{"id":"https://openalex.org/W1978553225","doi":"https://doi.org/10.1073/pnas.0731871100","title":"Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor","display_name":"Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor","publication_year":2003,"publication_date":"2003-05-15","ids":{"openalex":"https://openalex.org/W1978553225","doi":"https://doi.org/10.1073/pnas.0731871100","mag":"1978553225","pmid":"https://pubmed.ncbi.nlm.nih.gov/12750477","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/164479"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0731871100","doi":"https://doi.org/10.1073/pnas.0731871100","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0731871100","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0731871100","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0731871100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068836103","display_name":"Saghi Ghaffari","orcid":"https://orcid.org/0000-0002-1835-6107","observed_orcids":["https://orcid.org/0000-0002-1835-6107"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saghi Ghaffari","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","Massachusetts Institute of Technology, Cambridge, MA 02139","Whitehead Institute for Biomedical Research, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076396482","display_name":"Zainab Jagani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zainab Jagani","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","Massachusetts Institute of Technology, Cambridge, MA 02139","Whitehead Institute for Biomedical Research, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028906264","display_name":"Claire Kitidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Kitidis","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","Massachusetts Institute of Technology, Cambridge, MA 02139","Whitehead Institute for Biomedical Research, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076111394","display_name":"Harvey F. Lodish","orcid":"https://orcid.org/0000-0002-7029-7415","observed_orcids":["https://orcid.org/0000-0002-7029-7415"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harvey F. Lodish","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","Massachusetts Institute of Technology, Cambridge, MA 02139","Whitehead Institute for Biomedical Research, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091416572","display_name":"Roya Khosravi\u2010Far","orcid":"https://orcid.org/0000-0003-0430-4602","observed_orcids":["https://orcid.org/0000-0003-0430-4602"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roya Khosravi-Far","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","Massachusetts Institute of Technology, Cambridge, MA 02139","Whitehead Institute for Biomedical Research, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Departments of Pathology, Beth Israel Deaconess Medical Center, and Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215; and Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068836103","https://openalex.org/A5076111394","https://openalex.org/A5076396482"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":3.017,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.92415557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"100","issue":"11","first_page":"6523","last_page":"6528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.13920000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9160000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5090000033378601},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.8199999928474426},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8370000123977661},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.9649999737739563},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":1.0},{"id":"https://openalex.org/keywords/death-receptor-signaling","display_name":"death receptor signaling","score":0.7390000224113464},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hematopoietic-cells","display_name":"hematopoietic cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6998850107192993},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6577155590057373},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6463032364845276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.573251485824585},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5723236799240112},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5388616323471069},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5083104968070984},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.504921019077301},{"id":"https://openalex.org/C2775855021","wikidata":"https://www.wikidata.org/wiki/Q968436","display_name":"Cytokine receptor","level":3,"score":0.4664117097854614},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4440954923629761},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2385692596435547},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.1876460313796997},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06229528784751892},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06211331486701965}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053221","descriptor_name":"TNF-Related Apoptosis-Inducing Ligand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0731871100","doi":"https://doi.org/10.1073/pnas.0731871100","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0731871100","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0731871100","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:164479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/164479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:12750477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12750477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.0731871100","doi":"https://doi.org/10.1073/pnas.0731871100","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.0731871100","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.0731871100","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1058160060","display_name":"Regul. of Gene Expression in Prokaryotes and Eukaryotes","funder_award_id":"T32GM007196","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4164330655","display_name":"DEVELOPMENTAL BIOLOGY OF HUMAN ERYTHROPOIESIS","funder_award_id":"P01HL032262","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4430757845","display_name":"IN VIVO SIGNALING OF THE ERYTHROPOIETIN RECEPTOR","funder_award_id":"K08CA077675","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6589656097","display_name":"TRAIL induced apoptotic pathways","funder_award_id":"R55CA087675","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000090401","display_name":"DISSECTING THE FAS SIGNALING PATHWAYS","funder_award_id":"K01CA078396","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1978553225.pdf"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1484817497","https://openalex.org/W1524354116","https://openalex.org/W1527985047","https://openalex.org/W1564768747","https://openalex.org/W1611419331","https://openalex.org/W1965286700","https://openalex.org/W1965385026","https://openalex.org/W1968525362","https://openalex.org/W1979775936","https://openalex.org/W1987335106","https://openalex.org/W2006917576","https://openalex.org/W2007530728","https://openalex.org/W2011785467","https://openalex.org/W2027843251","https://openalex.org/W2034269086","https://openalex.org/W2041440798","https://openalex.org/W2046623154","https://openalex.org/W2049312704","https://openalex.org/W2052428576","https://openalex.org/W2054278139","https://openalex.org/W2062629127","https://openalex.org/W2087877138","https://openalex.org/W2116396726","https://openalex.org/W2128659272","https://openalex.org/W2130988210","https://openalex.org/W2131924812","https://openalex.org/W2132338191","https://openalex.org/W2133726754","https://openalex.org/W2133792873","https://openalex.org/W2137035181","https://openalex.org/W2142968220","https://openalex.org/W2143562096","https://openalex.org/W2144631066","https://openalex.org/W2153787194","https://openalex.org/W2169814840","https://openalex.org/W2224782492","https://openalex.org/W2327926837","https://openalex.org/W4211030804","https://openalex.org/W4239718055","https://openalex.org/W6607149620","https://openalex.org/W6816601083"],"related_works":["https://openalex.org/W1968730099","https://openalex.org/W2145743858","https://openalex.org/W2046554377","https://openalex.org/W2073308589","https://openalex.org/W2134199670","https://openalex.org/W2057402345","https://openalex.org/W2104717299","https://openalex.org/W2071360579","https://openalex.org/W2034630122","https://openalex.org/W2065326187"],"abstract_inverted_index":{"Cytokine-provided":[0],"survival":[1],"signals":[2],"are":[3],"known":[4],"to":[5,75],"suppress":[6],"apoptosis":[7],"through":[8,95],"inhibition":[9,69,98,106],"of":[10,54,70,90,99,107],"mitochondrial":[11],"pathways":[12],"that":[13,21,33,67,85],"involve":[14],"Bcl-2":[15],"family":[16],"members.":[17],"Here":[18],"we":[19,65,83],"show":[20,66],"in":[22,41,49,110,120],"hematopoietic":[23,34,111],"cells,":[24,43,51],"cytokines":[25,35],"also":[26],"regulate":[27],"death":[28],"receptor-mediated":[29],"pathways.":[30],"We":[31],"demonstrate":[32,84],"such":[36],"as":[37,44,46],"IL-3":[38],"and":[39,87,97],"erythropoietin":[40],"normal":[42],"well":[45],"BCR-ABL":[47,88],"oncoprotein":[48],"transformed":[50],"inhibit":[52],"transcription":[53,92,103,109],"tumor":[55],"necrosis":[56],"factor-related":[57],"apoptosis-inducing":[58],"ligand":[59],"(TRAIL).":[60],"Using":[61],"small":[62],"interfering":[63],"RNAs,":[64],"the":[68,100],"TRAIL":[71,91,108],"function":[72],"is":[73,93],"sufficient":[74],"partially":[76],"rescue":[77],"cytokine-deprived":[78],"cells":[79,112],"from":[80],"apoptosis.":[81],"Finally,":[82],"cytokine":[86],"suppression":[89],"mediated":[94],"phosphorylation":[96],"forkhead":[101],"FOXO3a":[102],"factor.":[104],"BCR-ABL-induced":[105],"may":[113],"provide":[114],"a":[115],"novel":[116],"mechanism":[117],"for":[118],"tumorigenicity":[119],"chronic":[121],"myeloid":[122],"leukemia.":[123]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
