{"id":"https://openalex.org/W1978650451","doi":"https://doi.org/10.1109/wacv.2015.64","title":"Classification of 3D Multicellular Organization in Phase Microscopy for High Throughput Screening of Therapeutic Targets","display_name":"Classification of 3D Multicellular Organization in Phase Microscopy for High Throughput Screening of Therapeutic Targets","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1978650451","doi":"https://doi.org/10.1109/wacv.2015.64","mag":"1978650451","pmid":"https://pubmed.ncbi.nlm.nih.gov/25729338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4341969"},"language":"en","primary_location":{"id":"doi:10.1109/wacv.2015.64","doi":"https://doi.org/10.1109/wacv.2015.64","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wacv.2015.64","pdf_url":null,"source":{"id":"https://openalex.org/S4393918690","display_name":"IEEE Winter Conference on Applications of Computer Vision","issn_l":"2472-6737","issn":["2472-6737"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE Winter Conference on Applications of Computer Vision","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4341969","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047619963","display_name":"Hang Chang","orcid":"https://orcid.org/0000-0002-3773-6818","observed_orcids":["https://orcid.org/0000-0002-3773-6818"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hang Chang","raw_affiliation_strings":["Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, U.S.A","Department of Electrical and Computer Engineering, University of California, Riverside, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, U.S.A","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, Riverside, U.S.A","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053749724","display_name":"Bahram Parvin","orcid":"https://orcid.org/0000-0002-6433-8006","observed_orcids":["https://orcid.org/0000-0002-6433-8006"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I134113660","display_name":"University of Nevada, Reno","ror":"https://ror.org/01keh0577","country_code":"US","type":"education","lineage":["https://openalex.org/I134113660"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bahram Parvin","raw_affiliation_strings":["Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, U.S.A ; Biomedical Engineering Department, University of Nevada, Reno, Nevada, U.S.A","Department of Biomedical Engineering, University of Nevada, Reno, Nevada, U.S.A","Department of Electrical and Computer Engineering, University of California, Riverside, U.S.A","Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, U.S.A ; Biomedical Engineering Department, University of Nevada, Reno, Nevada, U.S.A","institution_ids":["https://openalex.org/I134113660","https://openalex.org/I148283060"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Nevada, Reno, Nevada, U.S.A","institution_ids":["https://openalex.org/I134113660"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of California, Riverside, U.S.A","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, U.S.A","institution_ids":["https://openalex.org/I148283060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9093,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.69023324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"30","issue":null,"first_page":"436","last_page":"441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phase-contrast-microscopy","display_name":"phase contrast microscopy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8560000061988831},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.593999981880188},{"id":"https://openalex.org/keywords/3d-cell-culture-models","display_name":"3D cell culture models","score":0.7639999985694885},{"id":"https://openalex.org/keywords/sift-features","display_name":"SIFT features","score":0.8560000061988831},{"id":"https://openalex.org/keywords/sparse-coding","display_name":"sparse coding","score":0.7419999837875366},{"id":"https://openalex.org/keywords/spatial-pyramid-matching","display_name":"spatial pyramid matching","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tumor-cell-differentiation","display_name":"tumor cell differentiation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6722341775894165},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5796351432800293},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5756779313087463},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.468887060880661},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.46615490317344666},{"id":"https://openalex.org/C163688615","wikidata":"https://www.wikidata.org/wiki/Q15883629","display_name":"3D cell culture","level":3,"score":0.4595761001110077},{"id":"https://openalex.org/C2779808786","wikidata":"https://www.wikidata.org/wiki/Q6664603","display_name":"Locality","level":2,"score":0.4560111165046692},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.41551363468170166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22611874341964722},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.12441346049308777},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11990490555763245},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10110139846801758},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1109/wacv.2015.64","doi":"https://doi.org/10.1109/wacv.2015.64","is_oa":false,"landing_page_url":"https://doi.org/10.1109/wacv.2015.64","pdf_url":null,"source":{"id":"https://openalex.org/S4393918690","display_name":"IEEE Winter Conference on Applications of Computer Vision","issn_l":"2472-6737","issn":["2472-6737"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 IEEE Winter Conference on Applications of Computer Vision","raw_type":"proceedings-article"},{"id":"pmid:25729338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25729338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings. IEEE Workshop on Applications of Computer Vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4341969","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4341969","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proc IEEE Workshop Appl Comput Vis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4341969","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4341969","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proc IEEE Workshop Appl Comput Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","score":0.5699999928474426,"display_name":"Peace, justice, and strong institutions"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6785568758","display_name":"High Content Representation and Association of 3D Cell Culture Models","funder_award_id":"R01CA140663","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W6585196","https://openalex.org/W1624854622","https://openalex.org/W1967293289","https://openalex.org/W2003921795","https://openalex.org/W2027922120","https://openalex.org/W2033474014","https://openalex.org/W2037227137","https://openalex.org/W2054922344","https://openalex.org/W2086336448","https://openalex.org/W2097018403","https://openalex.org/W2101187282","https://openalex.org/W2109187183","https://openalex.org/W2114123948","https://openalex.org/W2118585731","https://openalex.org/W2124386111","https://openalex.org/W2134563198","https://openalex.org/W2150112333","https://openalex.org/W2150170882","https://openalex.org/W2152315187","https://openalex.org/W2160547390","https://openalex.org/W2162915993","https://openalex.org/W2163137692","https://openalex.org/W2163181242","https://openalex.org/W2167284102","https://openalex.org/W2186094539","https://openalex.org/W2258617909","https://openalex.org/W2546302380","https://openalex.org/W4232730838","https://openalex.org/W6686583229"],"related_works":["https://openalex.org/W2031604576","https://openalex.org/W593764432","https://openalex.org/W4408145112","https://openalex.org/W4297796330","https://openalex.org/W1969545640","https://openalex.org/W2900641222","https://openalex.org/W2334690871","https://openalex.org/W2015547418","https://openalex.org/W7128623554","https://openalex.org/W4390189691"],"abstract_inverted_index":{"The":[0],"current":[1],"trend":[2],"in":[3,25,59,65,110,163],"high":[4,122],"throughput":[5],"screening":[6,86],"is":[7],"the":[8,66,72,104,131,136,154,161,164],"utilization":[9],"of":[10,22,56,68,106,157],"more":[11],"complex":[12],"model":[13],"systems":[14,38],"that":[15,53],"mimic":[16],"both":[17],"structural":[18],"and":[19,43,64,134,142],"functional":[20],"properties":[21],"cellular":[23],"processes":[24],"vivo.":[26],"In":[27,90],"this":[28,91],"context,":[29],"3D":[30],"cell":[31],"culture":[32,60],"models":[33],"have":[34],"emerged":[35],"as":[36],"effective":[37],"to":[39,160],"study":[40],"tumor":[41],"initiation":[42],"cancer":[44,57],"behavior,":[45],"where":[46],"colony":[47,73,108],"organization":[48,74,109],"represents":[49],"distinct":[50],"phenotypic":[51],"signatures":[52],"enable":[54,83],"differentiation":[55],"cells":[58],"using":[61,87],"phase":[62,88,111],"imaging":[63],"absence":[67],"clinical":[69],"markers.":[70],"If":[71],"can":[75],"be":[76],"classified":[77],"into":[78,121],"different":[79],"phenotypes,":[80],"it":[81],"will":[82],"rapid":[84],"drug":[85],"microscopy.":[89],"paper,":[92],"we":[93],"propose":[94],"a":[95],"novel":[96],"method":[97],"based":[98],"on":[99,130],"locality-constrained":[100],"dictionary":[101],"learning":[102],"for":[103,148],"discrimination":[105],"aberrant":[107],"images,":[112],"which":[113],"encodes":[114],"original":[115],"SIFT":[116],"(Scale-Invariant":[117],"Feature":[118],"Transform)":[119],"features":[120,138],"dimensional":[123],"sparse":[124,137],"codes":[125],"with":[126],"locality-preserving":[127],"landmark":[128],"points":[129],"nonlinear":[132],"manifold,":[133],"summarizes":[135],"at":[139],"various":[140],"locations":[141],"scales":[143],"through":[144],"spatial":[145],"pyramid":[146],"matching":[147],"robust":[149],"representation.":[150],"Experimental":[151],"results":[152],"demonstrate":[153],"significant":[155],"improvement":[156],"performance,":[158],"compared":[159],"state-of-art":[162],"field.":[165]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}