{"id":"https://openalex.org/W1978646280","doi":"https://doi.org/10.1038/ncomms1766","title":"The self-interaction of native TDP-43 C terminus inhibits its degradation and contributes to early proteinopathies","display_name":"The self-interaction of native TDP-43 C terminus inhibits its degradation and contributes to early proteinopathies","publication_year":2012,"publication_date":"2012-04-03","ids":{"openalex":"https://openalex.org/W1978646280","doi":"https://doi.org/10.1038/ncomms1766","mag":"1978646280","pmid":"https://pubmed.ncbi.nlm.nih.gov/22473010"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms1766","doi":"https://doi.org/10.1038/ncomms1766","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms1766","pdf_url":"https://www.nature.com/articles/ncomms1766.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/ncomms1766.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083029385","display_name":"I\u2010Fan Wang","orcid":"https://orcid.org/0000-0002-6856-0691","observed_orcids":["https://orcid.org/0000-0002-6856-0691"]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"I.-Fan Wang","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan. mirna125@gmail.com","Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan. mirna125@gmail.com","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026945448","display_name":"Hsiang\u2010Yu Chang","orcid":"https://orcid.org/0000-0001-5369-4016","observed_orcids":["https://orcid.org/0000-0001-5369-4016"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210162664","display_name":"Garage Brain Science","ror":"https://ror.org/05aen6q52","country_code":"TW","type":"company","lineage":["https://openalex.org/I4210162664"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiang-Yu Chang","raw_affiliation_strings":["Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, 404, Taiwan","Garage Brain Science, Taichung, 413, Taiwan","Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan","Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan","Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, 404, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Garage Brain Science, Taichung, 413, Taiwan","institution_ids":["https://openalex.org/I4210162664"]},{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111556813","display_name":"Shin Chen Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210162664","display_name":"Garage Brain Science","ror":"https://ror.org/05aen6q52","country_code":"TW","type":"company","lineage":["https://openalex.org/I4210162664"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shin-Chen Hou","raw_affiliation_strings":["Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, 404, Taiwan","Garage Brain Science, Taichung, 413, Taiwan","Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, 404, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Garage Brain Science, Taichung, 413, Taiwan","institution_ids":["https://openalex.org/I4210162664"]},{"raw_affiliation_string":"Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041166904","display_name":"Gunn\u2010Guang Liou","orcid":"https://orcid.org/0000-0002-2619-8516","observed_orcids":["https://orcid.org/0000-0002-2619-8516"]},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Gunn-Guang Liou","raw_affiliation_strings":["Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, 350, Taiwan","Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, 350, Taiwan","institution_ids":["https://openalex.org/I165441096"]},{"raw_affiliation_string":"Institute of Molecular and Genomic Medicine National Health Research Institutes Miaoli Taiwan","institution_ids":["https://openalex.org/I165441096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049596761","display_name":"Tzong\u2010Der Way","orcid":"https://orcid.org/0000-0001-5934-0008","observed_orcids":["https://orcid.org/0000-0001-5934-0008"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tzong-Der Way","raw_affiliation_strings":["Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, 404, Taiwan","Department of Biological Science and Technology College of Life Sciences, China Medical University Taichung Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, 404, Taiwan","institution_ids":["https://openalex.org/I184693016"]},{"raw_affiliation_string":"Department of Biological Science and Technology College of Life Sciences, China Medical University Taichung Taiwan","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101648724","display_name":"C.\u2010K. James Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.-K. James Shen","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan","Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083029385"],"corresponding_institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":null,"fwci":5.1836,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.95938036,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"1","first_page":"766","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.9629999995231628},{"id":"https://openalex.org/keywords/c-terminal-fragment","display_name":"C-terminal fragment","score":0.7279999852180481},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/sup35","display_name":"Sup35","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":0.9380000233650208},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/proteinopathies","display_name":"proteinopathies","score":0.7369999885559082},{"id":"https://openalex.org/keywords/exon-skipping","display_name":"exon skipping","score":0.7049999833106995},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6669999957084656},{"id":"https://openalex.org/keywords/loss-of-function","display_name":"loss of function","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C57711820","wikidata":"https://www.wikidata.org/wiki/Q310425","display_name":"C-terminus","level":3,"score":0.5545163750648499},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5172010660171509},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.4971053898334503},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4955071210861206},{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.47162365913391113},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4714580178260803},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4700566530227661},{"id":"https://openalex.org/C140248907","wikidata":"https://www.wikidata.org/wiki/Q17913449","display_name":"DDB1","level":5,"score":0.46423545479774475},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.45982933044433594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4517847001552582},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.44333893060684204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41662466526031494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38671278953552246},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.20999354124069214},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.16764047741889954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16590037941932678},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/ncomms1766","doi":"https://doi.org/10.1038/ncomms1766","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms1766","pdf_url":"https://www.nature.com/articles/ncomms1766.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:22473010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22473010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1766","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms1766","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/ncomms1766","doi":"https://doi.org/10.1038/ncomms1766","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms1766","pdf_url":"https://www.nature.com/articles/ncomms1766.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3006427632","display_name":null,"funder_award_id":"NSC99","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"}],"funders":[{"id":"https://openalex.org/F4320320901","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219"},{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978646280.pdf","grobid_xml":"https://content.openalex.org/works/W1978646280.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1503622815","https://openalex.org/W1939575473","https://openalex.org/W1967932847","https://openalex.org/W1971323868","https://openalex.org/W1975860260","https://openalex.org/W1980675329","https://openalex.org/W1984145170","https://openalex.org/W1987301163","https://openalex.org/W1989172027","https://openalex.org/W1995496955","https://openalex.org/W1998038512","https://openalex.org/W2003618511","https://openalex.org/W2011358070","https://openalex.org/W2016332933","https://openalex.org/W2020159880","https://openalex.org/W2027720028","https://openalex.org/W2029374248","https://openalex.org/W2032469042","https://openalex.org/W2032719480","https://openalex.org/W2036568573","https://openalex.org/W2038004674","https://openalex.org/W2041451000","https://openalex.org/W2045962406","https://openalex.org/W2060076138","https://openalex.org/W2061429937","https://openalex.org/W2068111204","https://openalex.org/W2077624231","https://openalex.org/W2083310759","https://openalex.org/W2084578579","https://openalex.org/W2091934163","https://openalex.org/W2092662963","https://openalex.org/W2105495356","https://openalex.org/W2119651404","https://openalex.org/W2127282494","https://openalex.org/W2127861463","https://openalex.org/W2128817844","https://openalex.org/W2130350273","https://openalex.org/W2131725903","https://openalex.org/W2135893969","https://openalex.org/W2136949432","https://openalex.org/W2139267086","https://openalex.org/W2142038032","https://openalex.org/W2143958500","https://openalex.org/W2146865209","https://openalex.org/W2147297400","https://openalex.org/W2149541702","https://openalex.org/W2157450464","https://openalex.org/W2169033090","https://openalex.org/W2169158245"],"related_works":["https://openalex.org/W2871983183","https://openalex.org/W7098569217","https://openalex.org/W4211206851","https://openalex.org/W2341346355","https://openalex.org/W1994982825","https://openalex.org/W7164832530","https://openalex.org/W4226261762","https://openalex.org/W2160311330","https://openalex.org/W2050790612","https://openalex.org/W2131725903"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}