{"id":"https://openalex.org/W1978592015","doi":"https://doi.org/10.1530/jrf.0.1150001","title":"The Amoroso Lecture The human spermatozoon \u2013 a cell in crisis?","display_name":"The Amoroso Lecture The human spermatozoon \u2013 a cell in crisis?","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W1978592015","doi":"https://doi.org/10.1530/jrf.0.1150001","mag":"1978592015","pmid":"https://pubmed.ncbi.nlm.nih.gov/10341716"},"language":"en","primary_location":{"id":"doi:10.1530/jrf.0.1150001","doi":"https://doi.org/10.1530/jrf.0.1150001","is_oa":false,"landing_page_url":"https://doi.org/10.1530/jrf.0.1150001","pdf_url":null,"source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978592015"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088651676","display_name":"R. John Aitken","orcid":"https://orcid.org/0000-0002-9152-156X","observed_orcids":["https://orcid.org/0000-0002-9152-156X"]},"institutions":[{"id":"https://openalex.org/I4210116174","display_name":"MRC Centre for Reproductive Health","ror":"https://ror.org/02f4tsf92","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210116174","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"R John Aitken","raw_affiliation_strings":["MRC Reproductive Biology Unit, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Reproductive Biology Unit, Edinburgh, UK","institution_ids":["https://openalex.org/I4210116174"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088651676"],"corresponding_institution_ids":["https://openalex.org/I4210116174"],"apc_list":null,"apc_paid":null,"fwci":7.9134,"has_fulltext":false,"cited_by_count":429,"citation_normalized_percentile":{"value":0.98641349,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"115","issue":"1","first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermatozoa","display_name":"spermatozoa","score":0.7879999876022339},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8820000290870667},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.8500000238418579},{"id":"https://openalex.org/keywords/male-germ-cells","display_name":"male germ cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sperm-capacitation","display_name":"sperm capacitation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/sperm-dna-fragmentation","display_name":"sperm DNA fragmentation","score":0.847000002861023},{"id":"https://openalex.org/keywords/peroxidative-damage","display_name":"peroxidative damage","score":0.6539999842643738},{"id":"https://openalex.org/keywords/sperm-plasma-membrane","display_name":"sperm plasma membrane","score":0.8230000138282776},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.5379999876022339},{"id":"https://openalex.org/keywords/dna-condensation","display_name":"DNA condensation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/testicular-cancer","display_name":"testicular cancer","score":0.8510000109672546},{"id":"https://openalex.org/keywords/seminoma","display_name":"seminoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pediatric-cancer","display_name":"childhood cancer","score":0.5519999861717224},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2776632385","wikidata":"https://www.wikidata.org/wiki/Q74560","display_name":"Spermatozoon","level":3,"score":0.8015433549880981},{"id":"https://openalex.org/C2780301668","wikidata":"https://www.wikidata.org/wiki/Q1728362","display_name":"Capacitation","level":3,"score":0.7645142674446106},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.7303997278213501},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.5558006763458252},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.535087525844574},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5214576125144958},{"id":"https://openalex.org/C2778093475","wikidata":"https://www.wikidata.org/wiki/Q9715","display_name":"Semen","level":2,"score":0.45751896500587463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.446557879447937},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.4219841957092285},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41444748640060425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3362540006637573},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3314005136489868},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2645149230957031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24487334489822388},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24260374903678894},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20598462224006653},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014998","descriptor_name":"Y Chromosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018239","descriptor_name":"Seminoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018239","descriptor_name":"Seminoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1530/jrf.0.1150001","doi":"https://doi.org/10.1530/jrf.0.1150001","is_oa":false,"landing_page_url":"https://doi.org/10.1530/jrf.0.1150001","pdf_url":null,"source":{"id":"https://openalex.org/S28473761","display_name":"Reproduction","issn_l":"1470-1626","issn":["1470-1626","1741-7899"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproduction","raw_type":"journal-article"},{"id":"pmid:10341716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10341716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of reproduction and fertility","raw_type":"Lecture"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.933.4768","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.933.4768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.reproduction-online.org/content/115/1/1.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2155948635","https://openalex.org/W1975223491","https://openalex.org/W4236666213","https://openalex.org/W2741777229","https://openalex.org/W1931312153","https://openalex.org/W1835082915","https://openalex.org/W2801569733","https://openalex.org/W2808545766","https://openalex.org/W2013277450"],"abstract_inverted_index":{"A":[0],"great":[1],"deal":[2],"of":[3,33,53,91,108,135,144,148],"evidence":[4],"has":[5,14],"accumulated":[6],"in":[7,19,64,96,123,132,141,177],"recent":[8,139],"years":[9],"to":[10,50,57,71,88,115],"suggest":[11],"that":[12,44,85,167],"there":[13],"been":[15],"a":[16,81,106],"gradual":[17],"increase":[18],"male":[20,54,125,160],"reproductive":[21],"pathology":[22],"over":[23],"the":[24,51,89,99,116,124,133,142,152,159,165],"past":[25],"30-40":[26],"years,":[27],"as":[28],"evidenced":[29],"by":[30,75,158],"increased":[31],"rates":[32],"testicular":[34],"cancer":[35,137],"and":[36,79,105,138,163],"declining":[37],"semen":[38],"quality.":[39],"The":[40],"hypothesis":[41],"is":[42,47,86],"advanced":[43],"this":[45,169,178],"phenomenon":[46],"causally":[48],"related":[49],"ability":[52],"germ":[55,126,161],"cells":[56],"generate":[58],"reactive":[59],"oxygen":[60],"metabolites.":[61],"When":[62,94],"produced":[63,95],"low":[65],"levels,":[66],"such":[67],"metabolites":[68,101],"are":[69,171],"thought":[70],"enhance":[72],"sperm":[73,92,109,117],"function":[74,110],"stimulating":[76],"DNA":[77,103],"compaction":[78],"promoting":[80],"redox-regulated":[82],"cAMP-mediated":[83],"pathway":[84],"central":[87],"induction":[90],"capacitation.":[93],"excessive":[97],"amounts,":[98],"same":[100],"stimulate":[102],"fragmentation":[104],"loss":[107],"associated":[111],"with":[112],"peroxidative":[113],"damage":[114],"plasma":[118],"membrane.":[119],"Free":[120],"radical-induced":[121],"mutations":[122],"line":[127,162],"may":[128],"also":[129],"be":[130],"involved":[131],"aetiology":[134],"childhood":[136],"increases":[140],"incidence":[143],"seminoma.":[145],"In":[146],"light":[147],"these":[149],"considerations,":[150],"establishing":[151],"mechanisms":[153],"for":[154,174],"free":[155],"radical":[156],"generation":[157],"determining":[164],"factors":[166],"influence":[168],"activity":[170],"important":[172],"objectives":[173],"future":[175],"research":[176],"area.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
