{"id":"https://openalex.org/W1978536616","doi":"https://doi.org/10.3791/2142-v","title":"Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation","display_name":"Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation","publication_year":2010,"publication_date":"2010-09-07","ids":{"openalex":"https://openalex.org/W1978536616","doi":"https://doi.org/10.3791/2142-v","mag":"1978536616","pmid":"https://pubmed.ncbi.nlm.nih.gov/20864924","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3157878"},"language":"en","primary_location":{"id":"doi:10.3791/2142-v","doi":"https://doi.org/10.3791/2142-v","is_oa":false,"landing_page_url":"https://doi.org/10.3791/2142-v","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jove.com/pdf/2142/detection-neu1-sialidase-activity-regulating-toll-like-receptor","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084198134","display_name":"Schammim Ray Amith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Schammim R. Amith","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University-Kingston, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University-Kingston, Ontario","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634142","display_name":"Preethi Jayanth","orcid":"https://orcid.org/0000-0001-9209-7900","observed_orcids":["https://orcid.org/0000-0001-9209-7900"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Preethi Jayanth","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University - Kingston, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University - Kingston, Ontario","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041277348","display_name":"Trisha M. Finlay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Trisha Finlay","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University - Kingston, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University - Kingston, Ontario","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017944263","display_name":"Susan L. Franchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Susan Franchuk","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University - Kingston, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University - Kingston, Ontario","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044583685","display_name":"Alanna M. Gilmour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alanna Gilmour","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University - Kingston, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University - Kingston, Ontario","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075156484","display_name":"Samar Abdulkhalek","orcid":"https://orcid.org/0000-0002-2527-3406","observed_orcids":["https://orcid.org/0000-0002-2527-3406"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Samar Abdulkhalek","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University - Kingston, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University - Kingston, Ontario","institution_ids":["https://openalex.org/I204722609"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053078335","display_name":"Myron R. Szewczuk","orcid":"https://orcid.org/0000-0001-8471-5481","observed_orcids":["https://orcid.org/0000-0001-8471-5481"]},"institutions":[{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Myron R. Szewczuk","raw_affiliation_strings":["Department of Microbiology and Immunology, Queen's University - Kingston, Ontario"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Queen's University - Kingston, Ontario","institution_ids":["https://openalex.org/I204722609"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204722609"],"apc_list":null,"apc_paid":null,"fwci":1.0281,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.73382602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":"43","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9077000021934509,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptor-activation","display_name":"Toll-like receptor activation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sialic-acid-glycosylation","display_name":"sialic acid glycosylation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/ligand-induced-receptor-activation","display_name":"ligand-induced receptor activation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.6579999923706055},{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/trka","display_name":"TrkA","score":0.48399999737739563},{"id":"https://openalex.org/keywords/trkb","display_name":"TrkB","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9440000057220459},{"id":"https://openalex.org/keywords/thymoquinone","display_name":"thymoquinone","score":0.8790000081062317},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7369999885559082},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C73695083","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Sialidase","level":4,"score":0.8560853600502014},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.6078395843505859},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5455796122550964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5199264883995056},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41989535093307495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3275088667869568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2391379475593567},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13359680771827698},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.12574338912963867},{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.12443602085113525}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009439","descriptor_name":"Neuraminidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3791/2142-v","doi":"https://doi.org/10.3791/2142-v","is_oa":false,"landing_page_url":"https://doi.org/10.3791/2142-v","pdf_url":null,"source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"doi:10.3791/2142","doi":"https://doi.org/10.3791/2142","is_oa":true,"landing_page_url":"https://doi.org/10.3791/2142","pdf_url":"https://www.jove.com/pdf/2142/detection-neu1-sialidase-activity-regulating-toll-like-receptor","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2438886","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3157878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:20864924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20864924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of visualized experiments : JoVE","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3157878","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3157878/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Vis Exp","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3791/2142","doi":"https://doi.org/10.3791/2142","is_oa":true,"landing_page_url":"https://doi.org/10.3791/2142","pdf_url":"https://www.jove.com/pdf/2142/detection-neu1-sialidase-activity-regulating-toll-like-receptor","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321832","display_name":"Queen's University","ror":"https://ror.org/02y72wh86"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978536616.pdf","grobid_xml":"https://content.openalex.org/works/W1978536616.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1970087902","https://openalex.org/W1973336970","https://openalex.org/W1989569828","https://openalex.org/W2043919610","https://openalex.org/W2081500546","https://openalex.org/W2147143140"],"related_works":["https://openalex.org/W1989569828","https://openalex.org/W2066730813","https://openalex.org/W1970087902","https://openalex.org/W2499167872","https://openalex.org/W2519298775","https://openalex.org/W2159297309","https://openalex.org/W2590366997","https://openalex.org/W4235746762","https://openalex.org/W2083172582","https://openalex.org/W7099946851"],"abstract_inverted_index":{"Mammalian":[0],"Toll-like":[1],"receptors":[2,8,162,319],"(TLRs)":[3],"are":[4,16,103],"a":[5,124,189,273,329],"family":[6],"of":[7,20,37,52,69,100,127,196,203,302,316],"that":[9,64,142,157,222],"recognize":[10],"pathogen-associated":[11],"molecular":[12,300],"patterns.":[13],"Not":[14],"only":[15],"TLRs":[17],"crucial":[18],"sensors":[19,102,112],"microbial":[21],"(e.g.,":[22],"viruses,":[23],"bacteria":[24],"and":[25,42,50,75,113,165,170,207,214,232,235,268,313],"parasite)":[26],"infections,":[27],"they":[28],"also":[29,86,155],"play":[30],"an":[31],"important":[32,88],"role":[33],"in":[34,44,175,193,227,284],"the":[35,48,66,97,106,111,178,194,200,289,299,307,314],"pathophysiology":[36],"infectious":[38,56],"diseases,":[39,41],"inflammatory":[40],"possibly":[43],"autoimmune":[45],"diseases.":[46],"Thus,":[47],"intensity":[49],"duration":[51],"TLR":[53,101,128,144,217],"responses":[54],"against":[55],"diseases":[57],"must":[58],"be":[59,323],"tightly":[60,147,159],"controlled.":[61],"It":[62,84,140],"follows":[63],"understanding":[65],"structural":[67],"integrity":[68],"sensor":[70,94],"receptors,":[71,218,234],"their":[72,114],"ligand":[73,239,254],"interactions":[74,109],"signaling":[76,98],"components":[77],"is":[78,146,225,236],"essential":[79],"for":[80,90],"subsequent":[81],"immunological":[82],"protection.":[83],"would":[85,327],"provide":[87],"opportunities":[89],"disease":[91],"modification":[92],"through":[93],"manipulation.":[95],"Although":[96,306],"pathways":[99],"well":[104],"characterized,":[105],"parameters":[107],"controlling":[108],"between":[110,310],"ligands":[115],"still":[116],"remain":[117],"poorly":[118],"defined.":[119],"We":[120,153],"have":[121,154],"recently":[122],"identified":[123],"novel":[125,190],"mechanism":[126],"activation":[129,145,195,267,315],"by":[130,149],"its":[131],"natural":[132],"ligand,":[133,191],"which":[134,167],"has":[135,183,278,292,320],"not":[136],"been":[137,184,279],"previously":[138],"observed.":[139],"suggests":[141],"ligand-induced":[143,303],"controlled":[148],"Neu1":[150,158,169,223,245,276,311],"sialidase":[151,181,198,224,246,277,290,312],"activation.":[152,305],"reported":[156],"regulates":[160],"neurotrophin":[161],"like":[163],"TrkA":[164],"TrkB,":[166],"involve":[168],"matrix":[171],"metalloproteinase-9":[172],"(MMP-9)":[173],"cross-talk":[174],"complex":[176,228,264],"with":[177,229,295],"receptors.":[179],"The":[180],"assay":[182,291],"initially":[185],"use":[186],"to":[187,241,256,260,281,298,322,334],"find":[188],"thymoquinone,":[192],"Neu4":[197],"on":[199],"cell":[201,270,335],"surface":[202],"macrophages,":[204],"dendritic":[205],"cells":[206,209],"fibroblast":[208],"via":[210],"GPCR":[211],"G\u03b1i":[212],"proteins":[213],"MMP-9.":[215],"For":[216],"our":[219],"data":[220],"indicate":[221],"already":[226],"TLR-2,":[230],"-3":[231],"-4":[233],"induced":[237],"upon":[238],"binding":[240,255],"either":[242],"receptor.":[243],"Activated":[244],"hydrolyzes":[247],"sialyl":[248],"\u03b1-2,3-linked":[249],"\u03b2-galactosyl":[250],"residues":[251],"distant":[252],"from":[253],"remove":[257],"steric":[258],"hinderance":[259],"TLR-4":[261],"dimerization,":[262],"MyD88/TLR4":[263],"recruitment,":[265],"NFkB":[266],"pro-inflammatory":[269],"responses.":[271],"In":[272],"collaborative":[274],"report,":[275],"shown":[280],"regulate":[282],"phagocytosis":[283],"macrophage":[285],"cells.":[286],"Taken":[287],"together,":[288],"provided":[293],"us":[294],"powerful":[296],"insights":[297],"mechanisms":[301],"receptor":[304],"precise":[308],"relationship":[309],"TLR,":[317],"Trk":[318],"yet":[321],"fully":[324],"elucidated,":[325],"it":[326],"represent":[328],"new":[330],"or":[331],"pioneering":[332],"approach":[333],"regulation":[336],"pathways.":[337]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
