{"id":"https://openalex.org/W1978595257","doi":"https://doi.org/10.1007/s00438-011-0612-5","title":"EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases","display_name":"EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases","publication_year":2011,"publication_date":"2011-03-16","ids":{"openalex":"https://openalex.org/W1978595257","doi":"https://doi.org/10.1007/s00438-011-0612-5","mag":"1978595257","pmid":"https://pubmed.ncbi.nlm.nih.gov/21409565","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3064890"},"language":"en","primary_location":{"id":"doi:10.1007/s00438-011-0612-5","doi":"https://doi.org/10.1007/s00438-011-0612-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00438-011-0612-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00438-011-0612-5.pdf","source":{"id":"https://openalex.org/S129324922","display_name":"Molecular Genetics and Genomics","issn_l":"1617-4615","issn":["1617-4615","1617-4623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics and Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00438-011-0612-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008016536","display_name":"Isabelle Cousineau","orcid":"https://orcid.org/0000-0003-4116-6181","observed_orcids":["https://orcid.org/0000-0003-4116-6181"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Isabelle Cousineau","raw_affiliation_strings":["Department of Microbiology and Immunology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071285592","display_name":"Abdellah Belmaaza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107362","display_name":"H\u00f4pital Notre-Dame","ror":"https://ror.org/01w7qz648","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210107362","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4210142730","display_name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0410a8y51","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405273474","display_name":"Institut du cancer de Montr\u00e9al","ror":"https://ror.org/05w6ffd16","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I4405273474"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Abdellah Belmaaza","raw_affiliation_strings":["Centre de recherche, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), H\u00f4pital Notre-Dame, Institut du Cancer de Montr\u00e9al, 1560, rue Sherbrooke est, Pavillon J.A. de S\u00e8ve, Y-5634, Montr\u00e9al, QC, H2L 4M1, Canada","Department of Microbiology and Immunology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche, Centre hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CRCHUM), H\u00f4pital Notre-Dame, Institut du Cancer de Montr\u00e9al, 1560, rue Sherbrooke est, Pavillon J.A. de S\u00e8ve, Y-5634, Montr\u00e9al, QC, H2L 4M1, Canada","institution_ids":["https://openalex.org/I4210107362","https://openalex.org/I4210142730","https://openalex.org/I4405273474"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC, Canada","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5071285592"],"corresponding_institution_ids":["https://openalex.org/I4210107362","https://openalex.org/I4210142730","https://openalex.org/I4405273474","https://openalex.org/I70931966"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":{"value":3990,"currency":"USD","value_usd":3990},"fwci":1.9259,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.85765838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"285","issue":"4","first_page":"325","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emsy","display_name":"EMSY","score":0.9739999771118164},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rad51","display_name":"RAD51","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.921999990940094},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.7559999823570251},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7250000238418579},{"id":"https://openalex.org/keywords/palb2","display_name":"PALB2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/rpa","display_name":"RPA","score":0.984000027179718},{"id":"https://openalex.org/keywords/brca2-deficiency","display_name":"BRCA2 deficiency","score":0.5799999833106995},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5410000085830688},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.6990000009536743},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.45500001311302185},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.8548586368560791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7396577000617981},{"id":"https://openalex.org/C2778144015","wikidata":"https://www.wikidata.org/wiki/Q18046302","display_name":"PALB2","level":5,"score":0.6893107295036316},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6371456384658813},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6186231374740601},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6108320951461792},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5602272748947144},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45598888397216797},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.45468875765800476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45083415508270264},{"id":"https://openalex.org/C113271649","wikidata":"https://www.wikidata.org/wiki/Q2565234","display_name":"Replication protein A","level":5,"score":0.4354103207588196},{"id":"https://openalex.org/C2909462720","wikidata":"https://www.wikidata.org/wiki/Q421651","display_name":"BRCA2 Protein","level":5,"score":0.4342581629753113},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.42050012946128845},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.37083932757377625},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3489070534706116},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3308682143688202},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.31474989652633667},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.22517195343971252},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15648368000984192},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.15544843673706055},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.14914226531982422},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051135","descriptor_name":"Rad51 Recombinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051135","descriptor_name":"Rad51 Recombinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055029","descriptor_name":"Inverted Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00438-011-0612-5","doi":"https://doi.org/10.1007/s00438-011-0612-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00438-011-0612-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00438-011-0612-5.pdf","source":{"id":"https://openalex.org/S129324922","display_name":"Molecular Genetics and Genomics","issn_l":"1617-4615","issn":["1617-4615","1617-4623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics and Genomics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2088965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3064890","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21409565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21409565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular genetics and genomics : MGG","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3064890","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3064890/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Genet Genomics","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.2961","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.2961","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/4e/6c/Mol_Genet_Genomics_2011_Apr_16_285(4)_325-340.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1007/s00438-011-0612-5","doi":"https://doi.org/10.1007/s00438-011-0612-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00438-011-0612-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00438-011-0612-5.pdf","source":{"id":"https://openalex.org/S129324922","display_name":"Molecular Genetics and Genomics","issn_l":"1617-4615","issn":["1617-4615","1617-4623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics and Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319931","display_name":"Canadian Breast Cancer Research Alliance","ror":"https://ror.org/022mxs943"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320338030","display_name":"Institute of Cancer Research","ror":"https://ror.org/00dpztj76"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978595257.pdf","grobid_xml":"https://content.openalex.org/works/W1978595257.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1512321076","https://openalex.org/W1592309404","https://openalex.org/W1902479250","https://openalex.org/W1965239527","https://openalex.org/W1965749659","https://openalex.org/W1969513645","https://openalex.org/W1970785285","https://openalex.org/W1973771504","https://openalex.org/W1980707613","https://openalex.org/W1985663110","https://openalex.org/W1988157189","https://openalex.org/W1990709745","https://openalex.org/W1995691078","https://openalex.org/W1996270378","https://openalex.org/W1997589266","https://openalex.org/W2000465521","https://openalex.org/W2011912935","https://openalex.org/W2014084740","https://openalex.org/W2014766736","https://openalex.org/W2018458310","https://openalex.org/W2018867778","https://openalex.org/W2023353541","https://openalex.org/W2026673361","https://openalex.org/W2029090108","https://openalex.org/W2029468690","https://openalex.org/W2031105893","https://openalex.org/W2031176449","https://openalex.org/W2032301345","https://openalex.org/W2032907237","https://openalex.org/W2034702779","https://openalex.org/W2037798154","https://openalex.org/W2038698435","https://openalex.org/W2040644533","https://openalex.org/W2042499074","https://openalex.org/W2047277968","https://openalex.org/W2051409228","https://openalex.org/W2056490499","https://openalex.org/W2057275651","https://openalex.org/W2062226976","https://openalex.org/W2062284662","https://openalex.org/W2062568878","https://openalex.org/W2062837942","https://openalex.org/W2066969492","https://openalex.org/W2066975479","https://openalex.org/W2069103813","https://openalex.org/W2071411482","https://openalex.org/W2081963241","https://openalex.org/W2086333179","https://openalex.org/W2089159132","https://openalex.org/W2093814864","https://openalex.org/W2096870787","https://openalex.org/W2102370103","https://openalex.org/W2102922697","https://openalex.org/W2105707021","https://openalex.org/W2109630092","https://openalex.org/W2110235974","https://openalex.org/W2111772438","https://openalex.org/W2114725617","https://openalex.org/W2121141593","https://openalex.org/W2122205071","https://openalex.org/W2124371549","https://openalex.org/W2127566231","https://openalex.org/W2130447102","https://openalex.org/W2132505383","https://openalex.org/W2133386306","https://openalex.org/W2136399386","https://openalex.org/W2137408964","https://openalex.org/W2141579854","https://openalex.org/W2142864992","https://openalex.org/W2145540744","https://openalex.org/W2149795092","https://openalex.org/W2157936422","https://openalex.org/W2160272022","https://openalex.org/W2160278162","https://openalex.org/W2160532161","https://openalex.org/W2163968456","https://openalex.org/W2164458581","https://openalex.org/W2169939490","https://openalex.org/W2279453979","https://openalex.org/W2323963269","https://openalex.org/W3024340838"],"related_works":["https://openalex.org/W7095153505","https://openalex.org/W2077400398","https://openalex.org/W2017453661","https://openalex.org/W2296736803","https://openalex.org/W2029652905","https://openalex.org/W2122205071","https://openalex.org/W2578561521","https://openalex.org/W2604270594","https://openalex.org/W2154527822","https://openalex.org/W2407920585"],"abstract_inverted_index":{"EMSY":[0,30,58,83,133,165],"links":[1],"the":[2,17,41,47,65,103,115,153,179,205,241],"BRCA2":[3,18,33,44,88,155,169],"pathway":[4],"to":[5,16,55,72,152,213],"sporadic":[6],"breast/ovarian":[7,51],"cancer.":[8,52],"It":[9],"encodes":[10],"a":[11,62,121,129,161,218,228],"nuclear":[12],"protein":[13,111],"that":[14,82,96,128],"binds":[15],"N-terminal":[19],"domain":[20],"implicated":[21],"in":[22,46,64,89,132],"chromatin/transcription":[23,56],"regulation,":[24,57],"but":[25],"when":[26],"sporadically":[27],"amplified/overexpressed,":[28],"increased":[29],"level":[31,134],"represses":[32],"transactivation":[34],"potential":[35],"and":[36,92,105,113,148,176,184,187,200,237,255],"induces":[37],"chromosomal":[38],"instability,":[39],"mimicking":[40],"activity":[42],"of":[43,49,77,107,142,208,244],"mutations":[45],"development":[48],"hereditary":[50],"In":[53],"addition":[54],"may":[59,85,167,190,248],"also":[60,86,97],"play":[61],"role":[63],"DNA-damage":[66,90,183],"response,":[67],"suggested":[68],"by":[69,173,194],"its":[70,99,215],"ability":[71],"localize":[73],"at":[74,171,182,196],"chromatin":[75],"sites":[76],"DNA":[78,229],"damage/repair.":[79],"This":[80],"implies":[81],"overexpression":[84],"repress":[87,137],"replication/checkpoint":[91,110],"recombination/repair,":[93],"coordinated":[94],"processes":[95,140,193],"require":[98],"interacting":[100],"proteins:":[101],"PALB2,":[102,177],"partner":[104],"localizer":[106],"BRCA2;":[108],"RPA,":[109],"A;":[112],"RAD51,":[114],"inseparable":[116],"recombination/repair":[117,123],"enzyme.":[118],"Here,":[119],"using":[120],"well-characterized":[122],"assay":[124],"system,":[125],"we":[126],"demonstrate":[127],"slight":[130],"increase":[131],"can":[135,211],"indeed":[136],"these":[138,157,192],"two":[139],"independently":[141],"transcriptional":[143],"interference/repression.":[144],"Since":[145],"EMSY,":[146,198],"RPA":[147,175],"PALB2":[149,199],"all":[150],"bind":[151],"same":[154],"region,":[156],"findings":[158],"further":[159],"support":[160],"scenario":[162],"wherein:":[163],"(a)":[164],"amplification":[166],"mimic":[168],"deficiency,":[170],"least":[172,197],"overriding":[174],"crippling":[178],"BRCA2/RAD51":[180,189],"complex":[181],"replication/transcription":[185],"sites;":[186],"(b)":[188],"coordinate":[191],"employing":[195],"RPA.":[201],"We":[202],"extensively":[203],"discuss":[204],"molecular":[206],"details":[207],"how":[209],"this":[210],"happen":[212],"ascertain":[214],"implications":[216],"for":[217,232],"novel":[219],"recombination":[220],"mechanism":[221],"apparently":[222],"conceived":[223],"as":[224],"checkpoint":[225],"rather":[226],"than":[227],"repair":[230],"system":[231],"cell":[233],"division,":[234],"survival,":[235],"death,":[236],"human":[238],"diseases,":[239],"including":[240],"tissue":[242],"specificity":[243],"cancer":[245],"predisposition,":[246],"which":[247],"renew":[249],"our":[250],"thinking":[251],"about":[252],"targeted":[253],"therapy":[254],"prevention.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
