{"id":"https://openalex.org/W1978585202","doi":"https://doi.org/10.1074/jbc.m212750200","title":"Characterization of Insulin Inhibition of Transactivation by a C-terminal Fragment of the Forkhead Transcription Factor Foxo1 in Rat Hepatoma Cells","display_name":"Characterization of Insulin Inhibition of Transactivation by a C-terminal Fragment of the Forkhead Transcription Factor Foxo1 in Rat Hepatoma Cells","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W1978585202","doi":"https://doi.org/10.1074/jbc.m212750200","mag":"1978585202","pmid":"https://pubmed.ncbi.nlm.nih.gov/12724332"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m212750200","doi":"https://doi.org/10.1074/jbc.m212750200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m212750200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m212750200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104992180","display_name":"Val\u00e9rie Perrot","orcid":"https://orcid.org/0000-0002-5541-728X","observed_orcids":["https://orcid.org/0000-0002-5541-728X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Val\u00e9rie Perrot","raw_affiliation_strings":["Growth and Development Section, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth and Development Section, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084959996","display_name":"Matthew M. Rechler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew M. Rechler","raw_affiliation_strings":["Growth and Development Section, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth and Development Section, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104992180"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.6894,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.64225771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"278","issue":"28","first_page":"26111","last_page":"26119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxo1","display_name":"FOXO1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7039999961853027},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7289999723434448},{"id":"https://openalex.org/keywords/forkhead-box-transcription-factors","display_name":"forkhead transcription factor","score":0.8019999861717224},{"id":"https://openalex.org/keywords/pi-3-kinase","display_name":"PI3-kinase","score":0.8019999861717224},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/c-terminal-fragment","display_name":"C-terminal fragment","score":0.5550000071525574},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.6349999904632568},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.5600000023841858},{"id":"https://openalex.org/keywords/h4iie-cells","display_name":"H4IIE cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/gal4-fusion-proteins","display_name":"GAL4 fusion proteins","score":0.6110000014305115},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.9593791961669922},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.8962174654006958},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.689599871635437},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6570559144020081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5246244072914124},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.49002277851104736},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34285277128219604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33843040466308594},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2362310290336609},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18041878938674927}],"mesh":[{"descriptor_ui":"D000071161","descriptor_name":"Forkhead Box Protein O1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m212750200","doi":"https://doi.org/10.1074/jbc.m212750200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m212750200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12724332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12724332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m212750200","doi":"https://doi.org/10.1074/jbc.m212750200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m212750200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1503259740","https://openalex.org/W1547877665","https://openalex.org/W1552883645","https://openalex.org/W1625966995","https://openalex.org/W1631908837","https://openalex.org/W1652264402","https://openalex.org/W1964064482","https://openalex.org/W1965947775","https://openalex.org/W1970471141","https://openalex.org/W1972239225","https://openalex.org/W1972766406","https://openalex.org/W1973283904","https://openalex.org/W1976050844","https://openalex.org/W1977795081","https://openalex.org/W1979147887","https://openalex.org/W1986065867","https://openalex.org/W1991174835","https://openalex.org/W1994096575","https://openalex.org/W1995514532","https://openalex.org/W1997520549","https://openalex.org/W2000440562","https://openalex.org/W2001001554","https://openalex.org/W2005321199","https://openalex.org/W2006796385","https://openalex.org/W2007530728","https://openalex.org/W2011785467","https://openalex.org/W2012349288","https://openalex.org/W2016356782","https://openalex.org/W2022416092","https://openalex.org/W2023973783","https://openalex.org/W2024529788","https://openalex.org/W2032989528","https://openalex.org/W2035414423","https://openalex.org/W2035936653","https://openalex.org/W2036837630","https://openalex.org/W2037100222","https://openalex.org/W2038163496","https://openalex.org/W2046623154","https://openalex.org/W2047519730","https://openalex.org/W2050627047","https://openalex.org/W2051028757","https://openalex.org/W2054193823","https://openalex.org/W2056919828","https://openalex.org/W2060116181","https://openalex.org/W2060763966","https://openalex.org/W2061617907","https://openalex.org/W2062629127","https://openalex.org/W2064013576","https://openalex.org/W2067799923","https://openalex.org/W2075044481","https://openalex.org/W2075496313","https://openalex.org/W2075663382","https://openalex.org/W2076262819","https://openalex.org/W2081359005","https://openalex.org/W2084143461","https://openalex.org/W2084986953","https://openalex.org/W2087085892","https://openalex.org/W2087247206","https://openalex.org/W2087312926","https://openalex.org/W2089295555","https://openalex.org/W2100943227","https://openalex.org/W2104064337","https://openalex.org/W2104969843","https://openalex.org/W2107664641","https://openalex.org/W2108197605","https://openalex.org/W2113002082","https://openalex.org/W2122000735","https://openalex.org/W2123922689","https://openalex.org/W2127337885","https://openalex.org/W2134199670","https://openalex.org/W2137035181","https://openalex.org/W2154657445","https://openalex.org/W2160547697","https://openalex.org/W2160746910","https://openalex.org/W2162193671","https://openalex.org/W2164796388","https://openalex.org/W2165863663","https://openalex.org/W2166525118","https://openalex.org/W2168224573","https://openalex.org/W2169494292","https://openalex.org/W2414461543"],"related_works":["https://openalex.org/W2029503131","https://openalex.org/W2024529788","https://openalex.org/W1480414623","https://openalex.org/W1983413366","https://openalex.org/W1985478578","https://openalex.org/W1991174835","https://openalex.org/W2094149948","https://openalex.org/W4237415140","https://openalex.org/W2041478818","https://openalex.org/W2127337885"],"abstract_inverted_index":{"The":[0],"transcription":[1,60,234],"factor":[2],"Foxo1":[3,21,48,67,96,124,208,236],"controls":[4],"the":[5,55,64,69,77,83,101,107,151,161,204,230],"expression":[6],"of":[7,47,57,66,80,95,132,150,197,207,233,235],"genes":[8,238],"involved":[9],"in":[10,26,54,90,125,141,160],"fundamental":[11],"cellular":[12],"processes.":[13],"In":[14,82],"keeping":[15],"with":[16],"its":[17],"important":[18],"physiological":[19],"roles,":[20],"activity":[22,206],"is":[23,72,104,135,209],"negatively":[24],"regulated":[25,210],"response":[27],"to":[28,52,62,75,106,143],"growth":[29],"factors":[30],"and":[31,61,157,166,176,189,222],"cytokines":[32],"that":[33,117,191,203],"activate":[34],"a":[35,87,92,181],"phosphatidylinositol":[36],"3-kinase":[37,139],"(PI":[38],"3-kinase)":[39],"protein":[40,89,162],"kinase":[41],"B":[42],"(PKB)/Akt":[43],"pathway.":[44],"PKB/Akt-mediated":[45],"phosphorylation":[46,154,173],"has":[49],"been":[50],"shown":[51],"result":[53],"inhibition":[56,131,196],"target":[58,237],"gene":[59],"trigger":[63],"export":[65],"from":[68],"nucleus,":[70],"which":[71,91],"generally":[73],"believed":[74],"explain":[76],"subsequent":[78],"decrease":[79],"transcription.":[81],"present":[84,114,159],"study,":[85],"using":[86],"chimeric":[88],"C-terminal":[93],"fragment":[94],"(amino":[97],"acids":[98],"208-652)":[99],"containing":[100],"transactivation":[102,122,134,198],"domain":[103],"fused":[105],"yeast":[108],"Gal4":[109],"DNA":[110,220],"binding":[111,221],"domain,":[112],"we":[113,169],"evidence":[115],"showing":[116],"insulin":[118,195],"can":[119],"directly":[120],"regulate":[121],"by":[123,137,199,214,239],"H4IIE":[126],"rat":[127],"hepatoma":[128],"cells.":[129],"Insulin":[130],"Foxo1-(208-652)-stimulated":[133],"mediated":[136],"PI":[138],"but":[140],"contrast":[142],"full-length":[144],"Foxo1,":[145],"does":[146],"not":[147],"require":[148],"either":[149],"two":[152,171],"PKB/Akt":[153],"sites":[155],"(Ser253":[156],"Ser316)":[158],"fragment.":[163],"Using":[164],"mutational":[165],"deletion":[167],"studies,":[168],"identify":[170],"potential":[172],"sites,":[174],"Ser319":[175],"Ser499,":[177],"as":[178,180,217,219],"well":[179,218],"15-amino":[182],"acid":[183],"region":[184],"located":[185],"between":[186],"residues":[187],"350":[188],"364":[190],"are":[192],"critical":[193],"for":[194],"Foxo1-(208-652).":[200],"We":[201],"conclude":[202],"transcriptional":[205],"at":[211],"different":[212,226],"levels":[213],"insulin:":[215],"transactivation,":[216],"nuclear":[223],"exclusion.":[224],"These":[225],"regulatory":[227],"mechanisms":[228],"allow":[229],"precise":[231],"control":[232],"insulin.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
