059598057","https://openalex.org/W2060446375","https://openalex.org/W2074496710","https://openalex.org/W2075704804","https://openalex.org/W2095004302","https://openalex.org/W2107038650","https://openalex.org/W2109197125","https://openalex.org/W2110617603","https://openalex.org/W2117059020","https://openalex.org/W2120751702","https://openalex.org/W2123095447","https://openalex.org/W2128194268","https://openalex.org/W2130539172","https://openalex.org/W2135213538","https://openalex.org/W2159087758","https://openalex.org/W2161186807","https://openalex.org/W2163240418","https://openalex.org/W2313078897","https://openalex.org/W2331369924","https://openalex.org/W2469149185","https://openalex.org/W2742932407","https://openalex.org/W2743648184"],"related_works":["https://openalex.org/W7098363954","https://openalex.org/W2325282712","https://openalex.org/W1514244537","https://openalex.org/W2082978296","https://openalex.org/W1986550820","https://openalex.org/W1999780885","https://openalex.org/W67968860","https://openalex.org/W2059600610","https://openalex.org/W2317076919","https://openalex.org/W1572407517"],"abstract_inverted_index":{"BACKGROUND:":[0],"DNA":[1],"methyltransferase":[2],"(DNMT)":[3],"is":[4,271,287],"one":[5],"of":[6,13,30,35,45,59,84,94,104,111,146,164,180,191,194,205,208,224,235,266,275,282],"the":[7,11,57,92,108,121,178,189,202,264,279],"major":[8],"factors":[9],"mediating":[10],"methylation":[12,102,274],"cancer":[14,40,161],"related":[15],"genes":[16],"such":[17],"as":[18],"TGF-\u03b2":[19,36,90,105,142,165,196,209,261],"receptors":[20,106,277],"(T\u03b2Rs).":[21],"This":[22],"in":[23,27,37,48,62,96,113,116,177,184,188,210,215,230,268],"turn":[24],"may":[25,262,297],"result":[26],"a":[28,174,185],"loss":[29],"sensitivity":[31],"to":[32,87,153],"physiologic":[33],"levels":[34],"aggressive":[38,136,159,280],"prostate":[39,155,160,250],"(CaP).":[41],"The":[42],"specific":[43],"mechanisms":[44],"DNMT's":[46],"role":[47],"CaP":[49,63,78,112,137,213,259,269,302],"remain":[50],"undetermined.":[51],"In":[52,284],"this":[53],"study,":[54],"we":[55,119],"describe":[56,88],"mechanism":[58],"TGF-\u03b2-mediated":[60],"DNMT":[61,95,124,199],"and":[64,98,107,115,126,157,226,228,278,296,304],"its":[65,99,276],"association":[66,122],"with":[67,81,173,222,243,273],"clinical":[68,127,299],"outcomes":[69],"following":[70,246],"radical":[71,130],"prostatectomy.":[72,131],"METHODOLOGY/PRINCIPAL":[73],"FINDINGS:":[74],"We":[75,132],"used":[76],"human":[77],"cell":[79],"lines":[80],"varying":[82],"degrees":[83],"invasive":[85,109,203],"capability":[86,110],"how":[89],"mediates":[91],"expression":[93,125,145,179,190,240,265],"CaP,":[97],"effects":[100],"on":[101],"status":[103],"vitro":[114],"vivo.":[117],"Furthermore,":[118],"determined":[120],"between":[123],"outcome":[128],"after":[129,294],"found":[133],"that":[134,258],"more":[135],"cells":[138,156],"had":[139],"significantly":[140],"higher":[141],"levels,":[143],"increased":[144,238],"DNMT,":[147,181],"but":[148],"reduced":[149],"T\u03b2Rs":[150],"when":[151],"compared":[152],"benign":[154],"less":[158],"cells.":[162],"Blockade":[163,193],"signaling":[166,197],"or":[167,198],"ERK":[168],"activation":[169],"(p-ERK)":[170],"was":[171,220,241],"associated":[172,221,242,272],"dramatic":[175],"decrease":[176],"which":[182,270],"results":[183],"coincident":[186],"increase":[187],"T\u03b2Rs.":[192],"either":[195],"dramatically":[200],"decreased":[201],"capabilities":[204],"CaP.":[206,283],"Inhibition":[207],"an":[211,288],"TRAMP-C2":[212],"model":[214],"C57BL/6":[216],"mice":[217],"using":[218],"1D11":[219],"downregulation":[223],"DNMTs":[225,267,286],"p-ERK":[227],"impairment":[229],"tumor":[231],"growth.":[232],"Finally,":[233],"independent":[234,289],"Gleason":[236],"grade,":[237],"DNMT1":[239],"biochemical":[244],"recurrence":[245,293],"surgical":[247],"treatment":[248],"for":[249,291,301],"cancer.":[251],"CONCLUSIONS":[252],"AND":[253],"SIGNIFICANCE:":[254],"Our":[255],"findings":[256],"demonstrate":[257],"derived":[260],"induce":[263],"potential":[281],"addition,":[285],"predictor":[290],"disease":[292],"prostatectomy,":[295],"have":[298],"implications":[300],"prognostication":[303],"therapy.":[305]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}