{"id":"https://openalex.org/W1978563957","doi":"https://doi.org/10.2174/157016106776359844","title":"Fine Tuning Therapeutic Targeting of the Sphingolipid Biosynthetic Pathway to Treat Atherosclerosis","display_name":"Fine Tuning Therapeutic Targeting of the Sphingolipid Biosynthetic Pathway to Treat Atherosclerosis","publication_year":2006,"publication_date":"2006-03-28","ids":{"openalex":"https://openalex.org/W1978563957","doi":"https://doi.org/10.2174/157016106776359844","mag":"1978563957","pmid":"https://pubmed.ncbi.nlm.nih.gov/16611156"},"language":"en","primary_location":{"id":"doi:10.2174/157016106776359844","doi":"https://doi.org/10.2174/157016106776359844","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157016106776359844","pdf_url":null,"source":{"id":"https://openalex.org/S207336467","display_name":"Current Vascular Pharmacology","issn_l":"1570-1611","issn":["1570-1611","1875-6212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Vascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007722708","display_name":"Won Kim","orcid":"https://orcid.org/0000-0002-2926-1007","observed_orcids":["https://orcid.org/0000-0002-2926-1007"]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"W. Kim","raw_affiliation_strings":["Prince of Wales Medical Research Institute, Randwick, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince of Wales Medical Research Institute, Randwick, NSW, Australia","institution_ids":["https://openalex.org/I83657090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009408265","display_name":"Charles Edward Chalfant","orcid":"https://orcid.org/0000-0002-5844-5235","observed_orcids":["https://orcid.org/0000-0002-5844-5235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Chalfant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030922535","display_name":"Brett Garner","orcid":"https://orcid.org/0000-0002-5312-4352","observed_orcids":["https://orcid.org/0000-0002-5312-4352"]},"institutions":[{"id":"https://openalex.org/I83657090","display_name":"Neuroscience Research Australia","ror":"https://ror.org/01g7s6g79","country_code":"AU","type":"facility","lineage":["https://openalex.org/I83657090"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Brett Garner","raw_affiliation_strings":["Prince of Wales MedicalResearch Institute, Randwick, NSW 2031, Australia.,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince of Wales MedicalResearch Institute, Randwick, NSW 2031, Australia.,Australia","institution_ids":["https://openalex.org/I83657090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030922535"],"corresponding_institution_ids":["https://openalex.org/I83657090"],"apc_list":null,"apc_paid":null,"fwci":0.815,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67044637,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"2","first_page":"151","last_page":"154"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sphingolipid-biosynthesis","display_name":"sphingolipid biosynthesis","score":0.968999981880188},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glycosphingolipids","display_name":"glycosphingolipids","score":0.996999979019165},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.996999979019165},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":1.0},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.5609999895095825},{"id":"https://openalex.org/keywords/vascular-biology","display_name":"vascular biology","score":0.7680000066757202},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.9829471707344055},{"id":"https://openalex.org/C61322309","wikidata":"https://www.wikidata.org/wiki/Q423143","display_name":"Sphingomyelin","level":3,"score":0.9199516177177429},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.8966213464736938},{"id":"https://openalex.org/C2776931407","wikidata":"https://www.wikidata.org/wiki/Q418892","display_name":"Glycosphingolipid","level":2,"score":0.8099988698959351},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.59559565782547},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.5133287310600281},{"id":"https://openalex.org/C2781070647","wikidata":"https://www.wikidata.org/wiki/Q413230","display_name":"Sphingomyelin phosphodiesterase","level":4,"score":0.43394118547439575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41742268204689026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3812335133552551},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3808417320251465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3659307658672333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3608761131763458},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.27735885977745056},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15904322266578674},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/157016106776359844","doi":"https://doi.org/10.2174/157016106776359844","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157016106776359844","pdf_url":null,"source":{"id":"https://openalex.org/S207336467","display_name":"Current Vascular Pharmacology","issn_l":"1570-1611","issn":["1570-1611","1875-6212"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Vascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:16611156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16611156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current vascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012694457","https://openalex.org/W2168794483","https://openalex.org/W2923289796","https://openalex.org/W2118438549","https://openalex.org/W4285222455","https://openalex.org/W3159688042","https://openalex.org/W2968518240","https://openalex.org/W2167264286","https://openalex.org/W7160142748","https://openalex.org/W2890490435"],"abstract_inverted_index":{"The":[0],"accumulation":[1],"of":[2,27,57,85,108,116],"sphingolipids,":[3],"including":[4],"sphingomyelin":[5,15],"and":[6,22,55,67,73],"glycosphingolipids,":[7,65],"in":[8,37,118],"atherosclerotic":[9],"lesions":[10],"is":[11,17,23,112],"well":[12],"known.":[13],"Plasma":[14],"concentration":[16],"correlated":[18],"with":[19,40],"atherosclerosis":[20,41,96],"development":[21],"an":[24],"independent":[25],"predictor":[26],"coronary":[28],"artery":[29],"disease.":[30],"Similarly,":[31],"plasma":[32],"glycosphingolipid":[33],"levels":[34],"are":[35],"increased":[36],"conditions":[38],"associated":[39],"risk.":[42],"Recent":[43],"studies":[44],"have":[45],"focused":[46],"on":[47,78],"understanding":[48],"the":[49,58,86,99,106,113],"mechanisms":[50],"by":[51],"which":[52,111],"specific":[53],"intermediates":[54],"end-products":[56],"sphingolipid":[59,87],"biosynthetic":[60,88],"pathway,":[61],"such":[62],"as":[63],"sphingomyelin,":[64],"ceramide":[66],"sphingosine-1-phosphate":[68],"may":[69],"modulate":[70],"vascular":[71],"biology":[72],"atherosclerosis.":[74],"Here":[75],"we":[76],"focus":[77],"recent":[79],"work":[80],"indicating":[81],"that":[82],"pharmacological":[83],"modulation":[84],"pathway":[89],"could":[90],"offer":[91],"a":[92],"novel":[93],"treatment":[94],"for":[95],"or,":[97],"at":[98],"very":[100],"least,":[101],"provide":[102],"mechanistic":[103],"insights":[104],"concerning":[105],"etiology":[107],"this":[109],"disease":[110],"major":[114],"cause":[115],"death":[117],"developed":[119],"countries.":[120]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}