{"id":"https://openalex.org/W1978646235","doi":"https://doi.org/10.1371/journal.pone.0057206","title":"Biological Mechanisms Underlying Structural Changes Induced by Colorectal Field Carcinogenesis Measured with Low-Coherence Enhanced Backscattering (LEBS) Spectroscopy","display_name":"Biological Mechanisms Underlying Structural Changes Induced by Colorectal Field Carcinogenesis Measured with Low-Coherence Enhanced Backscattering (LEBS) Spectroscopy","publication_year":2013,"publication_date":"2013-02-19","ids":{"openalex":"https://openalex.org/W1978646235","doi":"https://doi.org/10.1371/journal.pone.0057206","mag":"1978646235","pmid":"https://pubmed.ncbi.nlm.nih.gov/23431406","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3576387"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0057206","doi":"https://doi.org/10.1371/journal.pone.0057206","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0057206","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057206&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057206&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021454424","display_name":"Nikhil N. Mutyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil N. Mutyal","raw_affiliation_strings":["Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086495244","display_name":"Andrew J. Radosevich","orcid":"https://orcid.org/0000-0003-4435-6749","observed_orcids":["https://orcid.org/0000-0003-4435-6749"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Radosevich","raw_affiliation_strings":["Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051201314","display_name":"Ashish K. Tiwari","orcid":"https://orcid.org/0000-0002-0167-3165","observed_orcids":["https://orcid.org/0000-0002-0167-3165"]},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"Endeavor Health","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish K. Tiwari","raw_affiliation_strings":["Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I1339509835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021557611","display_name":"Yolanda E. Stypula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yolanda Stypula","raw_affiliation_strings":["Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111711810","display_name":"Ramesh K. Wali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"Endeavor Health","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramesh Wali","raw_affiliation_strings":["Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I1339509835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002057500","display_name":"Dhananjay P. Kunte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"Endeavor Health","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhananjay Kunte","raw_affiliation_strings":["Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I1339509835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062415571","display_name":"Hemant K. Roy","orcid":"https://orcid.org/0000-0002-6342-6768","observed_orcids":["https://orcid.org/0000-0002-6342-6768","https://orcid.org/0000-0001-7613-5575"]},"institutions":[{"id":"https://openalex.org/I1339509835","display_name":"Endeavor Health","ror":"https://ror.org/04tpp9d61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339509835"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hemant K. Roy","raw_affiliation_strings":["Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, NorthShore University Healthsystems, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I1339509835"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004008868","display_name":"Vadim Backman","orcid":"https://orcid.org/0000-0003-1981-1818","observed_orcids":["https://orcid.org/0000-0003-1981-1818"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vadim Backman","raw_affiliation_strings":["Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062415571"],"corresponding_institution_ids":["https://openalex.org/I1339509835"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.1354,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.84941261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"2","first_page":"e57206","last_page":"e57206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.2930000126361847,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colonic-epithelial-cells","display_name":"colonic epithelial cells","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.6819999814033508},{"id":"https://openalex.org/keywords/azoxymethane","display_name":"azoxymethane","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.8220000267028809},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7184178829193115},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5543031692504883},{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.4884249269962311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4821490943431854},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46805518865585327},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.43440133333206177},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4258882999420166},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.41257244348526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34111401438713074},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3205130100250244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29095667600631714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28152963519096375},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.19640108942985535},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16857221722602844},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11886689066886902}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001397","descriptor_name":"Azoxymethane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012542","descriptor_name":"Scattering, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013053","descriptor_name":"Spectrophotometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050257","descriptor_name":"Tubulin Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0057206","doi":"https://doi.org/10.1371/journal.pone.0057206","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0057206","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057206&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2576416","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3576387","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3576387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3576387","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23431406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23431406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.5909","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.5909","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c1/96/pone.0057206.PMC3576387.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9475103ae7b9422c9f1f0016771e1eda","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9475103ae7b9422c9f1f0016771e1eda","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 2, p e57206 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0057206","doi":"https://doi.org/10.1371/journal.pone.0057206","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0057206","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057206&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G393270307","display_name":"EFRI-BSBA: Photonic Technique for Sensing and Understanding Subcellular Structures at Nanoscale","funder_award_id":"0937987","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4926156747","display_name":"Spectral Markers for Early Detection of Colon Neoplasia","funder_award_id":"U01CA111257","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G539524280","display_name":null,"funder_award_id":"R01 EB003682","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6717066942","display_name":"Mechanisms of Light Scattering in Living Tissue","funder_award_id":"R01EB003682","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G7713630678","display_name":"Novel Biophotonics Methodology for Colon Cancer Screening","funder_award_id":"R01CA128641","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7822012037","display_name":"Transforming Colorectal Cancer Screening through Multimodal Spectral Markers","funder_award_id":"R01CA156186","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978646235.pdf","grobid_xml":"https://content.openalex.org/works/W1978646235.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1493798677","https://openalex.org/W1846418786","https://openalex.org/W1899139931","https://openalex.org/W1995153837","https://openalex.org/W1997237151","https://openalex.org/W2009190319","https://openalex.org/W2031372290","https://openalex.org/W2035503012","https://openalex.org/W2036891408","https://openalex.org/W2044364925","https://openalex.org/W2062899330","https://openalex.org/W2070069066","https://openalex.org/W2071206356","https://openalex.org/W2073495867","https://openalex.org/W2079883750","https://openalex.org/W2080049513","https://openalex.org/W2082189609","https://openalex.org/W2100594722","https://openalex.org/W2111808908","https://openalex.org/W2112452658","https://openalex.org/W2120045074","https://openalex.org/W2121428123","https://openalex.org/W2132373340","https://openalex.org/W2144520732","https://openalex.org/W2147592763","https://openalex.org/W2152785381","https://openalex.org/W2153786946","https://openalex.org/W2160340382","https://openalex.org/W2161867610","https://openalex.org/W2163549086","https://openalex.org/W2166369947","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7096408001","https://openalex.org/W2144520732","https://openalex.org/W2086248090","https://openalex.org/W2136461483","https://openalex.org/W1987596186","https://openalex.org/W2100594722","https://openalex.org/W2125388587","https://openalex.org/W2165845406","https://openalex.org/W2167490656","https://openalex.org/W2118425778"],"abstract_inverted_index":{"We":[0,36,113,197],"previously":[1,153],"reported":[2,154],"the":[3,24,32,39,98,102,167,175,178,195,212,218,227],"utility":[4],"of":[5,23,26,68,117,140,177,186,194,238],"Low-Coherence":[6],"Enhanced":[7],"Backscattering":[8],"(LEBS)":[9],"Spectroscopy":[10],"in":[11,15,31,41,49,64,77,80,94,105,123,126,149,159,164,180,183,201,217,230],"detecting":[12],"optical":[13,42,184,202,219],"changes":[14,19,48,93,182],"uninvolved":[16],"rectal":[17],"mucosa,":[18],"that":[20,38,137,199],"are":[21,44,147,162],"indicative":[22],"presence":[25],"advanced":[27],"colorectal":[28,69,127,248],"adenomas":[29],"elsewhere":[30],"colon":[33,145,232],"(field":[34],"carcinogenesis).":[35],"hypothesized":[37],"alterations":[40,229],"signatures":[43],"due":[45],"to":[46,92,143,155,246],"structural":[47],"colonocytes.":[50,95],"To":[51,96,172],"elucidate":[52],"those":[53],"colonocyte":[54,103],"changes,":[55],"we":[56,108,188],"used":[57,189],"LEBS":[58,78],"and":[59,151,206,234,241],"an":[60,65],"early":[61,231],"time":[62],"point":[63],"animal":[66],"model":[67],"field":[70],"carcinogenesis--rats":[71],"treated":[72],"with":[73],"azoxymethane":[74],"(AOM).":[75],"Changes":[76],"markers":[79,185,203],"intact":[81],"mucosa":[82],"from":[83,129],"AOM-treated":[84,132],"rats":[85],"could":[86],"be":[87,156],"at":[88],"least":[89],"partially":[90],"attributed":[91],"investigate":[97],"molecular":[99,242],"mechanisms":[100],"underlying":[101],"abnormalities":[104],"premalignant":[106],"colon,":[107],"took":[109],"a":[110,138],"candidate":[111],"approach.":[112],"compared":[114],"expression":[115],"profiles":[116],"genes":[118,141,152],"implicated":[119],"directly":[120],"or":[121],"indirectly":[122],"cytoskeletal":[124,215],"dysregulation":[125],"tissues":[128],"saline-treated":[130],"versus":[131],"rats.":[133],"Our":[134],"data":[135],"suggest":[136],"number":[139],"known":[142],"affect":[144],"tumorigenesis":[146],"up-regulated":[148],"colonocytes,":[150,165],"tumor":[157],"suppressors":[158],"metastatic":[160],"cancer":[161,249],"down-regulated":[163],"despite":[166],"colonocytes":[168],"being":[169],"histologically":[170],"normal.":[171],"further":[173],"understand":[174],"role":[176],"cytoskeleton":[179],"generating":[181],"cells,":[187],"pharmacological":[190],"disruption":[191],"(using":[192],"colchicine)":[193],"cytoskeleton.":[196],"found":[198],"differences":[200],"(between":[204],"AOM-":[205],"control-treated":[207],"rats)":[208],"were":[209],"negated":[210],"by":[211],"disruption,":[213],"suggesting":[214],"involvement":[216],"changes.":[220],"These":[221],"studies":[222],"provide":[223],"significant":[224],"insights":[225],"into":[226],"micro-architectural":[228],"carcinogenesis,":[233],"may":[235],"enable":[236],"optimization":[237],"both":[239],"bio-photonic":[240],"risk":[243],"stratification":[244],"techniques":[245],"personalize":[247],"screening.":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
