{"id":"https://openalex.org/W1978629545","doi":"https://doi.org/10.1371/journal.pone.0017850","title":"Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer","display_name":"Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer","publication_year":2011,"publication_date":"2011-03-09","ids":{"openalex":"https://openalex.org/W1978629545","doi":"https://doi.org/10.1371/journal.pone.0017850","mag":"1978629545","pmid":"https://pubmed.ncbi.nlm.nih.gov/21408027","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3052388"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0017850","doi":"https://doi.org/10.1371/journal.pone.0017850","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0017850","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017850&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017850&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101427104","display_name":"Bin Bao","orcid":"https://orcid.org/0000-0001-9312-5096","observed_orcids":["https://orcid.org/0000-0001-9312-5096"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Bao","raw_affiliation_strings":["Department of Pathology, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105402676","display_name":"Shadan S. Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shadan Ali","raw_affiliation_strings":["Division of Hematology/Oncology Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112111285","display_name":"Dejuan Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dejuan Kong","raw_affiliation_strings":["Department of Pathology, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060931275","display_name":"Sanila H. Sarkar","orcid":"https://orcid.org/0009-0007-4421-4915","observed_orcids":["https://orcid.org/0009-0007-4421-4915"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanila H. Sarkar","raw_affiliation_strings":["Department of Pathology, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108091820","display_name":"Zhiwei Wang","orcid":"https://orcid.org/0009-0000-2961-8304","observed_orcids":["https://orcid.org/0009-0000-2961-8304"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiwei Wang","raw_affiliation_strings":["Department of Pathology, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112013421","display_name":"Sanjeev Banerjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjeev Banerjee","raw_affiliation_strings":["Department of Pathology, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038465132","display_name":"Amro Aboukameel","orcid":"https://orcid.org/0009-0009-9912-2887","observed_orcids":["https://orcid.org/0009-0009-9912-2887"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amro Aboukameel","raw_affiliation_strings":["Division of Hematology/Oncology Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103248527","display_name":"Subhash Padhy\u00e9","orcid":"https://orcid.org/0000-0002-9401-2007","observed_orcids":["https://orcid.org/0000-0002-9401-2007"]},"institutions":[{"id":"https://openalex.org/I4210153931","display_name":"DY Patil Deemed to be University","ror":"https://ror.org/045qb5273","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210153931"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhash Padhye","raw_affiliation_strings":["Dr. D. Y. Patil University, Pimpri, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. D. Y. Patil University, Pimpri, Pune, India","institution_ids":["https://openalex.org/I4210153931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011817630","display_name":"Philip A. Philip","orcid":"https://orcid.org/0000-0002-6513-3491","observed_orcids":["https://orcid.org/0000-0002-6513-3491"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip A. Philip","raw_affiliation_strings":["Division of Hematology/Oncology Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109278193","display_name":"Fazlul H. Sarkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fazlul H. Sarkar","raw_affiliation_strings":["Department of Pathology, Wayne State University, Detroit, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Wayne State University, Detroit, Michigan, United States of America","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109278193"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":15.568,"has_fulltext":true,"cited_by_count":196,"citation_normalized_percentile":{"value":0.99557668,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"6","issue":"3","first_page":"e17850","last_page":"e17850"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.11659999936819077,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.05180000141263008,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mir-200-family","display_name":"miR-200 family","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":1.0},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9649999737739563},{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9440000057220459},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.6869999766349792},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7585065364837646},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7506684064865112},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.7061086893081665},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.682831346988678},{"id":"https://openalex.org/C2778987575","wikidata":"https://www.wikidata.org/wiki/Q21145992","display_name":"BMI1","level":3,"score":0.6525729298591614},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6328701972961426},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5259542465209961},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5191475749015808},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.49090129137039185},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46441954374313354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3752050995826721},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36967456340789795},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3483012914657593},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3053533434867859},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22081536054611206},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.15644201636314392},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11501350998878479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08271333575248718}],"mesh":[{"descriptor_ui":"D000071858","descriptor_name":"Epithelial Cell Adhesion Molecule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0017850","doi":"https://doi.org/10.1371/journal.pone.0017850","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0017850","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017850&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3052388","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3052388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21408027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21408027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.293.4554","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.4554","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2a/e1/PLoS_One_2011_Mar_9_6(3)_e17850.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:3c20e081674749c5826e099864e53f8d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c20e081674749c5826e099864e53f8d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 3, p e17850 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0017850","doi":"https://doi.org/10.1371/journal.pone.0017850","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0017850","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017850&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5259760061","display_name":"RO1: A novel and targeted approach to inhibit invasion and angiogenesis","funder_award_id":"R01CA131151","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8074806580","display_name":"FoxM1: A molecular target in pancreatic cancer","funder_award_id":"R01CA132794","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8579852739","display_name":"Prevention of Tumor Progression by a Novel Approach","funder_award_id":"R01CA154321","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978629545.pdf","grobid_xml":"https://content.openalex.org/works/W1978629545.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W95463455","https://openalex.org/W1573024086","https://openalex.org/W1968406486","https://openalex.org/W1980920427","https://openalex.org/W1991956628","https://openalex.org/W1994924002","https://openalex.org/W1997149430","https://openalex.org/W1997486699","https://openalex.org/W1999360191","https://openalex.org/W2000093333","https://openalex.org/W2000378868","https://openalex.org/W2000932071","https://openalex.org/W2007286418","https://openalex.org/W2009826571","https://openalex.org/W2014128254","https://openalex.org/W2014442719","https://openalex.org/W2017905687","https://openalex.org/W2020695289","https://openalex.org/W2033681249","https://openalex.org/W2035987476","https://openalex.org/W2050732573","https://openalex.org/W2056953440","https://openalex.org/W2059022111","https://openalex.org/W2077365696","https://openalex.org/W2077945404","https://openalex.org/W2078882223","https://openalex.org/W2080724286","https://openalex.org/W2082481019","https://openalex.org/W2101995865","https://openalex.org/W2104610341","https://openalex.org/W2126793001","https://openalex.org/W2142801414","https://openalex.org/W2185138096","https://openalex.org/W2234196245"],"related_works":["https://openalex.org/W1964969489","https://openalex.org/W1586400045","https://openalex.org/W2152561870","https://openalex.org/W2566115634","https://openalex.org/W2051417597","https://openalex.org/W1999941999","https://openalex.org/W2318630559","https://openalex.org/W2146016283","https://openalex.org/W2123451868","https://openalex.org/W4210513049"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"existence":[2],"of":[3,25,35,45,83,114,121,128,143,157,197,203,208,220,225],"cancer":[4,9,90],"stem":[5],"cells":[6,11,116,139],"(CSCs)":[7],"or":[8],"stem-like":[10],"in":[12,64,88,135,185,231],"a":[13,39,56,153],"tumor":[14,22,46,164,186,221],"mass":[15],"is":[16,199],"believed":[17],"to":[18],"be":[19,38,215],"responsible":[20],"for":[21,42,101,217],"recurrence":[23,47,222],"because":[24],"their":[26],"intrinsic":[27],"and":[28,70,76,86,132,149,176,179,182],"extrinsic":[29],"drug-resistance":[30],"characteristics.":[31],"Therefore,":[32,212],"targeted":[33],"killing":[34],"CSCs":[36,144],"would":[37],"newer":[40],"strategy":[41],"the":[43,96,102,110,194,218,232],"prevention":[44,219],"and/or":[48,223],"treatment":[49,161,224,229],"by":[50,81],"overcoming":[51],"drug-resistance.":[52],"We":[53],"have":[54],"developed":[55],"novel":[57],"synthetic":[58],"compound-CDF,":[59],"which":[60,78,123,166],"showed":[61],"greater":[62],"bioavailability":[63],"animal":[65],"tissues":[66],"such":[67],"as":[68],"pancreas,":[69],"also":[71],"induced":[72],"cell":[73],"growth":[74],"inhibition":[75,202],"apoptosis,":[77],"was":[79,124,167],"mediated":[80],"inactivation":[82],"NF-\u03baB,":[84],"COX-2,":[85,175],"VEGF":[87],"pancreatic":[89],"(PC)":[91],"cells.":[92],"METHODOLOGY/PRINCIPAL":[93],"FINDINGS:":[94],"In":[95,152],"current":[97],"study":[98],"we":[99],"showed,":[100],"first":[103],"time,":[104],"that":[105,193],"CDF":[106,160,198,213],"could":[107,214],"significantly":[108,162],"inhibit":[109],"sphere-forming":[111],"ability":[112],"(pancreatospheres)":[113],"PC":[115,138,226],"consistent":[117,145],"with":[118,126,146,169,201,227],"increased":[119,147,180],"disintegration":[120],"pancreatospheres,":[122],"associated":[125,168,200],"attenuation":[127],"CSC":[129,204],"markers":[130],"(CD44":[131],"EpCAM),":[133],"especially":[134],"gemcitabine-resistant":[136],"(MIAPaCa-2)":[137],"containing":[140],"high":[141],"proportion":[142],"miR-21":[148,177],"decreased":[150,170],"miR-200.":[151],"xenograft":[154],"mouse":[155],"model":[156],"human":[158],"PC,":[159],"inhibited":[163],"growth,":[165],"NF-\u03baB":[171],"DNA":[172],"binding":[173],"activity,":[174],"expression,":[178],"PTEN":[181],"miR-200":[183],"expression":[184],"remnants.":[187],"CONCLUSIONS/SIGNIFICANCE:":[188],"These":[189],"results":[190],"strongly":[191],"suggest":[192],"anti-tumor":[195],"activity":[196],"function":[205],"via":[206],"down-regulation":[207],"CSC-associated":[209],"signaling":[210],"pathways.":[211],"useful":[216],"better":[228],"outcome":[230],"future.":[233]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":31}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}