{"id":"https://openalex.org/W1978595151","doi":"https://doi.org/10.1021/bi701474t","title":"Structures and Micelle Locations of the Nonlipidated and Lipidated C-Terminal Membrane Anchor of 2\u2018,3\u2018-Cyclic Nucleotide-3\u2018-phosphodiesterase","display_name":"Structures and Micelle Locations of the Nonlipidated and Lipidated C-Terminal Membrane Anchor of 2\u2018,3\u2018-Cyclic Nucleotide-3\u2018-phosphodiesterase","publication_year":2007,"publication_date":"2007-12-13","ids":{"openalex":"https://openalex.org/W1978595151","doi":"https://doi.org/10.1021/bi701474t","mag":"1978595151","pmid":"https://pubmed.ncbi.nlm.nih.gov/18076147"},"language":"en","primary_location":{"id":"doi:10.1021/bi701474t","doi":"https://doi.org/10.1021/bi701474t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi701474t","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023768805","display_name":"Cinzia Esposito","orcid":"https://orcid.org/0009-0007-8211-0885","observed_orcids":["https://orcid.org/0009-0007-8211-0885"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Esposito","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015817418","display_name":"Mario Scrima","orcid":"https://orcid.org/0000-0002-0951-4353","observed_orcids":["https://orcid.org/0000-0002-0951-4353"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Scrima","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033213383","display_name":"Alfonso Carotenuto","orcid":"https://orcid.org/0000-0001-7532-5449","observed_orcids":["https://orcid.org/0000-0001-7532-5449"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfonso Carotenuto","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111850746","display_name":"Annamaria Tedeschi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annamaria Tedeschi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018078852","display_name":"Paolo Rovero","orcid":"https://orcid.org/0000-0001-9577-5228","observed_orcids":["https://orcid.org/0000-0001-9577-5228"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Rovero","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043177903","display_name":"Gerardino D\u2019Errico","orcid":"https://orcid.org/0000-0001-6383-8618","observed_orcids":["https://orcid.org/0000-0001-6383-8618"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gerardino D'Errico","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034331446","display_name":"Anna Maria Malfitano","orcid":"https://orcid.org/0000-0002-6193-2835","observed_orcids":["https://orcid.org/0000-0002-6193-2835"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Maria Malfitano","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023657474","display_name":"Maurizio Bifulco","orcid":"https://orcid.org/0000-0002-1771-4531","observed_orcids":["https://orcid.org/0000-0002-1771-4531"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Bifulco","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026154832","display_name":"Anna Maria D\u2019Ursi","orcid":"https://orcid.org/0000-0001-6814-8472","observed_orcids":["https://orcid.org/0000-0001-6814-8472"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Maria D'Ursi","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Salerno, I-84084 Fisciano, Italy, Department of Pharmaceutical and Toxicological Chemistry, University of Naples \u201cFederico II\u201d, I-80131 Naples, Italy, Laboratory of Peptide and Protein Chemistry and Biology, University of Florence, I-50019 Sesto Fiorentino, Italy, and Department of Chemistry, University of Naples \u201cFederico II\u201d, I-80126 Naples, Italy","institution_ids":["https://openalex.org/I131729948","https://openalex.org/I45084792","https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2132,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.45295413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"1","first_page":"308","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cnpase","display_name":"CNPase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cnp","display_name":"CNP","score":0.6589999794960022},{"id":"https://openalex.org/keywords/prenylation","display_name":"prenylation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/protein-isoprenylation","display_name":"isoprenylation","score":0.8399999737739563},{"id":"https://openalex.org/keywords/membrane-anchoring","display_name":"membrane anchoring","score":0.6650000214576721},{"id":"https://openalex.org/keywords/plasma-membrane-binding","display_name":"plasma membrane binding","score":0.5669999718666077},{"id":"https://openalex.org/keywords/lipidated-peptides","display_name":"lipidated peptides","score":0.5600000023841858},{"id":"https://openalex.org/keywords/peptide-conformation","display_name":"peptide conformation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/membrane-mimetic-environment","display_name":"membrane-mimetic environment","score":0.527999997138977},{"id":"https://openalex.org/keywords/myelin-associated-proteins","display_name":"myelin-associated proteins","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.6811381578445435},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6750813722610474},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.6589305400848389},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.593646764755249},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5883709192276001},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5764167308807373},{"id":"https://openalex.org/C193469717","wikidata":"https://www.wikidata.org/wiki/Q6556349","display_name":"Lipid-anchored protein","level":4,"score":0.55970299243927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5515239238739014},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.47553253173828125},{"id":"https://openalex.org/C2780215583","wikidata":"https://www.wikidata.org/wiki/Q946700","display_name":"Cyclic nucleotide phosphodiesterase","level":4,"score":0.4616151750087738},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4457218050956726},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.43815308809280396},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35291755199432373},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.31176334619522095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2127896547317505},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015087","descriptor_name":"2',3'-Cyclic-Nucleotide Phosphodiesterases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015087","descriptor_name":"2',3'-Cyclic-Nucleotide Phosphodiesterases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi701474t","doi":"https://doi.org/10.1021/bi701474t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi701474t","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:18076147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18076147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/354799","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/354799","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W177683657","https://openalex.org/W1491642680","https://openalex.org/W1530195638","https://openalex.org/W1534176032","https://openalex.org/W1602384986","https://openalex.org/W1756214111","https://openalex.org/W1857741797","https://openalex.org/W1972292461","https://openalex.org/W1976668067","https://openalex.org/W1978743038","https://openalex.org/W1990474655","https://openalex.org/W1994336523","https://openalex.org/W1997479694","https://openalex.org/W1997544416","https://openalex.org/W2000485285","https://openalex.org/W2002195659","https://openalex.org/W2006767915","https://openalex.org/W2007616938","https://openalex.org/W2010607678","https://openalex.org/W2015672226","https://openalex.org/W2017843643","https://openalex.org/W2018610390","https://openalex.org/W2024568684","https://openalex.org/W2025883914","https://openalex.org/W2026593599","https://openalex.org/W2034939522","https://openalex.org/W2035960224","https://openalex.org/W2041977309","https://openalex.org/W2045070954","https://openalex.org/W2052933818","https://openalex.org/W2057919740","https://openalex.org/W2058622897","https://openalex.org/W2067127132","https://openalex.org/W2069437912","https://openalex.org/W2074770586","https://openalex.org/W2077102218","https://openalex.org/W2083477605","https://openalex.org/W2083963151","https://openalex.org/W2086416551","https://openalex.org/W2088559308","https://openalex.org/W2088848851","https://openalex.org/W2089558887","https://openalex.org/W2093707752","https://openalex.org/W2104885939","https://openalex.org/W2128343653","https://openalex.org/W2140118120","https://openalex.org/W2140260269","https://openalex.org/W2141169592","https://openalex.org/W2145471850","https://openalex.org/W2171489482","https://openalex.org/W2176744910","https://openalex.org/W2186044714","https://openalex.org/W2224433893","https://openalex.org/W2949250147"],"related_works":["https://openalex.org/W2104885939","https://openalex.org/W7005243508","https://openalex.org/W1501146346","https://openalex.org/W1999164770","https://openalex.org/W2106977012","https://openalex.org/W7018267327","https://openalex.org/W7017606346","https://openalex.org/W6996358112","https://openalex.org/W2050584094","https://openalex.org/W169805374"],"abstract_inverted_index":{"2,3'-Cyclic":[0],"nucleotide-3'-phosphodiesterase":[1],"(CNP)":[2],"is":[3,41,50,63,76,190,208,215],"a":[4,51,80,107],"myelin-associated":[5],"protein,":[6],"an":[7,67,216],"enzyme":[8],"abundantly":[9],"present":[10],"in":[11,38,150,165,210],"the":[12,26,35,58,74,88,94,98,103,112,120,168,184,187,193,202,212,222,228,231],"central":[13],"nervous":[14],"system":[15],"of":[16,28,97,115,156,163,186,230],"mammals":[17],"and":[18,57,102,140,158,174,198,225],"some":[19],"vertebrates.":[20],"In":[21],"vitro,":[22],"CNP":[23,49,62,86,101,126,136],"specifically":[24],"catalyzes":[25],"hydrolysis":[27],"2',3'-cyclic":[29],"nucleotides":[30],"to":[31,78,87,110,119,131,147,167,195,220,226],"produce":[32],"2'-nucleotides,":[33],"but":[34],"physiologically":[36],"relevant":[37],"vivo":[39],"substrate":[40],"still":[42],"unknown.":[43],"Recently,":[44],"it":[45],"was":[46,129,170],"found":[47],"that":[48,183],"possible":[52],"linker":[53],"protein":[54,232],"between":[55,100],"microtubules":[56],"plasma":[59,89,104],"membranes.":[60],"Since":[61],"modified":[64],"post-translationally":[65],"by":[66,154,172],"isoprenylation":[68],"process":[69],"at":[70],"its":[71,141],"C":[72],"terminus,":[73],"prenylation":[75],"hypothesized":[77],"be":[79,132,196],"requisite":[81],"process,":[82],"which":[83,211],"permanently":[84],"anchors":[85],"membrane.":[90,121,234],"This":[91],"study":[92],"investigates":[93],"molecular":[95],"mechanism":[96],"interaction":[99],"membrane,":[105],"proposing":[106],"general":[108,206],"model":[109,207],"interpret":[111],"structural":[113,180],"bases":[114],"prenylated":[116],"proteins":[117],"binding":[118],"A":[122,205],"13":[123],"residue,":[124],"C-terminal":[125],"fragment,":[127],"C13,":[128],"demonstrated":[130],"directly":[133],"responsible":[134],"for":[135,192],"membrane":[137,151,169,203],"anchoring.":[138],"C13":[139,164],"lipidated":[142],"derivative":[143],"(LIPO-C13)":[144],"were":[145],"subjected":[146],"conformational":[148],"analysis":[149],"mimetic":[152],"environments,":[153],"means":[155],"CD":[157],"NMR":[159,173],"spectroscopies.":[160],"The":[161],"orientation":[162],"relation":[166],"investigated":[171],"EPR":[175],"spin":[176],"labeling":[177],"studies.":[178],"Our":[179],"investigation":[181],"shows":[182],"presence":[185],"lipidic":[188],"tail":[189],"essential":[191],"peptide":[194],"folded":[197],"correctly":[199],"positioned":[200],"on":[201],"surface.":[204],"proposed":[209],"post-translational":[213],"lipidation":[214],"important":[217],"biomolecular":[218],"trick":[219],"enlarge":[221],"hydrophobic":[223],"surface":[224],"enable":[227],"contact":[229],"with":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
