{"id":"https://openalex.org/W1978684374","doi":"https://doi.org/10.1590/s0100-879x1998001200006","title":"Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic \u00df-cell demand in men","display_name":"Low levels of sex hormone-binding globulin and hyperproinsulinemia as markers of increased pancreatic \u00df-cell demand in men","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W1978684374","doi":"https://doi.org/10.1590/s0100-879x1998001200006","mag":"1978684374","pmid":"https://pubmed.ncbi.nlm.nih.gov/9951550"},"language":"en","primary_location":{"id":"doi:10.1590/s0100-879x1998001200006","doi":"https://doi.org/10.1590/s0100-879x1998001200006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0100-879x1998001200006","pdf_url":"https://www.scielo.br/j/bjmbr/a/9kzpbcF4cHDqknTDbJwrFxc/?lang=en&format=pdf","source":{"id":"https://openalex.org/S183843087","display_name":"Brazilian Journal of Medical and Biological Research","issn_l":"0100-879X","issn":["0100-879X","1414-431X","1678-4510"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","medline","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310311980","host_organization_name":"Associa\u00e7\u00e3o Brasileira de Divulga\u00e7\u00e3o Cient\u00edfica","host_organization_lineage":["https://openalex.org/P4310311980"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Brasileira de Divulga\u00e7\u00e3o Cient\u00edfica"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Medical and Biological Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.scielo.br/j/bjmbr/a/9kzpbcF4cHDqknTDbJwrFxc/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110686396","display_name":"Andr\u00e9 Fernandes Reis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A.F. Reis","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087790576","display_name":"Walk\u00edria L. Miranda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"W.L. Miranda","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047323233","display_name":"Ant\u00f4nio Roberto Chacra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"A.R. Chacra","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":{"value":3300,"currency":"BRL","value_usd":1600},"apc_paid":{"value":3300,"currency":"BRL","value_usd":1600},"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"31","issue":"12","first_page":"1545","last_page":"1551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.05420000106096268,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":1.0},{"id":"https://openalex.org/keywords/proinsulin","display_name":"proinsulin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.8420000076293945},{"id":"https://openalex.org/keywords/beta-cell-secretion","display_name":"beta-cell secretion","score":0.656000018119812},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5550000071525574},{"id":"https://openalex.org/keywords/c-peptide","display_name":"C-peptide","score":0.8220000267028809},{"id":"https://openalex.org/keywords/insulin-levels","display_name":"insulin levels","score":0.6029999852180481},{"id":"https://openalex.org/keywords/type-2-diabetes-risk","display_name":"type 2 diabetes risk","score":0.7580000162124634},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.7139999866485596},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C90061646","wikidata":"https://www.wikidata.org/wiki/Q426173","display_name":"Proinsulin","level":3,"score":0.9562214612960815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8492801189422607},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8237560987472534},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.7540035247802734},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.6814055442810059},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6181809306144714},{"id":"https://openalex.org/C2778875212","wikidata":"https://www.wikidata.org/wiki/Q419107","display_name":"C-peptide","level":3,"score":0.6134328842163086},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.563740611076355},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5201314091682434},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.49193668365478516},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.482048362493515},{"id":"https://openalex.org/C2780090379","wikidata":"https://www.wikidata.org/wiki/Q419119","display_name":"Prohormone","level":3,"score":0.4742625951766968},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.4391515851020813},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3726055324077606},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011384","descriptor_name":"Proinsulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1590/s0100-879x1998001200006","doi":"https://doi.org/10.1590/s0100-879x1998001200006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0100-879x1998001200006","pdf_url":"https://www.scielo.br/j/bjmbr/a/9kzpbcF4cHDqknTDbJwrFxc/?lang=en&format=pdf","source":{"id":"https://openalex.org/S183843087","display_name":"Brazilian Journal of Medical and Biological Research","issn_l":"0100-879X","issn":["0100-879X","1414-431X","1678-4510"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","medline","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310311980","host_organization_name":"Associa\u00e7\u00e3o Brasileira de Divulga\u00e7\u00e3o Cient\u00edfica","host_organization_lineage":["https://openalex.org/P4310311980"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Brasileira de Divulga\u00e7\u00e3o Cient\u00edfica"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Medical and Biological Research","raw_type":"journal-article"},{"id":"pmid:9951550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9951550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas","raw_type":"Comparative Study"},{"id":"pmh:oai:scielo:S0100-879X1998001200006","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0100-879X1998001200006","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Medical and Biological Research v.31 n.12 1998","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.865.3405","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.865.3405","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.scielo.br/pdf/bjmbr/v31n12/3156c.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:2660526","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200006","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brazilian Journal of Medical and Biological Research v.31 n.12 1998","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2786956","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=2786956","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:10b4512165ce4c1bbeb3e677a28bd30d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10b4512165ce4c1bbeb3e677a28bd30d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brazilian Journal of Medical and Biological Research, Vol 31, Iss 12, p 1545 (1998)","raw_type":"article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/700","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/700","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2185094262","doi":null,"is_oa":false,"landing_page_url":"http://scielo.br/pdf/bjmbr/v31n12/3156c.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1590/s0100-879x1998001200006","doi":"https://doi.org/10.1590/s0100-879x1998001200006","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0100-879x1998001200006","pdf_url":"https://www.scielo.br/j/bjmbr/a/9kzpbcF4cHDqknTDbJwrFxc/?lang=en&format=pdf","source":{"id":"https://openalex.org/S183843087","display_name":"Brazilian Journal of Medical and Biological Research","issn_l":"0100-879X","issn":["0100-879X","1414-431X","1678-4510"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","medline","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310311980","host_organization_name":"Associa\u00e7\u00e3o Brasileira de Divulga\u00e7\u00e3o Cient\u00edfica","host_organization_lineage":["https://openalex.org/P4310311980"],"host_organization_lineage_names":["Associa\u00e7\u00e3o Brasileira de Divulga\u00e7\u00e3o Cient\u00edfica"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Medical and Biological Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978684374.pdf","grobid_xml":"https://content.openalex.org/works/W1978684374.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1967841225","https://openalex.org/W1974313427","https://openalex.org/W1974554536","https://openalex.org/W1975926470","https://openalex.org/W1983820580","https://openalex.org/W1994232615","https://openalex.org/W1995065100","https://openalex.org/W1998659990","https://openalex.org/W2001666927","https://openalex.org/W2008618446","https://openalex.org/W2017138053","https://openalex.org/W2018594232","https://openalex.org/W2023513779","https://openalex.org/W2026388701","https://openalex.org/W2036161100","https://openalex.org/W2036203117","https://openalex.org/W2045243414","https://openalex.org/W2046889389","https://openalex.org/W2056158111","https://openalex.org/W2066701642","https://openalex.org/W2067539975","https://openalex.org/W2081593728","https://openalex.org/W2084009063","https://openalex.org/W2087471461","https://openalex.org/W2110825938","https://openalex.org/W2120134933","https://openalex.org/W2166766026","https://openalex.org/W2341411724","https://openalex.org/W2410873633"],"related_works":["https://openalex.org/W3084052876","https://openalex.org/W2170884494","https://openalex.org/W2155219543","https://openalex.org/W2036161100","https://openalex.org/W2091284828","https://openalex.org/W1969126041","https://openalex.org/W2375286854","https://openalex.org/W1975586273","https://openalex.org/W2142590388","https://openalex.org/W2145774780"],"abstract_inverted_index":{"Low":[0],"levels":[1,214,257,269,288],"of":[2,14,20,34,179,215,262,293],"sex":[3],"hormone-binding":[4],"globulin":[5],"(SHBG)":[6],"are":[7,289],"considered":[8],"to":[9,90,95,111],"be":[10],"an":[11,35,96],"indirect":[12],"index":[13],"hyperinsulinemia,":[15],"predicting":[16],"the":[17,26,32,52,57,176,220,239,276,283],"later":[18],"onset":[19],"diabetes":[21],"mellitus":[22],"type":[23],"2.":[24],"In":[25,51],"insulin":[27,128,236,247],"resistance":[28],"state":[29],"and":[30,44,61,82,103,105,115,149,200,232,235,255,270],"in":[31,47,65,219],"presence":[33],"increased":[36,294],"pancreatic":[37,62,271,295],"beta-cell":[38,63,272,296],"demand":[39],"(e.g.":[40],"obesity)":[41],"both":[42],"absolute":[43],"relative":[45],"increases":[46],"proinsulin":[48,114,135,152,170,234,280],"secretion":[49,64],"occur.":[50],"present":[53],"study":[54],"we":[55],"investigated":[56],"correlation":[58,252,266],"between":[59,253,267],"SHBG":[60,121,180,216,256,268,287],"men":[66,73],"with":[67,78,126,151],"different":[68],"body":[69,83],"compositions.":[70],"Eighteen":[71],"young":[72],"(30.0":[74],"+/-":[75],"2.4":[76],"years)":[77],"normal":[79],"glucose":[80,98,157],"tolerance":[81,99],"mass":[84],"indexes":[85],"(BMI)":[86],"ranging":[87],"from":[88],"22.6":[89],"43.2":[91],"kg/m2":[92],"were":[93,109,123,175,189,217],"submitted":[94],"oral":[97],"test":[100],"(75":[101],"g)":[102],"baseline":[104,127,229],"120-min":[106,233,277],"blood":[107],"samples":[108],"used":[110],"determine":[112],"insulin,":[113],"C-peptide":[116,142,231],"by":[117],"specific":[118,244],"immunoassays.":[119],"Baseline":[120],"values":[122,171],"significantly":[124,212,227],"correlated":[125],"(r":[129,136,143,159,181],"=":[130,137,144,160,182,198,205,209],"-0.58,":[131,161,183],"P":[132,139,146,162,184],"<":[133,140,147,163,185,203],"0.05),":[134,141],"-0.47,":[138],"-0.55,":[145],"0.05)":[148],"also":[150],"at":[153,172],"120":[154,173],"min":[155,174],"after":[156],"load":[158,279],"0.05).":[164,186],"Stepwise":[165],"regression":[166],"analysis":[167],"revealed":[168],"that":[169,285],"strongest":[177],"predictor":[178],"When":[187],"subjects":[188],"divided":[190],"into":[191],"obese":[192,221,224],"(BMI":[193,202],">":[194],"28":[195],"kg/m2,":[196,207],"N":[197,208],"8)":[199],"nonobese":[201],"or":[204],"25":[206],"10)":[210],"groups,":[211],"lower":[213],"found":[218],"subjects.":[222],"The":[223,260],"group":[225],"had":[226],"higher":[228],"proinsulin,":[230],"levels.":[237],"For":[238],"first":[240],"time":[241],"using":[242],"a":[243,249,263,290],"assay":[245],"for":[246,275],"determination,":[248],"strong":[250,264],"inverse":[251],"insulinemia":[254],"was":[258],"confirmed.":[259],"finding":[261],"negative":[265],"secretion,":[273],"mainly":[274],"post-glucose":[278],"levels,":[281],"reinforces":[282],"concept":[284],"low":[286],"suitable":[291],"marker":[292],"demand.":[297]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
