{"id":"https://openalex.org/W1978641348","doi":"https://doi.org/10.1097/00004647-199701000-00009","title":"A Model for the Coupling between Cerebral Blood Flow and Oxygen Metabolism during Neural Stimulation","display_name":"A Model for the Coupling between Cerebral Blood Flow and Oxygen Metabolism during Neural Stimulation","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W1978641348","doi":"https://doi.org/10.1097/00004647-199701000-00009","mag":"1978641348","pmid":"https://pubmed.ncbi.nlm.nih.gov/8978388"},"language":"en","primary_location":{"id":"doi:10.1097/00004647-199701000-00009","doi":"https://doi.org/10.1097/00004647-199701000-00009","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00004647-199701000-00009","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-199701000-00009","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978641348"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-199701000-00009","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041500174","display_name":"Richard B. Buxton","orcid":"https://orcid.org/0000-0002-8819-1256","observed_orcids":["https://orcid.org/0000-0002-8819-1256"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B. Buxton","raw_affiliation_strings":["Department of Radiology, University of California at San Diego, San Diego, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of California at San Diego, San Diego, California, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090363793","display_name":"Lawrence R. Frank","orcid":"https://orcid.org/0000-0001-7235-587X","observed_orcids":["https://orcid.org/0000-0001-7235-587X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence R. Frank","raw_affiliation_strings":["Department of Radiology, University of California at San Diego, San Diego, California, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University of California at San Diego, San Diego, California, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":7.8252,"has_fulltext":true,"cited_by_count":823,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"1","first_page":"64","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.06610000133514404,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cerebral-metabolic-rate-for-oxygen","display_name":"cerebral oxygen consumption","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tight-coupling","display_name":"tight coupling","score":0.5879999995231628},{"id":"https://openalex.org/keywords/neurostimulation","display_name":"neurostimulation","score":0.871999979019165},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.6129999756813049},{"id":"https://openalex.org/keywords/capillary-perfusion","display_name":"capillary perfusion","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oxygen-extraction","display_name":"oxygen extraction","score":0.6190000176429749},{"id":"https://openalex.org/keywords/fmri","display_name":"functional MRI","score":0.6620000004768372},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"positron emission tomography","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.8207176923751831},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.72191321849823},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.611440896987915},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4955548048019409},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4925006330013275},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.4893757700920105},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48542436957359314},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4630906879901886},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.40516555309295654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39000290632247925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28549569845199585},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.27307242155075073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23515984416007996},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22305694222450256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1817067563533783},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.07863998413085938},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004647-199701000-00009","doi":"https://doi.org/10.1097/00004647-199701000-00009","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00004647-199701000-00009","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-199701000-00009","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:8978388","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8978388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/00004647-199701000-00009","doi":"https://doi.org/10.1097/00004647-199701000-00009","is_oa":true,"landing_page_url":"https://doi.org/10.1097/00004647-199701000-00009","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1097/00004647-199701000-00009","source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978641348.pdf","grobid_xml":"https://content.openalex.org/works/W1978641348.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W16603568","https://openalex.org/W150101672","https://openalex.org/W153457491","https://openalex.org/W161661889","https://openalex.org/W267275744","https://openalex.org/W1574637310","https://openalex.org/W1904256546","https://openalex.org/W1944705852","https://openalex.org/W1964906439","https://openalex.org/W1965253632","https://openalex.org/W1967009686","https://openalex.org/W1978262170","https://openalex.org/W1985500693","https://openalex.org/W1993303421","https://openalex.org/W1997161516","https://openalex.org/W2002389309","https://openalex.org/W2002660165","https://openalex.org/W2007384220","https://openalex.org/W2007797171","https://openalex.org/W2009570510","https://openalex.org/W2010769464","https://openalex.org/W2011221428","https://openalex.org/W2014875176","https://openalex.org/W2030431065","https://openalex.org/W2037926997","https://openalex.org/W2037945327","https://openalex.org/W2050135403","https://openalex.org/W2050717100","https://openalex.org/W2052460689","https://openalex.org/W2058012218","https://openalex.org/W2060292278","https://openalex.org/W2063647875","https://openalex.org/W2071246442","https://openalex.org/W2076117403","https://openalex.org/W2088362453","https://openalex.org/W2088774650","https://openalex.org/W2090198804","https://openalex.org/W2092414841","https://openalex.org/W2110986377","https://openalex.org/W2124913096","https://openalex.org/W2135045015","https://openalex.org/W2153726810","https://openalex.org/W2170117095","https://openalex.org/W2171263166","https://openalex.org/W2199796131","https://openalex.org/W2234547199","https://openalex.org/W2263620930","https://openalex.org/W2287029021","https://openalex.org/W2300098041","https://openalex.org/W2322678080"],"related_works":["https://openalex.org/W2032979674","https://openalex.org/W2099802623","https://openalex.org/W2134922993","https://openalex.org/W2048705910","https://openalex.org/W1990642581","https://openalex.org/W2018108370","https://openalex.org/W1988794652","https://openalex.org/W2018431813","https://openalex.org/W99098","https://openalex.org/W7048815832"],"abstract_inverted_index":{"A":[0],"general":[1],"mathematical":[2],"model":[3,41,107],"for":[4,111],"the":[5,10,16,21,32,36,59,76,92,112],"delivery":[6],"of":[7,20,31,66,75,101,115,124],"O2":[8,60],"to":[9,54],"brain":[11,22,78],"is":[12,38],"presented,":[13],"based":[14],"on":[15],"assumptions":[17],"that":[18,29,43,83],"all":[19,30],"capillaries":[23,37],"are":[24,50,96],"perfused":[25],"at":[26],"rest":[27],"and":[28,103],"oxygen":[33,93],"extracted":[34],"from":[35],"metabolized.":[39],"The":[40,106],"predicts":[42],"disproportionately":[44],"large":[45],"changes":[46,57,125],"in":[47,52,58,64,122,126],"blood":[48,85],"flow":[49,86,102],"required":[51],"order":[53],"support":[55],"small":[56],"metabolic":[61,94],"rate.":[62],"Interpreted":[63],"terms":[65,123],"this":[67],"model,":[68],"previous":[69],"positron":[70],"emission":[71],"tomography":[72],"(PET)":[73],"studies":[74,121],"human":[77],"during":[79],"neural":[80],"stimulation":[81],"demonstrating":[82],"cerebral":[84],"(CBF)":[87],"increases":[88],"much":[89],"more":[90],"than":[91],"rate":[95],"consistent":[97],"with":[98],"tight":[99],"coupling":[100],"oxidative":[104],"metabolism.":[105],"provides":[108],"a":[109],"basis":[110],"quantitative":[113],"interpretation":[114],"functional":[116],"magnetic":[117],"resonance":[118],"imaging":[119],"(fMRI)":[120],"local":[127],"CBF.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":28},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":41},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":30}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
