{"id":"https://openalex.org/W1978580979","doi":"https://doi.org/10.1091/mbc.6.11.1549","title":"The dynein genes of Paramecium tetraurelia: the structure and expression of the ciliary beta and cytoplasmic heavy chains.","display_name":"The dynein genes of Paramecium tetraurelia: the structure and expression of the ciliary beta and cytoplasmic heavy chains.","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W1978580979","doi":"https://doi.org/10.1091/mbc.6.11.1549","mag":"1978580979","pmid":"https://pubmed.ncbi.nlm.nih.gov/8589455","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/301310"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.6.11.1549","doi":"https://doi.org/10.1091/mbc.6.11.1549","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.6.11.1549","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/301310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023174370","display_name":"Kimberly Kandl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K A Kandl","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082657792","display_name":"JAMES D. FORNEY","orcid":"https://orcid.org/0000-0002-6144-732X","observed_orcids":["https://orcid.org/0000-0002-6144-732X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J D Forney","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110620168","display_name":"David J. Asai","orcid":"https://orcid.org/0009-0008-1567-1620","observed_orcids":["https://orcid.org/0009-0008-1567-1620"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J Asai","raw_affiliation_strings":["Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":1.4551,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.81435924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"6","issue":"11","first_page":"1549","last_page":"1562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynein-heavy-chain","display_name":"dynein heavy chain","score":0.8489999771118164},{"id":"https://openalex.org/keywords/paramecium-tetraurelia","display_name":"Paramecium tetraurelia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cytoplasmic-dynein","display_name":"cytoplasmic dynein","score":0.9409999847412109},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.6380000114440918},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7269999980926514},{"id":"https://openalex.org/keywords/deciliation","display_name":"deciliation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/axonemal-dynein","display_name":"axonemal dynein","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tail-domain","display_name":"tail domain","score":0.7120000123977661},{"id":"https://openalex.org/keywords/catalytic-domain","display_name":"catalytic domain","score":0.8510000109672546},{"id":"https://openalex.org/keywords/protein-isoforms","display_name":"protein isoforms","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.9516327381134033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8425061702728271},{"id":"https://openalex.org/C2780536333","wikidata":"https://www.wikidata.org/wiki/Q199456","display_name":"Paramecium","level":2,"score":0.781946063041687},{"id":"https://openalex.org/C134729014","wikidata":"https://www.wikidata.org/wiki/Q21105411","display_name":"Dynactin","level":4,"score":0.7355203032493591},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5572512745857239},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.5557726621627808},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5547437071800232},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5231531858444214},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.49040794372558594},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4657970368862152},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3700842261314392},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3374186158180237},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.3306353986263275},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.07407176494598389},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004398","descriptor_name":"Dyneins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004398","descriptor_name":"Dyneins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004398","descriptor_name":"Dyneins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015698","descriptor_name":"Genomic Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016805","descriptor_name":"Paramecium tetraurelia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016805","descriptor_name":"Paramecium tetraurelia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016805","descriptor_name":"Paramecium tetraurelia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017125","descriptor_name":"Genes, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1091/mbc.6.11.1549","doi":"https://doi.org/10.1091/mbc.6.11.1549","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.6.11.1549","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1313710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/301310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:301310","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/301310","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:8589455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8589455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1313710","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/301310","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2567534178","display_name":null,"funder_award_id":"GM49889","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4098994662","display_name":"DYNEIN ISOFORMS IN PARAMECIUM","funder_award_id":"5r01gm049889-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1485787263","https://openalex.org/W1487339116","https://openalex.org/W1510528711","https://openalex.org/W1532114873","https://openalex.org/W1555183220","https://openalex.org/W1581760465","https://openalex.org/W1589847991","https://openalex.org/W1885939991","https://openalex.org/W1908837652","https://openalex.org/W1911359980","https://openalex.org/W1968307284","https://openalex.org/W1975223679","https://openalex.org/W1976905813","https://openalex.org/W1977610387","https://openalex.org/W1983036595","https://openalex.org/W1984915878","https://openalex.org/W1985693768","https://openalex.org/W1994731872","https://openalex.org/W2004349861","https://openalex.org/W2009131721","https://openalex.org/W2010675166","https://openalex.org/W2011730020","https://openalex.org/W2012658249","https://openalex.org/W2020021303","https://openalex.org/W2021673452","https://openalex.org/W2023281151","https://openalex.org/W2030463073","https://openalex.org/W2030611496","https://openalex.org/W2034269295","https://openalex.org/W2042850143","https://openalex.org/W2045922259","https://openalex.org/W2050352537","https://openalex.org/W2050752020","https://openalex.org/W2057145553","https://openalex.org/W2057963096","https://openalex.org/W2065337493","https://openalex.org/W2066272395","https://openalex.org/W2073145130","https://openalex.org/W2078352395","https://openalex.org/W2081762142","https://openalex.org/W2083068431","https://openalex.org/W2083704406","https://openalex.org/W2089781362","https://openalex.org/W2091247237","https://openalex.org/W2091556621","https://openalex.org/W2099787706","https://openalex.org/W2099904614","https://openalex.org/W2104175575","https://openalex.org/W2106024132","https://openalex.org/W2108388593","https://openalex.org/W2111979049","https://openalex.org/W2112610606","https://openalex.org/W2113503326","https://openalex.org/W2118045551","https://openalex.org/W2118642774","https://openalex.org/W2119103022","https://openalex.org/W2120375547","https://openalex.org/W2122744558","https://openalex.org/W2133220411","https://openalex.org/W2139192787","https://openalex.org/W2143418990","https://openalex.org/W2143551254","https://openalex.org/W2143708956","https://openalex.org/W2153877584","https://openalex.org/W2166775746","https://openalex.org/W2170275957","https://openalex.org/W2180626799","https://openalex.org/W2314225431","https://openalex.org/W2472126723","https://openalex.org/W2748101318","https://openalex.org/W4236446533","https://openalex.org/W4250855353","https://openalex.org/W4252387208"],"related_works":["https://openalex.org/W7014992485","https://openalex.org/W1911359980","https://openalex.org/W3107587415","https://openalex.org/W1558624863","https://openalex.org/W2098463105","https://openalex.org/W2153877584","https://openalex.org/W2031012964","https://openalex.org/W2091247237","https://openalex.org/W2014389921","https://openalex.org/W2035318827"],"abstract_inverted_index":{"The":[0,197],"genes":[1],"encoding":[2],"two":[3,49,54,129],"Paramecium":[4,130],"dynein":[5,31,58,134,215],"heavy":[6,32,50,135,143,201],"chains,":[7],"DHC-6":[8,20,92],"and":[9,14,26,46,132,178,181,191],"DHC-8,":[10],"have":[11],"been":[12],"cloned":[13],"sequenced.":[15],"Sequence-specific":[16],"antibodies":[17],"demonstrate":[18,82],"that":[19,83,112,141,204],"encodes":[21,28],"ciliary":[22],"outer":[23],"arm":[24],"beta-chain":[25],"DHC-8":[27],"a":[29,95,98],"cytoplasmic":[30,179],"chain.":[33],"Therefore,":[34],"this":[35,84],"study":[36],"is":[37,94,108,118,159],"the":[38,43,53,61,69,87,109,125,128,133,142,152,155,165,171,183,188,195,200,205,214,217,221],"first":[39,110],"opportunity":[40],"to":[41,105,193,212,216],"compare":[42],"primary":[44],"structures":[45],"expression":[47],"of":[48,57,65,71,91,97,101,124,127,154,170,199],"chains":[51,136],"representing":[52],"functional":[55],"classes":[56],"expressed":[59],"in":[60,68,86,103,220],"same":[62],"cell.":[63,222],"Deciliation":[64],"paramecia":[66],"results":[67],"accumulation":[70],"mRNA":[72,93],"from":[73,137],"DHC-6,":[74],"but":[75],"not":[76],"DHC-8.":[77],"Nuclear":[78],"run-on":[79],"transcription":[80,102],"experiments":[81],"increase":[85],"steady":[88],"state":[89],"concentration":[90],"consequence":[96],"rapid":[99],"induction":[100],"response":[104],"deciliation.":[106],"This":[107],"demonstration":[111],"dynein,":[113],"like":[114],"other":[115,138],"axonemal":[116,177],"components,":[117],"transcriptionally":[119],"regulated":[120],"during":[121],"reciliation.":[122],"Analyses":[123],"sequences":[126],"dyneins":[131],"organisms":[139],"indicate":[140],"chain":[144,202],"can":[145],"be":[146,210],"divided":[147],"into":[148],"three":[149],"regions:":[150],"1)":[151],"sequence":[153],"central":[156],"catalytic":[157],"domain":[158,167,208],"conserved":[160],"among":[161],"all":[162],"dyneins;":[163,180],"2)":[164],"tail":[166,207],"sequence,":[168],"consisting":[169],"N-terminal":[172,184],"1200":[173],"residues,":[174],"differentiates":[175],"between":[176],"3)":[182],"200":[185],"residues":[186],"are":[187],"most":[189],"divergent":[190],"appear":[192],"classify":[194],"isoforms.":[196],"organization":[198],"predicts":[203],"variable":[206],"may":[209],"sufficient":[211],"target":[213],"appropriate":[218],"place":[219]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}