{"id":"https://openalex.org/W1978585175","doi":"https://doi.org/10.1016/j.biomaterials.2004.06.010","title":"The decrease of particle-induced osteolysis after a single dose of bisphosphonate","display_name":"The decrease of particle-induced osteolysis after a single dose of bisphosphonate","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W1978585175","doi":"https://doi.org/10.1016/j.biomaterials.2004.06.010","mag":"1978585175","pmid":"https://pubmed.ncbi.nlm.nih.gov/15576154"},"language":"en","primary_location":{"id":"doi:10.1016/j.biomaterials.2004.06.010","doi":"https://doi.org/10.1016/j.biomaterials.2004.06.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2004.06.010","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072370851","display_name":"Marius von Knoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marius von Knoch","raw_affiliation_strings":["Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany. mariusvonknoch@yahoo.com","Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany. mariusvonknoch@yahoo.com","institution_ids":["https://openalex.org/I62318514"]},{"raw_affiliation_string":"Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086358349","display_name":"Christian Wedemeyer","orcid":"https://orcid.org/0000-0002-3914-0209","observed_orcids":["https://orcid.org/0000-0002-3914-0209"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Wedemeyer","raw_affiliation_strings":["Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005587720","display_name":"Andreas Pingsmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Pingsmann","raw_affiliation_strings":["Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111675681","display_name":"Fabian von Knoch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148531","display_name":"Kantonsspital Graub\u00fcnden","ror":"https://ror.org/04wpn1218","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210148531"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fabian von Knoch","raw_affiliation_strings":["Department of Surgery, Raetisches Kantons- und Regionalspital, 7000 Chur, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Raetisches Kantons- und Regionalspital, 7000 Chur, Switzerland","institution_ids":["https://openalex.org/I4210148531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009949474","display_name":"Gero Hilken","orcid":"https://orcid.org/0000-0002-3881-796X","observed_orcids":["https://orcid.org/0000-0002-3881-796X"]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gero Hilken","raw_affiliation_strings":["Central Animal Laboratory, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Animal Laboratory, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089967923","display_name":"Christoph M. Sprecher","orcid":"https://orcid.org/0000-0002-5043-1066","observed_orcids":["https://orcid.org/0000-0002-5043-1066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Sprecher","raw_affiliation_strings":["AO Research Institute, Clavadelerstrasse, 7270 Davos, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AO Research Institute, Clavadelerstrasse, 7270 Davos, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071662260","display_name":"Frank Henschke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Henschke","raw_affiliation_strings":["Pathologisches Institut am Johannisstift, Reumontstrasse 28, 33102 Paderborn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathologisches Institut am Johannisstift, Reumontstrasse 28, 33102 Paderborn, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074874440","display_name":"Bertram Barden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bertram Barden","raw_affiliation_strings":["Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108215977","display_name":"F. L\u00f6er","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz L\u00f6er","raw_affiliation_strings":["Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, University of Duisburg-Essen, Pattbergstrasse 1-3, 45239 Essen, Germany","institution_ids":["https://openalex.org/I62318514"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072370851"],"corresponding_institution_ids":["https://openalex.org/I62318514"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":6.4438,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.96384194,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"14","first_page":"1803","last_page":"1808"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/particle-induced-osteolysis","display_name":"particle-induced osteolysis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9800000190734863},{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/single-dose-treatment","display_name":"single-dose therapy","score":0.6949999928474426},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8040000200271606},{"id":"https://openalex.org/keywords/aseptic-loosening","display_name":"aseptic loosening","score":0.8679999709129333},{"id":"https://openalex.org/keywords/joint-replacement","display_name":"joint replacement","score":0.8190000057220459},{"id":"https://openalex.org/keywords/implant-failure","display_name":"implant failure","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2781282405","wikidata":"https://www.wikidata.org/wiki/Q2035084","display_name":"Osteolysis","level":2,"score":0.9182345867156982},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.7518078088760376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6815794110298157},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.6769920587539673},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.6561518907546997},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.6316200494766235},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.4285178482532501},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4018439054489136},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3706204295158386},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.33546799421310425},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.27412739396095276},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22446128726005554},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14506614208221436},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077211","descriptor_name":"Zoledronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005549","descriptor_name":"Foreign-Body Reaction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005549","descriptor_name":"Foreign-Body Reaction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005549","descriptor_name":"Foreign-Body Reaction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020959","descriptor_name":"Polyethylene","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biomaterials.2004.06.010","doi":"https://doi.org/10.1016/j.biomaterials.2004.06.010","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2004.06.010","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},{"id":"pmid:15576154","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15576154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"Journal Article"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00015656","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pubmed/15576154","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W26451882","https://openalex.org/W1831604303","https://openalex.org/W1836348293","https://openalex.org/W1977147557","https://openalex.org/W1978228601","https://openalex.org/W1994414479","https://openalex.org/W2018526774","https://openalex.org/W2034427928","https://openalex.org/W2049094462","https://openalex.org/W2053286399","https://openalex.org/W2061235833","https://openalex.org/W2069543291","https://openalex.org/W2074890088","https://openalex.org/W2133955518","https://openalex.org/W2160211410","https://openalex.org/W2170680219","https://openalex.org/W2245567567","https://openalex.org/W3143184174","https://openalex.org/W4249814361","https://openalex.org/W4252639760","https://openalex.org/W4285719527","https://openalex.org/W4292824376"],"related_works":["https://openalex.org/W1538657180","https://openalex.org/W2133955518","https://openalex.org/W6940207827","https://openalex.org/W2768616513","https://openalex.org/W2144390061","https://openalex.org/W2010074304","https://openalex.org/W2027265280","https://openalex.org/W2049094462","https://openalex.org/W1979794577","https://openalex.org/W2351597484"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}