{"id":"https://openalex.org/W1978557940","doi":"https://doi.org/10.1159/000102912","title":"Cathepsin D Serum Levels Are Not a Valid Serum Marker in Renal Cell Carcinoma","display_name":"Cathepsin D Serum Levels Are Not a Valid Serum Marker in Renal Cell Carcinoma","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W1978557940","doi":"https://doi.org/10.1159/000102912","mag":"1978557940","pmid":"https://pubmed.ncbi.nlm.nih.gov/17627167"},"language":"en","primary_location":{"id":"doi:10.1159/000102912","doi":"https://doi.org/10.1159/000102912","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000102912","pdf_url":null,"source":{"id":"https://openalex.org/S2232815","display_name":"Urologia Internationalis","issn_l":"0042-1138","issn":["0042-1138","1423-0399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologia Internationalis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016971686","display_name":"Axel S. Merseburger","orcid":"https://orcid.org/0000-0001-6467-3931","observed_orcids":["https://orcid.org/0000-0001-6467-3931"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel S. Merseburger","raw_affiliation_strings":["Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, Germany","Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110153312","display_name":"Joerg Hennenlotter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joerg Hennenlotter","raw_affiliation_strings":["Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086583298","display_name":"Arnulf Stenzl","orcid":"https://orcid.org/0000-0003-4207-9928","observed_orcids":["https://orcid.org/0000-0003-4207-9928"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arnulf Stenzl","raw_affiliation_strings":["Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036877635","display_name":"Gundhild Beger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gundhild Beger","raw_affiliation_strings":["Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113589201","display_name":"Ludwig J. Rinnab","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ludwig Rinnab","raw_affiliation_strings":["Department of Urology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106084345","display_name":"Markus Antonius Kuczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus A. Kuczyk","raw_affiliation_strings":["Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Eberhard Karls University Tuebingen, Tuebingen, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007366580","display_name":"Rainer Kuefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Kuefer","raw_affiliation_strings":["Department of Urology, University of Ulm, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8644,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.77428934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"79","issue":"1","first_page":"41","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7540000081062317},{"id":"https://openalex.org/keywords/diagnostic-validity","display_name":"diagnostic validity","score":0.4819999933242798},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8420000076293945},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.949999988079071},{"id":"https://openalex.org/keywords/small-renal-masses","display_name":"small renal masses","score":0.7639999985694885},{"id":"https://openalex.org/keywords/preoperative-serum-levels","display_name":"preoperative serum levels","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9167331457138062},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.8128455281257629},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.513750433921814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.492397665977478},{"id":"https://openalex.org/C2781447364","wikidata":"https://www.wikidata.org/wiki/Q584992","display_name":"Tumor marker","level":3,"score":0.46929651498794556},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.46362021565437317},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43959394097328186},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.43519651889801025},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4124097526073456},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4097062349319458},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22753608226776123},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000102912","doi":"https://doi.org/10.1159/000102912","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000102912","pdf_url":null,"source":{"id":"https://openalex.org/S2232815","display_name":"Urologia Internationalis","issn_l":"0042-1138","issn":["0042-1138","1423-0399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologia Internationalis","raw_type":"journal-article"},{"id":"pmid:17627167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17627167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologia internationalis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310389","display_name":"Novartis Foundation","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W282151759","https://openalex.org/W1817657028","https://openalex.org/W1966120276","https://openalex.org/W1971588834","https://openalex.org/W1974106287","https://openalex.org/W1975705348","https://openalex.org/W2003122962","https://openalex.org/W2037565930","https://openalex.org/W2039545078","https://openalex.org/W2051922225","https://openalex.org/W2088701873","https://openalex.org/W2092389929","https://openalex.org/W2116953975","https://openalex.org/W2163206491","https://openalex.org/W2405191348"],"related_works":["https://openalex.org/W2037565930","https://openalex.org/W2085631446","https://openalex.org/W4252635502","https://openalex.org/W2460359400","https://openalex.org/W2004286703","https://openalex.org/W1491296630","https://openalex.org/W2772705718","https://openalex.org/W4395078100","https://openalex.org/W4408018990","https://openalex.org/W2083602760"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"was":[2,91,113],"the":[3,10,63,81,200,206],"aim":[4],"of":[5,13,138,148,202,208],"this":[6,170],"study":[7],"to":[8,80,146],"evaluate":[9],"serum":[11,37,42,68,87,120,155,175],"levels":[12,38,69,121,176],"cathepsin":[14],"D":[15,36,67,89,119,150,157,174,204],"(Cath":[16],"D)":[17],"as":[18,77,129],"a":[19,187],"diagnostic":[20],"tool":[21],"in":[22,29,41,95,151,161,183,205],"patients":[23,48,96,163,184],"with":[24,31,49,72,97,100,166,186],"renal":[25,189],"cell":[26],"carcinoma":[27],"(RCC)":[28],"comparison":[30],"healthy":[32,55,101,167],"volunteers.":[33,168],"METHODS:":[34],"Cath":[35,66,88,118,149,156,173,203],"were":[39,70],"measured":[40],"samples":[43],"obtained":[44],"preoperatively":[45],"from":[46],"32":[47],"histologically":[50],"confirmed":[51],"RCC":[52,98,153,162],"versus":[53],"30":[54],"individuals":[56,102],"using":[57],"an":[58],"enzyme":[59],"immunoassay.":[60],"Additionally,":[61],"for":[62],"tumor":[64,73,126,130,132],"group,":[65],"correlated":[71],"stage":[74],"and":[75,122],"grade":[76],"determined":[78],"according":[79],"2002":[82],"TNM":[83],"classification.":[84],"RESULTS:":[85],"The":[86],"concentration":[90],"not":[92,159,178],"significantly":[93],"different":[94],"compared":[99,165],"(mean":[103],"16.58":[104],"vs.":[105],"16.64":[106],"ng/ml;":[107],"p":[108],"=":[109],"0.43).":[110],"Furthermore,":[111],"there":[112],"no":[114],"significant":[115],"association":[116],"between":[117],"several":[123],"patient":[124],"or":[125,141],"characteristics":[127],"such":[128],"stage,":[131],"grade,":[133],"lymph":[134],"node":[135],"status,":[136],"presence":[137],"metastasis,":[139],"gender":[140],"age.":[142],"CONCLUSIONS:":[143],"In":[144,169],"contrast":[145],"overexpression":[147],"primary":[152],"tissue,":[154],"is":[158],"altered":[160],"when":[164],"small":[171,188],"cohort,":[172],"did":[177],"reveal":[179],"additional":[180],"clinical":[181],"information":[182],"diagnosed":[185],"mass.":[190],"Further":[191],"prospective":[192],"multicenter":[193],"studies":[194],"might":[195],"shed":[196],"more":[197],"light":[198],"on":[199],"value":[201],"diagnostics":[207],"RCC.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
