{"id":"https://openalex.org/W1978595263","doi":"https://doi.org/10.1016/0005-2760(92)90203-8","title":"Inhibition of cellular transport systems by alkyl phospholipid analogs in HL-60 human leukemia cells","display_name":"Inhibition of cellular transport systems by alkyl phospholipid analogs in HL-60 human leukemia cells","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W1978595263","doi":"https://doi.org/10.1016/0005-2760(92)90203-8","mag":"1978595263","pmid":"https://pubmed.ncbi.nlm.nih.gov/1627636"},"language":"en","primary_location":{"id":"doi:10.1016/0005-2760(92)90203-8","doi":"https://doi.org/10.1016/0005-2760(92)90203-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2760(92)90203-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210194106","display_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","issn_l":"0005-2760","issn":["0005-2760","1879-145X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112496511","display_name":"Dennis R. Hoffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis R. Hoffman","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas","Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX - USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111822904","display_name":"Vickey L. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vickey L. Thomas","raw_affiliation_strings":["Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX USA","Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX - USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX - USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110459797","display_name":"Fred F. C. Snyder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281378812","display_name":"Oak Ridge Associated Universities","ror":"https://ror.org/0526p1y61","country_code":"US","type":"education","lineage":["https://openalex.org/I1281378812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fred Snyder","raw_affiliation_strings":["Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, TN USA","Medical and Health Sciences Division Oak Ridge Associated Universities, Oak Ridge, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, TN USA","institution_ids":["https://openalex.org/I1281378812"]},{"raw_affiliation_string":"Medical and Health Sciences Division Oak Ridge Associated Universities, Oak Ridge, TN, USA","institution_ids":["https://openalex.org/I1281378812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112496511"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":2.0978,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.87656904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1127","issue":"1","first_page":"74","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9309999942779541},{"id":"https://openalex.org/keywords/choline-transport","display_name":"choline transport","score":0.9869999885559082},{"id":"https://openalex.org/keywords/amino-acid-transport","display_name":"amino acid transport","score":0.8679999709129333},{"id":"https://openalex.org/keywords/fatty-acid-uptake","display_name":"fatty acid uptake","score":0.9919999837875366},{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.9430000185966492},{"id":"https://openalex.org/keywords/plasma-membrane-targeting","display_name":"plasma membrane targeting","score":0.4390000104904175},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.5070000290870667},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.7084076404571533},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.6381022334098816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6307546496391296},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.5927584171295166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5915594100952148},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48016658425331116},{"id":"https://openalex.org/C2776923060","wikidata":"https://www.wikidata.org/wiki/Q576895","display_name":"Phosphocholine","level":5,"score":0.4742514193058014},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45626094937324524},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4120527505874634},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3769686818122864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3712466061115265},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.25404873490333557},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.2431180477142334},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1927204728126526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009004","descriptor_name":"Monosaccharide Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010742","descriptor_name":"Phospholipid Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010742","descriptor_name":"Phospholipid Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010742","descriptor_name":"Phospholipid Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0005-2760(92)90203-8","doi":"https://doi.org/10.1016/0005-2760(92)90203-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0005-2760(92)90203-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210194106","display_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","issn_l":"0005-2760","issn":["0005-2760","1879-145X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism","raw_type":"journal-article"},{"id":"pmid:1627636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1627636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W130020229","https://openalex.org/W203563334","https://openalex.org/W1519229937","https://openalex.org/W1524769916","https://openalex.org/W1533708552","https://openalex.org/W1540191125","https://openalex.org/W1552240535","https://openalex.org/W1586496466","https://openalex.org/W1594758412","https://openalex.org/W1602053154","https://openalex.org/W1602490654","https://openalex.org/W1775749144","https://openalex.org/W1877848801","https://openalex.org/W1957284165","https://openalex.org/W1966129095","https://openalex.org/W1973625300","https://openalex.org/W1979447193","https://openalex.org/W2010057549","https://openalex.org/W2017092973","https://openalex.org/W2022771837","https://openalex.org/W2057912596","https://openalex.org/W2061415159","https://openalex.org/W2072097247","https://openalex.org/W2100462945","https://openalex.org/W2116275786","https://openalex.org/W2152311269","https://openalex.org/W2162756412","https://openalex.org/W2400968635","https://openalex.org/W2413849811","https://openalex.org/W2996686235","https://openalex.org/W4298344886","https://openalex.org/W7164808253"],"related_works":["https://openalex.org/W2022771837","https://openalex.org/W1980699306","https://openalex.org/W1528816585","https://openalex.org/W2153154277","https://openalex.org/W2400968635","https://openalex.org/W2017981328","https://openalex.org/W2406592367","https://openalex.org/W1602490654","https://openalex.org/W1602053154","https://openalex.org/W2055718756"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
