{"id":"https://openalex.org/W1978553311","doi":"https://doi.org/10.1016/s0735-1097(03)82227-1","title":"Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase in human coronary artery endothelial cells","display_name":"Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase in human coronary artery endothelial cells","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W1978553311","doi":"https://doi.org/10.1016/s0735-1097(03)82227-1","mag":"1978553311"},"language":"en","primary_location":{"id":"doi:10.1016/s0735-1097(03)82227-1","doi":"https://doi.org/10.1016/s0735-1097(03)82227-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0735-1097(03)82227-1","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0735109703822271/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0735109703822271/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057018598","display_name":"Rajat S. Barua","orcid":"https://orcid.org/0000-0002-9642-5593","observed_orcids":["https://orcid.org/0000-0002-9642-5593"]},"institutions":[{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Rajat S. Barua","raw_affiliation_strings":["Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,","institution_ids":["https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024067164","display_name":"John A. Ambrose","orcid":"https://orcid.org/0000-0002-7648-7586","observed_orcids":["https://orcid.org/0000-0002-7648-7586","https://orcid.org/0009-0004-7329-8167"]},"institutions":[{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"John A. Ambrose","raw_affiliation_strings":["Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,","institution_ids":["https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109165982","display_name":"Dhanonjoy C. Saha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dhanonjoy C. Saha","raw_affiliation_strings":["University of Athens , Athens , Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Athens , Athens , Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062351139","display_name":"Sudhesh K. Srivastava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sudhesh K. Srivastava","raw_affiliation_strings":["Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,","institution_ids":["https://openalex.org/I4210166445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041752181","display_name":"Mary C. DeVoe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Mary C. DeVoe","raw_affiliation_strings":["Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,","institution_ids":["https://openalex.org/I4210166445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112031087","display_name":"Lesley\u2010Jane Eales\u2010Reynolds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166445","display_name":"Evangelismos Hospital","ror":"https://ror.org/05q4veh78","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166445"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lesley-Jane Eales-Reynolds","raw_affiliation_strings":["Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evangelismos Hospital , Athens , Greece, Alexandra Hospital Medical School ,","institution_ids":["https://openalex.org/I4210166445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7166,"currency":"USD","value_usd":7166},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14094531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"6","first_page":"261","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8840000033378601},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.9750000238418579},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/coronary-artery-endothelial-cells","display_name":"coronary artery endothelial cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8526337146759033},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8242636919021606},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.650806725025177},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6399549245834351},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6217212677001953},{"id":"https://openalex.org/C2992676626","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Endothelial nitric oxide synthase","level":5,"score":0.6106181144714355},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6056605577468872},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.45885398983955383},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.45845311880111694},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4164380729198456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36653217673301697},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3075198531150818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2949833273887634},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20081406831741333},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.10862898826599121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08116814494132996},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.05978009104728699},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04657769203186035},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0735-1097(03)82227-1","doi":"https://doi.org/10.1016/s0735-1097(03)82227-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0735-1097(03)82227-1","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0735109703822271/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0735-1097(03)82227-1","doi":"https://doi.org/10.1016/s0735-1097(03)82227-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0735-1097(03)82227-1","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0735109703822271/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978553311.pdf","grobid_xml":"https://content.openalex.org/works/W1978553311.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076423149","https://openalex.org/W2080096206","https://openalex.org/W2066531899","https://openalex.org/W1992391313","https://openalex.org/W2059072963","https://openalex.org/W4298878776","https://openalex.org/W7099165832","https://openalex.org/W2059508527","https://openalex.org/W2111504812","https://openalex.org/W2058636709"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
