{"id":"https://openalex.org/W1978627274","doi":"https://doi.org/10.1016/0022-2836(73)90170-8","title":"Regulation of protein synthesis in mammalian cells","display_name":"Regulation of protein synthesis in mammalian cells","publication_year":1973,"publication_date":"1973-10-01","ids":{"openalex":"https://openalex.org/W1978627274","doi":"https://doi.org/10.1016/0022-2836(73)90170-8","mag":"1978627274","pmid":"https://pubmed.ncbi.nlm.nih.gov/4763984"},"language":"en","primary_location":{"id":"doi:10.1016/0022-2836(73)90170-8","doi":"https://doi.org/10.1016/0022-2836(73)90170-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(73)90170-8","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110108734","display_name":"E.S. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.S. Goldstein","raw_affiliation_strings":["Department of Biology, 16-839, Massachusetts Institute of Technology, Cambridge, Mass. 02139 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, 16-839, Massachusetts Institute of Technology, Cambridge, Mass. 02139 U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110114490","display_name":"Sheldon Penman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Penman","raw_affiliation_strings":["Department of Biology, 16-839, Massachusetts Institute of Technology, Cambridge, Mass. 02139 U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, 16-839, Massachusetts Institute of Technology, Cambridge, Mass. 02139 U.S.A","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":6.9847,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.98141885,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"80","issue":"2","first_page":"243","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-synthesis-regulation","display_name":"protein synthesis regulation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/actinomycin","display_name":"actinomycin","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.5960000157356262},{"id":"https://openalex.org/keywords/polysomes","display_name":"polysomes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.5170000195503235},{"id":"https://openalex.org/keywords/translation-rate","display_name":"translation rate","score":0.3869999945163727},{"id":"https://openalex.org/keywords/rna-synthesis","display_name":"RNA synthesis","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.8875924348831177},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.8674147129058838},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.7732628583908081},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7059499621391296},{"id":"https://openalex.org/C65666806","wikidata":"https://www.wikidata.org/wiki/Q970614","display_name":"Polysome","level":5,"score":0.7032488584518433},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5756122469902039},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5627341270446777},{"id":"https://openalex.org/C2776695378","wikidata":"https://www.wikidata.org/wiki/Q186127","display_name":"Dactinomycin","level":4,"score":0.558599054813385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.544999361038208},{"id":"https://openalex.org/C2779200571","wikidata":"https://www.wikidata.org/wiki/Q424696","display_name":"Puromycin","level":3,"score":0.4804374873638153},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4730093777179718},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4250532388687134},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.42057403922080994},{"id":"https://openalex.org/C2781363766","wikidata":"https://www.wikidata.org/wiki/Q7251505","display_name":"Protein synthesis inhibitor","level":4,"score":0.41878071427345276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37087804079055786},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33631211519241333},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26411789655685425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08365726470947266}],"mesh":[{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-2836(73)90170-8","doi":"https://doi.org/10.1016/0022-2836(73)90170-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-2836(73)90170-8","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:4763984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4763984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1529401899","https://openalex.org/W1544896193","https://openalex.org/W1546862442","https://openalex.org/W1592629267","https://openalex.org/W1996404286","https://openalex.org/W2013141442","https://openalex.org/W2013651327","https://openalex.org/W2016407154","https://openalex.org/W2017312207","https://openalex.org/W2020977398","https://openalex.org/W2023986404","https://openalex.org/W2032953859","https://openalex.org/W2038019779","https://openalex.org/W2053654911","https://openalex.org/W2067606331","https://openalex.org/W2073250430","https://openalex.org/W2076936056","https://openalex.org/W2117348012","https://openalex.org/W2127385301","https://openalex.org/W2156506178"],"related_works":["https://openalex.org/W2081644026","https://openalex.org/W2076936056","https://openalex.org/W2013141442","https://openalex.org/W2065829966","https://openalex.org/W2012448350","https://openalex.org/W2098840785","https://openalex.org/W1964076323","https://openalex.org/W2136852926","https://openalex.org/W2013835032","https://openalex.org/W2441632326"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}