{"id":"https://openalex.org/W1978644911","doi":"https://doi.org/10.1249/01.mss.0000321495.45721.88","title":"Relationship Between Physical Activity and Vascular Function: Adolescent Obesity and Type 2 Diabetes","display_name":"Relationship Between Physical Activity and Vascular Function: Adolescent Obesity and Type 2 Diabetes","publication_year":2008,"publication_date":"2008-05-01","ids":{"openalex":"https://openalex.org/W1978644911","doi":"https://doi.org/10.1249/01.mss.0000321495.45721.88","mag":"1978644911"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000321495.45721.88","doi":"https://doi.org/10.1249/01.mss.0000321495.45721.88","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000321495.45721.88","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112369551","display_name":"Randal P. Claytor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Randal P. Claytor","raw_affiliation_strings":["Maimi University and CCHMC, Oxford, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maimi University and CCHMC, Oxford, OH","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049330077","display_name":"Elaine M. Urbina","orcid":"https://orcid.org/0000-0002-5640-6777","observed_orcids":["https://orcid.org/0000-0002-5640-6777"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine M. Urbina","raw_affiliation_strings":["CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108725017","display_name":"Phillip R. Khoury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip R. Khoury","raw_affiliation_strings":["CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052455098","display_name":"Lawrence M. Dolan","orcid":"https://orcid.org/0000-0002-5359-0636","observed_orcids":["https://orcid.org/0000-0002-5359-0636"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence M. Dolan","raw_affiliation_strings":["CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062687198","display_name":"Stephen R. Daniels","orcid":"https://orcid.org/0000-0001-5520-6952","observed_orcids":["https://orcid.org/0000-0001-5520-6952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen R. Daniels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103221832","display_name":"Thomas R. Kimball","orcid":"https://orcid.org/0000-0001-5428-4182","observed_orcids":["https://orcid.org/0000-0001-5428-4182","https://orcid.org/0000-0003-3283-2381"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Kimball","raw_affiliation_strings":["CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCHMC & University of Cincinnati, Cincinnati, OH. 3Colorado Health Sciences Center, Denver, CO. (Sponsor: Jeffrey Potteiger, FACSM)","institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13224158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"5","first_page":"S12","last_page":"S12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10352","display_name":"Physical Activity and Health","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vascular-function","display_name":"vascular function","score":0.8009999990463257},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.9330000281333923},{"id":"https://openalex.org/keywords/pulse-wave-velocity","display_name":"pulse wave velocity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/adolescent-obesity","display_name":"adolescent obesity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.828000009059906},{"id":"https://openalex.org/keywords/accelerometry","display_name":"accelerometry","score":0.7110000252723694},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.6600000262260437},{"id":"https://openalex.org/keywords/race","display_name":"race","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8732912540435791},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.845637321472168},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.7616958618164062},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.6929671764373779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.67294842004776},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.6032986044883728},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5878381729125977},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4972579777240753},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4824807941913605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4560333490371704},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.44339847564697266},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2758309543132782}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000321495.45721.88","doi":"https://doi.org/10.1249/01.mss.0000321495.45721.88","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000321495.45721.88","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033732221","https://openalex.org/W1999200826","https://openalex.org/W2005371675","https://openalex.org/W1820521350","https://openalex.org/W7204207743","https://openalex.org/W2917107616","https://openalex.org/W2107209567","https://openalex.org/W2805853835","https://openalex.org/W2901728324","https://openalex.org/W2015454098"],"abstract_inverted_index":{"PURPOSE:":[0],"Childhood":[1],"overweight":[2],"and":[3,18,37,59,70,103,146,177,196,260,278],"obesity":[4,58,277],"have":[5],"nearly":[6],"tripled":[7],"over":[8],"the":[9,71,79,86,89,193,207],"last":[10],"30":[11],"years,":[12],"likely":[13],"related":[14],"to":[15,43,54,84,172,223,225,283,289],"poor":[16],"diet":[17],"decreased":[19],"physical":[20,285],"activity":[21,286],"(PA).":[22],"Several":[23],"reports":[24],"suggest":[25],"that":[26,241],"as":[27],"a":[28,92,110,216,244],"result":[29],"of":[30,73,88,95,107,113,181,210,249],"this":[31],"phenomenon,":[32],"cardiovascular":[33],"(CV)":[34],"risk":[35],"factors":[36,254],"CV":[38,147,293],"diseases":[39,294],"(CVD)":[40],"are":[41,116,255,287],"beginning":[42],"present":[44],"at":[45],"much":[46],"earlier":[47],"ages.":[48],"Arterial":[49],"stiffness":[50,273],"has":[51],"been":[52],"shown":[53],"be":[55],"associated":[56,269],"with":[57,125,235,270,276],"CVD":[60],"in":[61,75,109,219,274,295],"adults,":[62],"however":[63],"very":[64],"little":[65],"information":[66],"exists":[67],"regarding":[68],"adolescents":[69,114,275],"role":[72],"PA":[74,108,149,209,236,242,267],"vascular":[76,182],"function.":[77],"Therefore,":[78],"T2CVD":[80],"study":[81],"was":[82,150,161,215,232,243],"designed":[83],"determine":[85],"extent":[87],"relationship":[90],"between":[91],"non-invasive":[93],"measure":[94,106],"arterial":[96,164,250,272],"stiffness,":[97],"aorto-femoral":[98],"pulse":[99],"wave":[100],"velocity":[101],"(PWV),":[102],"an":[104],"objective":[105],"large":[111],"sample":[112],"who":[115],"either":[117],"normal":[118],"weight":[119],"(N),":[120],"obese":[121,124],"(O),":[122],"or":[123],"Type":[126],"2":[127,280],"diabetes":[128],"mellitus":[129],"(T).":[130],"METHODS:":[131],"258":[132],"subjects":[133],"(age":[134],"14-23":[135],"yrs)":[136],"39%":[137],"male,":[138],"65%":[139],"non-Caucasian":[140],"underwent":[141],"anthropometric,":[142],"dietary,":[143],"PA,":[144],"metabolic,":[145],"evaluation.":[148],"assessed":[151],"by":[152,189],"accelerometry":[153],"(7":[154],"consecutive":[155],"days":[156],"during":[157],"awake":[158],"hours).":[159],"PWV":[160,220,231],"measured":[162],"using":[163],"tonometery.":[165],"General":[166],"Linear":[167],"Models":[168],"analyses":[169],"were":[170],"performed":[171],"evaluate":[173],"group":[174,258],"mean":[175],"differences":[176],"elucidate":[178],"independent":[179,246],"determinants":[180],"outcomes.":[183],"RESULTS:":[184],"Groups":[185],"did":[186],"not":[187],"differ":[188],"age.":[190],"T":[191,199,226],"had":[192,200,206],"highest":[194],"glucose":[195],"O":[197,205,224],"&":[198],"higher":[201],"insulin":[202],"than":[203],"N.":[204],"lowest":[208],"all":[211],"3":[212],"groups.":[213],"There":[214],"graded":[217],"increase":[218,284],"from":[221],"N":[222],"(p<.0001)":[227],"indicating":[228],"increased":[229,271],"stiffness.":[230],"negatively":[233],"correlated":[234],"(p<0.0002).":[237],"Multivariate":[238],"models":[239],"demonstrated":[240],"significant":[245],"negative":[247],"determinate":[248],"stiffness;":[251],"other":[252],"contributing":[253],"BMI":[256],"Z-score,":[257],"(N,O,T),":[259],"race":[261],"(R2":[262],"=0.33,":[263],"p<0.001).":[264],"CONCLUSIONS:":[265],"Decreased":[266],"is":[268],"type":[279],"diabetes.":[281],"Interventions":[282],"needed":[288],"prevent":[290],"early":[291],"onset":[292],"youth.":[296]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}