{"id":"https://openalex.org/W1978587779","doi":"https://doi.org/10.1109/tbme.2012.2227256","title":"An Online Failure Detection Method of the Glucose Sensor-Insulin Pump System: Improved Overnight Safety of Type-1 Diabetic Subjects","display_name":"An Online Failure Detection Method of the Glucose Sensor-Insulin Pump System: Improved Overnight Safety of Type-1 Diabetic Subjects","publication_year":2012,"publication_date":"2012-11-21","ids":{"openalex":"https://openalex.org/W1978587779","doi":"https://doi.org/10.1109/tbme.2012.2227256","mag":"1978587779","pmid":"https://pubmed.ncbi.nlm.nih.gov/23193300"},"language":"en","primary_location":{"id":"doi:10.1109/tbme.2012.2227256","doi":"https://doi.org/10.1109/tbme.2012.2227256","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2227256","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081035885","display_name":"Andrea Facchinetti","orcid":"https://orcid.org/0000-0001-8041-2280","observed_orcids":["https://orcid.org/0000-0001-8041-2280"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Facchinetti","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy","Department of Information Engineering, University of Padova , Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Information Engineering, University of Padova , Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013219153","display_name":"Simone Del Favero","orcid":"https://orcid.org/0000-0002-8214-2752","observed_orcids":["https://orcid.org/0000-0002-8214-2752"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Favero","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy","Department of Information Engineering, University of Padova , Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Information Engineering, University of Padova , Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071251680","display_name":"Giovanni Sparacino","orcid":"https://orcid.org/0000-0002-3248-1393","observed_orcids":["https://orcid.org/0000-0002-3248-1393"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Sparacino","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy","Department of Information Engineering, University of Padova , Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Information Engineering, University of Padova , Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026228486","display_name":"Claudio Cobelli","orcid":"https://orcid.org/0000-0002-0169-6682","observed_orcids":["https://orcid.org/0000-0002-0169-6682"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudio Cobelli","raw_affiliation_strings":["Department of Information Engineering, University of Padova, Padova, Italy","Department of Information Engineering, University of Padova , Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Padova, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Information Engineering, University of Padova , Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138689650"],"apc_list":{"value":2645,"currency":"USD","value_usd":2645},"apc_paid":null,"fwci":2.0818,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.86010459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"60","issue":"2","first_page":"406","last_page":"416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10876","display_name":"Fault Detection and Control Systems","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10793","display_name":"Diabetes Management and Education","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fault-detection","display_name":"fault detection","score":0.8180000185966492},{"id":"https://openalex.org/keywords/continuous-glucose-monitoring","display_name":"continuous glucose monitoring","score":0.8140000104904175},{"id":"https://openalex.org/keywords/continuous-subcutaneous-insulin-infusion","display_name":"insulin pump therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glucose-insulin-system","display_name":"glucose-insulin system","score":0.6809999942779541},{"id":"https://openalex.org/keywords/state-space-identification","display_name":"state-space model identification","score":0.8489999771118164},{"id":"https://openalex.org/keywords/kalman-filter","display_name":"Kalman filter","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glucose-prediction","display_name":"glucose prediction","score":0.5210000276565552},{"id":"https://openalex.org/keywords/confidence-intervals","display_name":"confidence intervals","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sensor-faults","display_name":"sensor faults","score":0.4860000014305115},{"id":"https://openalex.org/keywords/pump-failure","display_name":"pump failure","score":0.7519999742507935},{"id":"https://openalex.org/keywords/uva-padova-simulator","display_name":"UVA/Padova simulator","score":0.6539999842643738},{"id":"https://openalex.org/keywords/virtual-patients","display_name":"virtual patients","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2779794567","wikidata":"https://www.wikidata.org/wiki/Q941674","display_name":"Insulin pump","level":4,"score":0.7757944464683533},{"id":"https://openalex.org/C2986379492","wikidata":"https://www.wikidata.org/wiki/Q1638492","display_name":"Continuous glucose monitoring","level":4,"score":0.7539628744125366},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6270521879196167},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5928940176963806},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.5824898481369019},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.48404353857040405},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4722294807434082},{"id":"https://openalex.org/C2994527087","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin delivery","level":4,"score":0.45426905155181885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4395821690559387},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42107588052749634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23185992240905762},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20271649956703186},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17925581336021423}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007332","descriptor_name":"Insulin Infusion Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D015190","descriptor_name":"Blood Glucose Self-Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/tbme.2012.2227256","doi":"https://doi.org/10.1109/tbme.2012.2227256","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tbme.2012.2227256","pdf_url":null,"source":{"id":"https://openalex.org/S5240358","display_name":"IEEE Transactions on Biomedical Engineering","issn_l":"0018-9294","issn":["0018-9294","1558-2531"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:23193300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23193300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE transactions on bio-medical engineering","raw_type":"Journal Article"},{"id":"pmh:oai:www.research.unipd.it:11577/2532007","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2532007","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1531505795","https://openalex.org/W1964143445","https://openalex.org/W1966562602","https://openalex.org/W1971138560","https://openalex.org/W1973641708","https://openalex.org/W1973697640","https://openalex.org/W1977806121","https://openalex.org/W1993512164","https://openalex.org/W1993959942","https://openalex.org/W2006053166","https://openalex.org/W2023460020","https://openalex.org/W2031534975","https://openalex.org/W2035642677","https://openalex.org/W2048001554","https://openalex.org/W2058101613","https://openalex.org/W2061177409","https://openalex.org/W2092619316","https://openalex.org/W2101539208","https://openalex.org/W2111485734","https://openalex.org/W2111804091","https://openalex.org/W2123628675","https://openalex.org/W2134017961","https://openalex.org/W2139057798","https://openalex.org/W2142433802","https://openalex.org/W2147750301","https://openalex.org/W2158711921","https://openalex.org/W2160380347","https://openalex.org/W2162557622","https://openalex.org/W2527081555"],"related_works":["https://openalex.org/W1548320922","https://openalex.org/W7029161519","https://openalex.org/W2014292777","https://openalex.org/W4252402901","https://openalex.org/W641466127","https://openalex.org/W3195401720","https://openalex.org/W2326424483","https://openalex.org/W3036287993","https://openalex.org/W7108073175","https://openalex.org/W1996070385"],"abstract_inverted_index":{"Sensors":[0],"for":[1,9,19,152],"real-time":[2,103],"continuous":[3,10],"glucose":[4,114,128,188],"monitoring":[5],"(CGM)":[6],"and":[7,63,67,89,101,190,220],"pumps":[8],"subcutaneous":[11],"insulin":[12,43],"infusion":[13],"(CSII)":[14],"have":[15,176],"opened":[16],"new":[17],"scenarios":[18],"Type-1":[20,168,268],"diabetes":[21],"treatment.":[22],"However,":[23],"occasional":[24],"failures":[25,58,175,256],"of":[26,71,80,112,174,185,187,196,217,223,233,247,255,257,267],"either":[27],"CGM":[28,62,88,100,133,182,259],"or":[29],"CSII":[30,64,90,102],"may":[31],"expose":[32],"diabetic":[33,169,269],"patients":[34,162,270],"to":[35,52,109,148,208],"possibly":[36],"severe":[37],"risks,":[38],"especially":[39],"overnight":[40],"(e.g.,":[41],"inappropriate":[42],"administration).":[44],"In":[45],"this":[46,98],"contribution,":[47],"we":[48],"present":[49],"a":[50,68,94,123,141,213,221],"method":[51,156,205,235,249],"detect":[53],"in":[54,146,180,192,201,236,250,253],"real":[55],"time":[56],"such":[57],"by":[59,121,131,164],"simultaneously":[60],"using":[61,165],"data":[65,91,104],"streams":[66,105],"black-box":[69],"model":[70,79],"the":[72,81,132,139,150,166,181,193,204,234,240,245,248,258],"glucose-insulin":[73,82],"system.":[74],"First,":[75],"an":[76],"individualized":[77],"state-space":[78],"system":[83,262],"is":[84,144,157,206],"identified":[85],"offline":[86],"from":[87],"collected":[92],"during":[93],"previous":[95],"monitoring.":[96],"Then,":[97],"model,":[99],"are":[106,135],"used":[107],"online":[108],"obtain":[110],"predictions":[111],"future":[113],"concentrations":[115],"together":[116],"with":[117,138,212],"their":[118],"confidence":[119],"intervals":[120],"exploiting":[122],"Kalman":[124],"filtering":[125],"approach.":[126],"If":[127],"values":[129],"measured":[130],"sensor":[134],"not":[136],"consistent":[137],"predictions,":[140],"failure":[142,191],"alert":[143],"generated":[145],"order":[147],"mitigate":[149],"risks":[151],"patient":[153],"safety.":[154],"The":[155,231],"tested":[158],"on":[159,226],"100":[160],"virtual":[161],"created":[163],"UVA/Padova":[167],"simulator.":[170],"Three":[171],"different":[172],"types":[173],"been":[177],"simulated:":[178],"spike":[179],"profile,":[183],"loss":[184],"sensitivity":[186],"sensor,":[189],"pump":[194,261],"delivery":[195],"insulin.":[197],"Results":[198],"show":[199],"that,":[200],"all":[202],"cases,":[203],"able":[207],"correctly":[209],"generate":[210],"alerts,":[211],"very":[214],"limited":[215],"number":[216,222],"false":[218,224],"negatives":[219],"positives,":[225],"average,":[227],"lower":[228],"than":[229],"10%.":[230],"use":[232],"three":[237],"subjects":[238],"supports":[239],"simulation":[241],"results,":[242],"demonstrating":[243],"that":[244],"accuracy":[246],"generating":[251],"alerts":[252],"presence":[254],"sensor-CSII":[260],"can":[263],"significantly":[264],"improve":[265],"safety":[266],"overnight.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}