{"id":"https://openalex.org/W1978527260","doi":"https://doi.org/10.1523/jneurosci.1284-12.2012","title":"Genetic Ablation of Hypocretin Neurons Alters Behavioral State Transitions in Zebrafish","display_name":"Genetic Ablation of Hypocretin Neurons Alters Behavioral State Transitions in Zebrafish","publication_year":2012,"publication_date":"2012-09-12","ids":{"openalex":"https://openalex.org/W1978527260","doi":"https://doi.org/10.1523/jneurosci.1284-12.2012","mag":"1978527260","pmid":"https://pubmed.ncbi.nlm.nih.gov/22973020","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6703801"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.1284-12.2012","doi":"https://doi.org/10.1523/jneurosci.1284-12.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1284-12.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/37/12961.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/32/37/12961.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039137771","display_name":"Idan Elbaz","orcid":"https://orcid.org/0009-0008-6613-8850","observed_orcids":["https://orcid.org/0009-0008-6613-8850"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Idan Elbaz","raw_affiliation_strings":["The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","1The Mina and Everard Goodman Faculty of Life Sciences and","2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"1The Mina and Everard Goodman Faculty of Life Sciences and","institution_ids":[]},{"raw_affiliation_string":"2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005031775","display_name":"Laura Yelin\u2010Bekerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Laura Yelin-Bekerman","raw_affiliation_strings":["1The Mina and Everard Goodman Faculty of Life Sciences and","2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Mina and Everard Goodman Faculty of Life Sciences and","institution_ids":[]},{"raw_affiliation_string":"2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054634948","display_name":"Julian Nicenboim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Julian Nicenboim","raw_affiliation_strings":["3Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080629208","display_name":"Gad David Vatine","orcid":"https://orcid.org/0000-0003-3674-1671","observed_orcids":["https://orcid.org/0000-0003-3674-1671"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gad Vatine","raw_affiliation_strings":["1The Mina and Everard Goodman Faculty of Life Sciences and","2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Mina and Everard Goodman Faculty of Life Sciences and","institution_ids":[]},{"raw_affiliation_string":"2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027650124","display_name":"Lior Appelbaum","orcid":"https://orcid.org/0000-0002-9248-5919","observed_orcids":["https://orcid.org/0000-0002-9248-5919"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lior Appelbaum","raw_affiliation_strings":["1The Mina and Everard Goodman Faculty of Life Sciences and","2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Mina and Everard Goodman Faculty of Life Sciences and","institution_ids":[]},{"raw_affiliation_string":"2The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel, and","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4375,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.92023346,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"32","issue":"37","first_page":"12961","last_page":"12972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypocretin-neurons","display_name":"hypocretin neurons","score":0.8569999933242798},{"id":"https://openalex.org/keywords/orexin","display_name":"orexin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/narcolepsy","display_name":"narcolepsy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/sleep-wake-transition","display_name":"sleep-wake transition","score":0.8730000257492065},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7680000066757202},{"id":"https://openalex.org/keywords/neuronal-ablation","display_name":"neuronal ablation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sleep-regulation","display_name":"sleep regulation","score":0.5569999814033508},{"id":"https://openalex.org/keywords/behavioral-state-transitions","display_name":"behavioral state transitions","score":0.6729999780654907},{"id":"https://openalex.org/keywords/c-fos-expression","display_name":"Fos expression","score":0.8399999737739563},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.8385308384895325},{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.8208190202713013},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5995936393737793},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5802363753318787},{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.5114394426345825},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.4997215270996094},{"id":"https://openalex.org/C2780714764","wikidata":"https://www.wikidata.org/wiki/Q17125841","display_name":"Lateral hypothalamus","level":3,"score":0.49560868740081787},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.45147836208343506},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43173930048942566},{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.4142433702945709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4102059006690979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35954421758651733},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3586796522140503},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.34317338466644287},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24473634362220764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24051529169082642},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.19753530621528625},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.18568503856658936},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.0903765857219696},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.06829434633255005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068797","descriptor_name":"Orexins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009290","descriptor_name":"Narcolepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.1284-12.2012","doi":"https://doi.org/10.1523/jneurosci.1284-12.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1284-12.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/37/12961.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6703801","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6703801","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:22973020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22973020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.1284-12.2012","doi":"https://doi.org/10.1523/jneurosci.1284-12.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.1284-12.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/37/12961.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2501881954","display_name":"The role of rhythmic synaptic plasticity in regulating sleep and behavioral performance","funder_award_id":"274333","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321449","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978527260.pdf","grobid_xml":"https://content.openalex.org/works/W1978527260.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W114379953","https://openalex.org/W197495535","https://openalex.org/W602058447","https://openalex.org/W1499260848","https://openalex.org/W1518006357","https://openalex.org/W1519232679","https://openalex.org/W1627229807","https://openalex.org/W1900979097","https://openalex.org/W1967803100","https://openalex.org/W1971566808","https://openalex.org/W1977235352","https://openalex.org/W1977320288","https://openalex.org/W1983109395","https://openalex.org/W1992895646","https://openalex.org/W1996214950","https://openalex.org/W1998101177","https://openalex.org/W1998595216","https://openalex.org/W1999919528","https://openalex.org/W2000524884","https://openalex.org/W2002293846","https://openalex.org/W2020607530","https://openalex.org/W2027740042","https://openalex.org/W2032389394","https://openalex.org/W2034261913","https://openalex.org/W2035772592","https://openalex.org/W2043864709","https://openalex.org/W2045003633","https://openalex.org/W2046584597","https://openalex.org/W2049197563","https://openalex.org/W2050467552","https://openalex.org/W2056213320","https://openalex.org/W2057101237","https://openalex.org/W2063210874","https://openalex.org/W2064935594","https://openalex.org/W2072154498","https://openalex.org/W2072386549","https://openalex.org/W2072681733","https://openalex.org/W2079636816","https://openalex.org/W2082692578","https://openalex.org/W2084252683","https://openalex.org/W2084556601","https://openalex.org/W2096109037","https://openalex.org/W2098171698","https://openalex.org/W2114570899","https://openalex.org/W2129357751","https://openalex.org/W2132962760","https://openalex.org/W2134943302","https://openalex.org/W2139258495","https://openalex.org/W2139798412","https://openalex.org/W2149954185","https://openalex.org/W2150515709","https://openalex.org/W2152211310","https://openalex.org/W2154387759","https://openalex.org/W2159953069","https://openalex.org/W2169378022","https://openalex.org/W2488532189"],"related_works":["https://openalex.org/W2560898680","https://openalex.org/W2032389394","https://openalex.org/W4405943328","https://openalex.org/W2045003633","https://openalex.org/W2606008791","https://openalex.org/W2063210874","https://openalex.org/W1996214950","https://openalex.org/W2623907399","https://openalex.org/W7100844384","https://openalex.org/W2556864667"],"abstract_inverted_index":{"Sleep":[0],"is":[1,16,29,59],"an":[2,117,126,176],"essential":[3],"biological":[4],"need":[5],"of":[6,23,34,54,76,87,93,99,129,152,171,192,217,222,237],"all":[7],"animals":[8,82],"studied":[9],"to":[10,83,159,163,247],"date.":[11],"The":[12,52],"sleep":[13,63,120,138,141],"disorder":[14],"narcolepsy":[15],"characterized":[17],"by":[18,31],"excessive":[19],"daytime":[20],"sleepiness,":[21],"fragmentation":[22],"nighttime":[24],"sleep,":[25],"and":[26,50,64,79,90,125,135,142,213,228],"cataplexy.":[27],"Narcolepsy":[28],"caused":[30],"selective":[32],"degeneration":[33],"hypothalamic":[35],"hypocretin/orexin":[36],"(HCRT)":[37],"neurons.":[38],"In":[39],"mammals,":[40],"HCRT":[41,55,77,88,94,101,108,147,153,180,197,218,238],"neurons":[42,56,78,89,95,154,219,239],"primarily":[43],"regulate":[44],"the":[45,85,97,100,123,156,166,186,189],"sleep/wake":[46,130,223],"cycle,":[47],"feeding,":[48],"reward-seeking,":[49],"addiction.":[51],"role":[53,216,236],"in":[57,61,119,146,179,220,240,245],"zebrafish":[58,71,207],"implicated":[60],"both":[62,133,226],"wake":[65],"regulation.":[66],"We":[67],"established":[68],"a":[69,201,209,215,234],"transgenic":[70],"model":[72,210],"enabling":[73],"inducible":[74],"ablation":[75,151],"used":[80],"these":[81],"understand":[84],"function":[86],"narcolepsy.":[91],"Loss":[92],"increased":[96,127,143],"expression":[98,145],"receptor":[102],"(hcrtr).":[103],"Behavioral":[104],"assays":[105],"revealed":[106],"that":[107],"neuron-ablated":[109,148,181,198],"larvae":[110,199],"had":[111],"normal":[112],"locomotor":[113,169,190],"activity,":[114],"but":[115,174],"demonstrated":[116,200],"increase":[118],"time":[121],"during":[122,132,165,185,225],"day":[124,134,187,227],"number":[128],"transitions":[131,224,244],"night.":[136,229],"Mild":[137],"disturbance":[139],"reduced":[140,188],"c-fos":[144],"larvae.":[149,182],"Furthermore,":[150],"altered":[155],"behavioral":[157,242],"response":[158,178,246],"external":[160,248],"stimuli.":[161,249],"Exposure":[162],"light":[164],"night":[167],"decreased":[168],"activity":[170,191],"wild-type":[172,193],"siblings,":[173],"induced":[175],"opposite":[177],"Sound":[183],"stimulus":[184],"sibling":[194],"larvae,":[195],"while":[196],"hyposensitive":[202],"response.":[203],"This":[204],"study":[205],"establishes":[206],"as":[208],"for":[211],"narcolepsy,":[212],"indicating":[214],"regulation":[221],"Our":[230],"results":[231],"further":[232],"suggest":[233],"key":[235],"mediating":[241],"state":[243]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
