{"id":"https://openalex.org/W1978605356","doi":"https://doi.org/10.1152/ajprenal.00674.2014","title":"Impact of a folic acid-enriched diet on urinary tract function in mice treated with testosterone and estradiol","display_name":"Impact of a folic acid-enriched diet on urinary tract function in mice treated with testosterone and estradiol","publication_year":2015,"publication_date":"2015-04-08","ids":{"openalex":"https://openalex.org/W1978605356","doi":"https://doi.org/10.1152/ajprenal.00674.2014","mag":"1978605356","pmid":"https://pubmed.ncbi.nlm.nih.gov/25855514","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469891"},"language":"en","primary_location":{"id":"doi:10.1152/ajprenal.00674.2014","doi":"https://doi.org/10.1152/ajprenal.00674.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00674.2014","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469891","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052286925","display_name":"Kimberly P. Keil","orcid":"https://orcid.org/0000-0002-7006-9420","observed_orcids":["https://orcid.org/0000-0002-7006-9420"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly P. Keil","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090516237","display_name":"Lisa L. Abler","orcid":"https://orcid.org/0000-0001-9574-2741","observed_orcids":["https://orcid.org/0000-0001-9574-2741"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa L. Abler","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076116157","display_name":"Helene M. Altmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helene M. Altmann","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103124581","display_name":"Zunyi Wang","orcid":"https://orcid.org/0000-0002-1003-5456","observed_orcids":["https://orcid.org/0000-0002-1003-5456"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zunyi Wang","raw_affiliation_strings":["Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021921939","display_name":"Peiqing Wang","orcid":"https://orcid.org/0000-0002-4649-1875","observed_orcids":["https://orcid.org/0000-0002-4649-1875"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peiqing Wang","raw_affiliation_strings":["Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027205779","display_name":"William A. Ricke","orcid":"https://orcid.org/0000-0002-9807-2090","observed_orcids":["https://orcid.org/0000-0002-9807-2090"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Ricke","raw_affiliation_strings":["Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin; and","Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin;","George M. O'Brien Center of Benign Urology, University of Wisconsin-Madison, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin; and","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"George M. O'Brien Center of Benign Urology, University of Wisconsin-Madison, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082427145","display_name":"Dale E. Bjorling","orcid":"https://orcid.org/0000-0003-4680-7670","observed_orcids":["https://orcid.org/0000-0003-4680-7670"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale E. Bjorling","raw_affiliation_strings":["Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin;","Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin;","George M. O'Brien Center of Benign Urology, University of Wisconsin-Madison, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Urology, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"George M. O'Brien Center of Benign Urology, University of Wisconsin-Madison, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076908186","display_name":"Chad M. Vezina","orcid":"https://orcid.org/0000-0001-7058-5399","observed_orcids":["https://orcid.org/0000-0001-7058-5399"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chad M. Vezina","raw_affiliation_strings":["Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin; and","Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;","George M. O'Brien Center of Benign Urology, University of Wisconsin-Madison, Madison, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin; and","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin;","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"George M. O'Brien Center of Benign Urology, University of Wisconsin-Madison, Madison, Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076908186"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":null,"apc_paid":null,"fwci":2.5776,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.88049192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"308","issue":"12","first_page":"F1431","last_page":"F1443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lower-urinary-tract-dysfunction","display_name":"lower urinary tract dysfunction","score":0.824999988079071},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bladder-compliance","display_name":"bladder compliance","score":0.6129999756813049},{"id":"https://openalex.org/keywords/voiding-frequency","display_name":"voiding frequency","score":0.6029999852180481},{"id":"https://openalex.org/keywords/water-balance","display_name":"water balance","score":0.7179999947547913},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/micturition","display_name":"micturition","score":0.8420000076293945},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.7829999923706055},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.871999979019165},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.949999988079071},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/prostate","display_name":"prostate","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.672152042388916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6716257929801941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6611236333847046},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.623689591884613},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.5185297727584839},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5046216249465942},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.4502718150615692},{"id":"https://openalex.org/C175768497","wikidata":"https://www.wikidata.org/wiki/Q105726","display_name":"Urination","level":3,"score":0.4391520619392395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4211147129535675},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.4168870449066162},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3540284037590027},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.3356810510158539},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2851279377937317},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000821","descriptor_name":"Animal Feed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005727","descriptor_name":"Ganglia, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014553","descriptor_name":"Urinary Tract Physiological Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059411","descriptor_name":"Lower Urinary Tract Symptoms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajprenal.00674.2014","doi":"https://doi.org/10.1152/ajprenal.00674.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajprenal.00674.2014","pdf_url":null,"source":{"id":"https://openalex.org/S200780590","display_name":"American Journal of Physiology-Renal Physiology","issn_l":"1522-1466","issn":["1522-1466","1931-857X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Renal Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3871182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4469891","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469891","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Renal Physiol","raw_type":"Text"},{"id":"pmid:25855514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25855514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Renal physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3871182","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1632468835","display_name":null,"funder_award_id":"DK104310","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2241819658","display_name":"The Epigenome: A New Target for Androgen Receptor in Developing Prostate","funder_award_id":"R03DK096074","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G370101408","display_name":null,"funder_award_id":"DK096074","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4175232792","display_name":null,"funder_award_id":"DK099328","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5899162650","display_name":"Cellular and molecular mediators of fibrosis in the development of urinary tract dysfunction","funder_award_id":"U54DK104310","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6967373811","display_name":"Role of DNA methylation in prostate glandular development and urinary function","funder_award_id":"R01DK099328","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7338198309","display_name":null,"funder_award_id":"DH099328","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W198934061","https://openalex.org/W1490106730","https://openalex.org/W1497888373","https://openalex.org/W1537175468","https://openalex.org/W1568203056","https://openalex.org/W1941219655","https://openalex.org/W1964184380","https://openalex.org/W1967656765","https://openalex.org/W1975038057","https://openalex.org/W1979979997","https://openalex.org/W1992966506","https://openalex.org/W1994262469","https://openalex.org/W2005687876","https://openalex.org/W2010255118","https://openalex.org/W2011058607","https://openalex.org/W2023453643","https://openalex.org/W2038449831","https://openalex.org/W2039291409","https://openalex.org/W2042480238","https://openalex.org/W2051086099","https://openalex.org/W2066051248","https://openalex.org/W2068045945","https://openalex.org/W2075048079","https://openalex.org/W2082416575","https://openalex.org/W2083637504","https://openalex.org/W2086380718","https://openalex.org/W2087654797","https://openalex.org/W2105684645","https://openalex.org/W2105689564","https://openalex.org/W2107277218","https://openalex.org/W2111642061","https://openalex.org/W2117398145","https://openalex.org/W2131933136","https://openalex.org/W2139893960","https://openalex.org/W2152259313","https://openalex.org/W2167410483","https://openalex.org/W2294516516","https://openalex.org/W2335258962","https://openalex.org/W2396961956","https://openalex.org/W2587724197","https://openalex.org/W4290960820"],"related_works":["https://openalex.org/W2896820763","https://openalex.org/W2126234957","https://openalex.org/W2888049987","https://openalex.org/W1965033981","https://openalex.org/W1491996542","https://openalex.org/W2317606361","https://openalex.org/W2516464750","https://openalex.org/W7137269730","https://openalex.org/W2045651170","https://openalex.org/W4205251839"],"abstract_inverted_index":{"Aging":[0],"men":[1],"are":[2,218],"susceptible":[3],"to":[4,141,149,224],"developing":[5],"lower":[6],"urinary":[7,36,49,231],"tract":[8,37],"symptoms,":[9],"but":[10],"the":[11,17,158,199],"underlying":[12],"etiology":[13],"is":[14,26,117,191],"unknown":[15],"and":[16,21,39,45,55,76,79,153,172,181,208,211,213,239],"influence":[18],"of":[19,82,113,134,157,193],"dietary":[20],"environmental":[22],"factors":[23],"on":[24],"them":[25],"unclear.":[27],"We":[28,197],"tested":[29],"whether":[30],"a":[31,83,124,182],"folic":[32,84,125,137,183,221],"acid-enriched":[33,85,126,138,184],"diet":[34,86,185,201],"changed":[35],"physiology":[38],"biology":[40],"in":[41,63,121,147,170,206,230,233],"control":[42,133],"male":[43,46],"mice":[44,47],"with":[48,220],"dysfunction":[50],"induced":[51],"by":[52,123,235],"exogenous":[53],"testosterone":[54],"estradiol":[56],"(T+E2),":[57],"which":[58,116,190],"mimics":[59],"changing":[60],"hormone":[61],"levels":[62],"aging":[64],"humans.":[65],"T+E2":[66,108,179],"treatment":[67,109,180],"increased":[68,144,154,202],"mouse":[69],"urine":[70],"output,":[71],"time":[72],"between":[73],"voiding":[74,97,145],"events,":[75],"bladder":[77],"capacity":[78],"compliance.":[80],"Consumption":[81],"moderated":[87],"these":[88,103],"changes":[89,104],"without":[90],"decreasing":[91],"prostate":[92,210],"wet":[93],"weight":[94],"or":[95,226,241],"threshold":[96],"pressure.":[98],"One":[99],"potential":[100,129,164],"mechanism":[101,130],"for":[102],"involves":[105,131],"water":[106,237],"balance.":[107],"increases":[110],"plasma":[111],"concentrations":[112],"anti-diuretic":[114],"hormone,":[115],"offset":[118],"at":[119],"least":[120],"part":[122,234],"diet.":[127],"Another":[128],"neural":[132],"micturition.":[135],"The":[136],"diet,":[139],"fed":[140],"T+E2-treated":[142],"mice,":[143],"frequency":[146],"response":[148],"intravesicular":[150],"capsaicin":[151],"infusion":[152],"mRNA":[155],"abundance":[156],"capsaicin-sensitive":[159],"cation":[160],"channel":[161],"transient":[162],"receptor":[163],"vanilloid":[165],"subfamily":[166],"member":[167],"1":[168],"(Trpv1)":[169],"L6":[171,212],"S1":[173,214],"dorsal":[174,207],"root":[175],"ganglia":[176],"(DRG)":[177],"neurons.":[178],"also":[186],"modified":[187],"DNA":[188,204],"methylation,":[189],"capable":[192],"altering":[194],"gene":[195],"expression.":[196],"found":[198],"enriched":[200],"global":[203],"methylation":[205],"ventral":[209],"DRG.":[215],"Our":[216],"results":[217],"consistent":[219],"acid":[222],"acting":[223],"slow":[225],"reverse":[227],"T+E2-mediated":[228],"alteration":[229],"function":[232],"normalizing":[236],"balance":[238],"enhancing":[240],"preserving":[242],"afferent":[243],"neuronal":[244],"function.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}