{"id":"https://openalex.org/W1978671007","doi":"https://doi.org/10.1016/s0032-9592(03)00057-8","title":"Response surface methodological approach to optimize the nutritional parameters for neomycin production by Streptomyces marinensis under solid-state fermentation","display_name":"Response surface methodological approach to optimize the nutritional parameters for neomycin production by Streptomyces marinensis under solid-state fermentation","publication_year":2003,"publication_date":"2003-04-07","ids":{"openalex":"https://openalex.org/W1978671007","doi":"https://doi.org/10.1016/s0032-9592(03)00057-8","mag":"1978671007"},"language":"en","primary_location":{"id":"doi:10.1016/s0032-9592(03)00057-8","doi":"https://doi.org/10.1016/s0032-9592(03)00057-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0032-9592(03)00057-8","pdf_url":null,"source":{"id":"https://openalex.org/S173499201","display_name":"Process Biochemistry","issn_l":"0032-9592","issn":["0032-9592","1359-5113","1873-3298"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Process Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057953608","display_name":"Adinarayana Kunamneni","orcid":"https://orcid.org/0000-0002-9952-2209","observed_orcids":["https://orcid.org/0000-0002-9952-2209"]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K Adinarayana","raw_affiliation_strings":["Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India","institution_ids":["https://openalex.org/I100887729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044703577","display_name":"Poluri Ellaiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"P Ellaiah","raw_affiliation_strings":["Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India","institution_ids":["https://openalex.org/I100887729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109239389","display_name":"Bandi Srinivasulu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B Srinivasulu","raw_affiliation_strings":["Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India","institution_ids":["https://openalex.org/I100887729"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051537959","display_name":"R Bhavani Devi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R Bhavani Devi","raw_affiliation_strings":["Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India","institution_ids":["https://openalex.org/I100887729"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019192210","display_name":"G Adinarayana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G Adinarayana","raw_affiliation_strings":["Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, India","institution_ids":["https://openalex.org/I100887729"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044703577"],"corresponding_institution_ids":["https://openalex.org/I100887729"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":5.3705,"has_fulltext":false,"cited_by_count":179,"citation_normalized_percentile":{"value":0.9732665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"38","issue":"11","first_page":"1565","last_page":"1572"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solid-state-fermentation","display_name":"solid-state fermentation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antibiotic-production-optimization","display_name":"antibiotic production optimization","score":0.621999979019165},{"id":"https://openalex.org/keywords/dextrin","display_name":"dextrin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mineral-medium","display_name":"mineral medium","score":0.6959999799728394},{"id":"https://openalex.org/keywords/fermentation-medium-optimization","display_name":"fermentation medium optimization","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C2778254848","wikidata":"https://www.wikidata.org/wiki/Q191978","display_name":"Dextrin","level":3,"score":0.8588979244232178},{"id":"https://openalex.org/C2779841869","wikidata":"https://www.wikidata.org/wiki/Q423098","display_name":"Neomycin","level":3,"score":0.7723945379257202},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.6955789923667908},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.610144317150116},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.595260739326477},{"id":"https://openalex.org/C92397422","wikidata":"https://www.wikidata.org/wiki/Q5062082","display_name":"Central composite design","level":3,"score":0.5898661017417908},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5094590783119202},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.4922012388706207},{"id":"https://openalex.org/C2779942233","wikidata":"https://www.wikidata.org/wiki/Q7557796","display_name":"Solid-state fermentation","level":3,"score":0.48748135566711426},{"id":"https://openalex.org/C111425208","wikidata":"https://www.wikidata.org/wiki/Q1130485","display_name":"Blowing a raspberry","level":2,"score":0.44603657722473145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4308106601238251},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.404170960187912},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33235758543014526},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2701399326324463},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2649281620979309},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25958216190338135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2533721327781677},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07793566584587097},{"id":"https://openalex.org/C529335014","wikidata":"https://www.wikidata.org/wiki/Q41534","display_name":"Starch","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0032-9592(03)00057-8","doi":"https://doi.org/10.1016/s0032-9592(03)00057-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0032-9592(03)00057-8","pdf_url":null,"source":{"id":"https://openalex.org/S173499201","display_name":"Process Biochemistry","issn_l":"0032-9592","issn":["0032-9592","1359-5113","1873-3298"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Process Biochemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7142999768257141,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W129367500","https://openalex.org/W1559430814","https://openalex.org/W1578117524","https://openalex.org/W1587419293","https://openalex.org/W1971890166","https://openalex.org/W1975372142","https://openalex.org/W1980685869","https://openalex.org/W1984390795","https://openalex.org/W1985504480","https://openalex.org/W2002758667","https://openalex.org/W2004844372","https://openalex.org/W2007957546","https://openalex.org/W2008495313","https://openalex.org/W2010762682","https://openalex.org/W2039970428","https://openalex.org/W2055180707","https://openalex.org/W2066351651","https://openalex.org/W2073578738","https://openalex.org/W2095438071","https://openalex.org/W2237440835","https://openalex.org/W2410737264"],"related_works":["https://openalex.org/W2096648228","https://openalex.org/W7100721631","https://openalex.org/W2031534795","https://openalex.org/W2758681158","https://openalex.org/W4395693454","https://openalex.org/W2113448162","https://openalex.org/W1980539866","https://openalex.org/W2365817519","https://openalex.org/W2167992780","https://openalex.org/W2184565792"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}