{"id":"https://openalex.org/W1978623496","doi":"https://doi.org/10.1038/nrn3526","title":"The histaminergic network in the brain: basic organization and role in disease","display_name":"The histaminergic network in the brain: basic organization and role in disease","publication_year":2013,"publication_date":"2013-06-20","ids":{"openalex":"https://openalex.org/W1978623496","doi":"https://doi.org/10.1038/nrn3526","mag":"1978623496","pmid":"https://pubmed.ncbi.nlm.nih.gov/23783198"},"language":"en","primary_location":{"id":"doi:10.1038/nrn3526","doi":"https://doi.org/10.1038/nrn3526","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn3526","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978623496"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014800650","display_name":"Pertti Panula","orcid":"https://orcid.org/0000-0002-1189-5132","observed_orcids":["https://orcid.org/0000-0002-1189-5132"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Pertti Panula","raw_affiliation_strings":["Neuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland. pertti.panula@ helsinki.fi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland. pertti.panula@ helsinki.fi","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013795857","display_name":"Saara Nuutinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Saara Nuutinen","raw_affiliation_strings":["Neuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland","Neuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Neuroscience Center and Institute of Biomedicine, Anatomy, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014800650"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":null,"apc_paid":null,"fwci":2.149,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.890681,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":"7","first_page":"472","last_page":"487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.4887999892234802,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.4887999892234802,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.22390000522136688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.21170000731945038,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.8830000162124634},{"id":"https://openalex.org/keywords/histaminergic-system","display_name":"histaminergic system","score":0.9810000061988831},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/wakefulness","display_name":"wakefulness","score":0.9120000004768372},{"id":"https://openalex.org/keywords/sleep-regulation","display_name":"sleep regulation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/narcolepsy","display_name":"narcolepsy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/addiction","display_name":"addiction","score":0.7419999837875366},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalitis","display_name":"experimental autoimmune encephalitis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/brain-disorders","display_name":"brain disorders","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2778501154","wikidata":"https://www.wikidata.org/wiki/Q18349602","display_name":"Histaminergic","level":3,"score":0.9707249999046326},{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.7591565251350403},{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.739206075668335},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7370579838752747},{"id":"https://openalex.org/C3017459112","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter systems","level":3,"score":0.5775290727615356},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5622924566268921},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47441571950912476},{"id":"https://openalex.org/C63180777","wikidata":"https://www.wikidata.org/wiki/Q288395","display_name":"Histamine H3 receptor","level":4,"score":0.47019633650779724},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41792720556259155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37128913402557373},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.23070764541625977},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.16194528341293335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15712270140647888},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14290174841880798},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.13482972979545593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12748852372169495},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.08353850245475769}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrn3526","doi":"https://doi.org/10.1038/nrn3526","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrn3526","pdf_url":null,"source":{"id":"https://openalex.org/S26843219","display_name":"Nature reviews. Neuroscience","issn_l":"1471-003X","issn":["1471-003X","1471-0048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Neuroscience","raw_type":"journal-article"},{"id":"pmid:23783198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23783198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311816","display_name":"Finska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/04vbzm272"},{"id":"https://openalex.org/F4320322400","display_name":"Magnus Ehrnroothin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/02cdzet69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":203,"referenced_works":["https://openalex.org/W56230035","https://openalex.org/W74595266","https://openalex.org/W616793708","https://openalex.org/W1485120860","https://openalex.org/W1493410983","https://openalex.org/W1519232679","https://openalex.org/W1524949005","https://openalex.org/W1533063439","https://openalex.org/W1556108117","https://openalex.org/W1562877317","https://openalex.org/W1565956084","https://openalex.org/W1573714023","https://openalex.org/W1578148915","https://openalex.org/W1627229807","https://openalex.org/W1637971961","https://openalex.org/W1658437126","https://openalex.org/W1836788078","https://openalex.org/W1838211711","https://openalex.org/W1878860530","https://openalex.org/W1917933986","https://openalex.org/W1952041769","https://openalex.org/W1963562725","https://openalex.org/W1964722535","https://openalex.org/W1964922357","https://openalex.org/W1967237555","https://openalex.org/W1967643491","https://openalex.org/W1968695161","https://openalex.org/W1968995022","https://openalex.org/W1969766828","https://openalex.org/W1972840565","https://openalex.org/W1974112812","https://openalex.org/W1974929497","https://openalex.org/W1979561342","https://openalex.org/W1980043169","https://openalex.org/W1981021367","https://openalex.org/W1981298128","https://openalex.org/W1981929421","https://openalex.org/W1984308291","https://openalex.org/W1988514864","https://openalex.org/W1989459627","https://openalex.org/W1989531381","https://openalex.org/W1990593389","https://openalex.org/W1990809315","https://openalex.org/W1991641789","https://openalex.org/W1993640624","https://openalex.org/W1995291346","https://openalex.org/W1996285538","https://openalex.org/W1996713062","https://openalex.org/W1996815356","https://openalex.org/W1998618539","https://openalex.org/W1999919528","https://openalex.org/W2000004939","https://openalex.org/W2000367437","https://openalex.org/W2000524884","https://openalex.org/W2001495408","https://openalex.org/W2002293846","https://openalex.org/W2002990363","https://openalex.org/W2003967044","https://openalex.org/W2004778369","https://openalex.org/W2005006086","https://openalex.org/W2005340559","https://openalex.org/W2006610796","https://openalex.org/W2006990513","https://openalex.org/W2008663019","https://openalex.org/W2009189044","https://openalex.org/W2011592796","https://openalex.org/W2012067617","https://openalex.org/W2012660986","https://openalex.org/W2012953094","https://openalex.org/W2016603747","https://openalex.org/W2017608248","https://openalex.org/W2018637061","https://openalex.org/W2019926860","https://openalex.org/W2020067257","https://openalex.org/W2020433416","https://openalex.org/W2021876207","https://openalex.org/W2022628868","https://openalex.org/W2026501736","https://openalex.org/W2027740042","https://openalex.org/W2028052082","https://openalex.org/W2028254957","https://openalex.org/W2028413095","https://openalex.org/W2029578168","https://openalex.org/W2032530293","https://openalex.org/W2033124222","https://openalex.org/W2034366766","https://openalex.org/W2035744265","https://openalex.org/W2037700624","https://openalex.org/W2038749612","https://openalex.org/W2039031830","https://openalex.org/W2039954853","https://openalex.org/W2040080531","https://openalex.org/W2041495185","https://openalex.org/W2042040860","https://openalex.org/W2042252144","https://openalex.org/W2042513904","https://openalex.org/W2043082224","https://openalex.org/W2043551756","https://openalex.org/W2044927120","https://openalex.org/W2047066043","https://openalex.org/W2047464126","https://openalex.org/W2048292780","https://openalex.org/W2049565893","https://openalex.org/W2050074228","https://openalex.org/W2051349792","https://openalex.org/W2052032833","https://openalex.org/W2053894101","https://openalex.org/W2055634052","https://openalex.org/W2055718975","https://openalex.org/W2057132663","https://openalex.org/W2058159881","https://openalex.org/W2058601313","https://openalex.org/W2059148567","https://openalex.org/W2059359671","https://openalex.org/W2059581034","https://openalex.org/W2059784266","https://openalex.org/W2061112647","https://openalex.org/W2061409645","https://openalex.org/W2061420115","https://openalex.org/W2061950086","https://openalex.org/W2062320582","https://openalex.org/W2064144048","https://openalex.org/W2064457465","https://openalex.org/W2065515749","https://openalex.org/W2066607702","https://openalex.org/W2066645424","https://openalex.org/W2066997099","https://openalex.org/W2068401192","https://openalex.org/W2069779039","https://openalex.org/W2072214837","https://openalex.org/W2074292769","https://openalex.org/W2074490180","https://openalex.org/W2074926332","https://openalex.org/W2075212681","https://openalex.org/W2077687762","https://openalex.org/W2079148313","https://openalex.org/W2080186455","https://openalex.org/W2082141579","https://openalex.org/W2082258956","https://openalex.org/W2083551870","https://openalex.org/W2083838738","https://openalex.org/W2085372550","https://openalex.org/W2085497461","https://openalex.org/W2085902329","https://openalex.org/W2086725596","https://openalex.org/W2087024027","https://openalex.org/W2088754053","https://openalex.org/W2090156875","https://openalex.org/W2092542705","https://openalex.org/W2092781217","https://openalex.org/W2093069882","https://openalex.org/W2094257584","https://openalex.org/W2094414127","https://openalex.org/W2095559540","https://openalex.org/W2096209642","https://openalex.org/W2098258490","https://openalex.org/W2102729381","https://openalex.org/W2106581514","https://openalex.org/W2111189579","https://openalex.org/W2114204856","https://openalex.org/W2114265061","https://openalex.org/W2114701433","https://openalex.org/W2115951699","https://openalex.org/W2116540282","https://openalex.org/W2118388838","https://openalex.org/W2118821584","https://openalex.org/W2123035658","https://openalex.org/W2125727006","https://openalex.org/W2127182681","https://openalex.org/W2127339766","https://openalex.org/W2127398647","https://openalex.org/W2128273379","https://openalex.org/W2129535012","https://openalex.org/W2129701196","https://openalex.org/W2133162113","https://openalex.org/W2134850980","https://openalex.org/W2136371196","https://openalex.org/W2136860890","https://openalex.org/W2139322044","https://openalex.org/W2139736739","https://openalex.org/W2140122537","https://openalex.org/W2141634144","https://openalex.org/W2143698109","https://openalex.org/W2145322778","https://openalex.org/W2146643950","https://openalex.org/W2146999133","https://openalex.org/W2147320841","https://openalex.org/W2152211310","https://openalex.org/W2152253642","https://openalex.org/W2152452311","https://openalex.org/W2156078262","https://openalex.org/W2157558738","https://openalex.org/W2157954809","https://openalex.org/W2160692765","https://openalex.org/W2161847321","https://openalex.org/W2164701017","https://openalex.org/W2171629666","https://openalex.org/W2257594985","https://openalex.org/W2328151183","https://openalex.org/W2411479851","https://openalex.org/W2414818666","https://openalex.org/W2418508915","https://openalex.org/W7097312470"],"related_works":["https://openalex.org/W3199636261","https://openalex.org/W2018433476","https://openalex.org/W1945773664","https://openalex.org/W2041960301","https://openalex.org/W2123035658","https://openalex.org/W3047121165","https://openalex.org/W3179947249","https://openalex.org/W2036099970","https://openalex.org/W2891266274"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":30},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}