{"id":"https://openalex.org/W1978544029","doi":"https://doi.org/10.1182/blood-2002-01-0195","title":"Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse","display_name":"Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse","publication_year":2002,"publication_date":"2002-09-18","ids":{"openalex":"https://openalex.org/W1978544029","doi":"https://doi.org/10.1182/blood-2002-01-0195","mag":"1978544029","pmid":"https://pubmed.ncbi.nlm.nih.gov/12239146"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2002-01-0195","doi":"https://doi.org/10.1182/blood-2002-01-0195","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2002-01-0195","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978544029"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063094149","display_name":"Lee\u2010Yung Shih","orcid":"https://orcid.org/0000-0003-1866-7922","observed_orcids":["https://orcid.org/0000-0003-1866-7922"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lee-Yung Shih","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106134892","display_name":"Chein\u2010Fuang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chein-Fuang Huang","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110179973","display_name":"Jin\u2010Hou Wu","orcid":"https://orcid.org/0009-0003-0173-6853","observed_orcids":["https://orcid.org/0009-0003-0173-6853"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jin-Hou Wu","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067112489","display_name":"Tung\u2010Liang Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tung-Liang Lin","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113691928","display_name":"Po Dunn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po Dunn","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007141472","display_name":"Po\u2010Nan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Nan Wang","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043803592","display_name":"Ming\u2010Chung Kuo","orcid":"https://orcid.org/0000-0003-1324-5034","observed_orcids":["https://orcid.org/0000-0003-1324-5034"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Chung Kuo","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043432088","display_name":"Chang\u2010Liang Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chang-Liang Lai","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hui-Chin Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Chin Hsu","raw_affiliation_strings":["From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, and Chang Gung University, Taipei, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":8.1082,"has_fulltext":false,"cited_by_count":310,"citation_normalized_percentile":{"value":0.9803851,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"100","issue":"7","first_page":"2387","last_page":"2392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.9399999976158142},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.7850000262260437},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.574999988079071},{"id":"https://openalex.org/keywords/hemizygous-deletion","display_name":"hemizygous deletion","score":0.7239999771118164},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.7680000066757202},{"id":"https://openalex.org/keywords/leukemic-transformation","display_name":"leukemic transformation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.7110297679901123},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.649721622467041},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.6056409478187561},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5834089517593384},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.554848313331604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5255388617515564},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4780184030532837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47288885712623596},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4282609522342682},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4229468107223511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33262091875076294},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33219021558761597},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33085599541664124},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32349783182144165},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1164671778678894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08066394925117493}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001752","descriptor_name":"Blast Crisis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2002-01-0195","doi":"https://doi.org/10.1182/blood-2002-01-0195","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2002-01-0195","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:12239146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12239146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W148052780","https://openalex.org/W1533510727","https://openalex.org/W1542395305","https://openalex.org/W1592701464","https://openalex.org/W1935726541","https://openalex.org/W1968306285","https://openalex.org/W1989604472","https://openalex.org/W1990030298","https://openalex.org/W2012495613","https://openalex.org/W2017247060","https://openalex.org/W2027942293","https://openalex.org/W2034820298","https://openalex.org/W2040521097","https://openalex.org/W2040950977","https://openalex.org/W2067020831","https://openalex.org/W2078481381","https://openalex.org/W2086404440","https://openalex.org/W2095013649","https://openalex.org/W2097583774","https://openalex.org/W2112909513","https://openalex.org/W2125676392","https://openalex.org/W2129615499","https://openalex.org/W2130864403","https://openalex.org/W2147213204","https://openalex.org/W2150113701","https://openalex.org/W2239688246","https://openalex.org/W2253167439","https://openalex.org/W2275521486","https://openalex.org/W2321946412","https://openalex.org/W2323281839","https://openalex.org/W2338753933","https://openalex.org/W2339359539","https://openalex.org/W2345660383","https://openalex.org/W2464303658","https://openalex.org/W2471434467","https://openalex.org/W4285719527","https://openalex.org/W6635345608","https://openalex.org/W6640232154","https://openalex.org/W6674887746","https://openalex.org/W6678850949"],"related_works":["https://openalex.org/W2093686057","https://openalex.org/W1974214215","https://openalex.org/W604792610","https://openalex.org/W3012105465","https://openalex.org/W1991315992","https://openalex.org/W2047398950","https://openalex.org/W2105434446","https://openalex.org/W2185409657","https://openalex.org/W2028988847","https://openalex.org/W2404663151"],"abstract_inverted_index":{"Analysis":[0],"of":[1,5,34,128,144,194,202,228,234],"internal":[2],"tandem":[3],"duplications":[4],"FLT3":[6,44,130],"(FLT3/ITD)":[7],"was":[8,131],"performed":[9],"on":[10],"bone":[11],"marrow":[12],"samples":[13],"obtained":[14],"at":[15,45,53,67,77,85,104,120,136,141,152,168,177,184],"diagnosis":[16,47,86,109,153,169],"and":[17,48,62,175,220,226],"relapse":[18,79,105,137,190,221],"from":[19],"108":[20],"adult":[21],"patients":[22,41,135,147,161],"with":[23,108,113,155,162],"de":[24],"novo":[25],"acute":[26],"myeloid":[27],"leukemia":[28],"(AML)":[29],"to":[30,139],"determine":[31],"the":[32,60,114,145,189,200,214,224],"role":[33],"this":[35,239],"mutation":[36,61,102,151,167,173,187,195],"in":[37,101,116,133,172,188,218],"leukemic":[38],"relapse.":[39,68],"Eighty-three":[40],"had":[42,51,58,64,197],"wild-type":[43,129],"both":[46,54,121],"relapse,":[49],"16":[50],"FLT3/ITD":[52,75,166,210],"stages,":[55],"whereas":[56],"8":[57],"acquired":[59],"1":[63],"lost":[65],"it":[66],"Using":[69],"Genescan":[70],"analysis,":[71],"we":[72],"found":[73,132],"that":[74,209],"levels":[76,103,176],"first":[78,178],"were":[80],"significantly":[81],"higher":[82],"than":[83,164],"those":[84],"(mean":[87],"+/-":[88,91,95],"SE,":[89],"40.5%":[90],"4.8%":[92],"versus":[93],"17.9%":[94],"3.6%,":[96],"P":[97],"<.001).":[98],"The":[99,192],"increase":[100],"as":[106,213],"compared":[107,138],"did":[110],"not":[111],"correlate":[112],"difference":[115],"blast":[117],"cell":[118],"percentages":[119],"stages":[122],"(P":[123],"=.777).":[124],"A":[125],"hemizygous":[126],"deletion":[127],"4":[134],"none":[140],"diagnosis.":[142],"Nine":[143],"11":[146],"carrying":[148],"a":[149,229,235],"single":[150],"relapsed":[154],"an":[156],"identical":[157],"mutation.":[158,240],"All":[159],"6":[160],"more":[163],"one":[165,186],"showed":[170],"changes":[171,193],"patterns":[174,196],"relapse;":[179],"however,":[180],"each":[181],"patient":[182],"retained":[183],"least":[185],"sample.":[191],"implications":[198],"for":[199],"monitoring":[201],"minimal":[203],"residual":[204],"disease.":[205],"Our":[206],"results":[207],"suggest":[208],"may":[211],"contribute":[212],"initial":[215],"transforming":[216],"event":[217],"AML,":[219],"can":[222],"reflect":[223],"selection":[225],"outgrowth":[227],"mutant":[230],"clone":[231,237],"or":[232],"evolution":[233],"new":[236],"harboring":[238]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}