{"id":"https://openalex.org/W1978525638","doi":"https://doi.org/10.1523/jneurosci.2989-11.2011","title":"Chronic 5-HT Transporter Blockade Reduces DA Signaling to Elicit Basal Ganglia Dysfunction","display_name":"Chronic 5-HT Transporter Blockade Reduces DA Signaling to Elicit Basal Ganglia Dysfunction","publication_year":2011,"publication_date":"2011-11-02","ids":{"openalex":"https://openalex.org/W1978525638","doi":"https://doi.org/10.1523/jneurosci.2989-11.2011","mag":"1978525638","pmid":"https://pubmed.ncbi.nlm.nih.gov/22049417","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3758550"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2989-11.2011","doi":"https://doi.org/10.1523/jneurosci.2989-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2989-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/44/15742.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/31/44/15742.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063945951","display_name":"Emanuela Morelli","orcid":"https://orcid.org/0000-0001-8704-9330","observed_orcids":["https://orcid.org/0000-0001-8704-9330"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuela Morelli","raw_affiliation_strings":["Division of Developmental Neuroscience, Department of Psychiatry, Columbia University, New York, New York 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Developmental Neuroscience, Department of Psychiatry, Columbia University, New York, New York 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036878613","display_name":"Holly M Moore","orcid":"https://orcid.org/0009-0001-7320-6347","observed_orcids":["https://orcid.org/0009-0001-7320-6347"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly Moore","raw_affiliation_strings":["Integrative Neuroscience, Department of Psychiatry, Columbia University, New York, New York 10032 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Neuroscience, Department of Psychiatry, Columbia University, New York, New York 10032 and","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108636694","display_name":"Tahilia J. Rebello","orcid":"https://orcid.org/0000-0003-1918-3225","observed_orcids":["https://orcid.org/0000-0003-1918-3225"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tahilia J. Rebello","raw_affiliation_strings":["Divisions of Developmental Neuroscience and","Developmental Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Developmental Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Developmental Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Neil Gray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil Gray","raw_affiliation_strings":["Divisions of Developmental Neuroscience and","Developmental Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Developmental Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Developmental Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051290218","display_name":"Kelly N. Steele","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly Steele","raw_affiliation_strings":["Divisions of Developmental Neuroscience and","Developmental Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Developmental Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Developmental Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104062079","display_name":"Ennio Esposito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ennio Esposito","raw_affiliation_strings":["Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013653469","display_name":"Jay A. Gingrich","orcid":"https://orcid.org/0000-0002-7890-0389","observed_orcids":["https://orcid.org/0000-0002-7890-0389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay A. Gingrich","raw_affiliation_strings":["Divisions of Developmental Neuroscience and","Developmental Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Developmental Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Developmental Neuroscience and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018394581","display_name":"Mark S. Ansorge","orcid":"https://orcid.org/0000-0002-1467-0107","observed_orcids":["https://orcid.org/0000-0002-1467-0107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark S. Ansorge","raw_affiliation_strings":["Divisions of Developmental Neuroscience and","Developmental Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Developmental Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Developmental Neuroscience and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1196,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.85064978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"44","first_page":"15742","last_page":"15750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.6940000057220459},{"id":"https://openalex.org/keywords/5-ht-reuptake-inhibitors","display_name":"5-HT reuptake inhibitors","score":0.7910000085830688},{"id":"https://openalex.org/keywords/dopaminergic-neurotransmission","display_name":"dopamine signaling","score":0.5879999995231628},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8420000076293945},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5839999914169312},{"id":"https://openalex.org/keywords/l-dopa","display_name":"L-DOPA","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dopamine-serotonin-interaction","display_name":"serotonin-dopamine interaction","score":0.6430000066757202},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.7514797449111938},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6572089195251465},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5468816161155701},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5247122049331665},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5010831356048584},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3560739755630493},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3437165915966034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30422553420066833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2878962755203247},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2537640333175659},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2309512495994568},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21498322486877441},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.16892525553703308},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09451177716255188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06703844666481018},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001479","descriptor_name":"Basal Ganglia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005106","descriptor_name":"Exploratory Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009069","descriptor_name":"Movement Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009069","descriptor_name":"Movement Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009069","descriptor_name":"Movement Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015259","descriptor_name":"Dopamine Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045442","descriptor_name":"Rotarod Performance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1523/jneurosci.2989-11.2011","doi":"https://doi.org/10.1523/jneurosci.2989-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2989-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/44/15742.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2766570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3758550","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3758550","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3758550","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:22049417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22049417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2989-11.2011","doi":"https://doi.org/10.1523/jneurosci.2989-11.2011","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2989-11.2011","pdf_url":"https://www.jneurosci.org/content/jneuro/31/44/15742.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8424620726","display_name":"Serotonergic Modulation of Brain Development:  Genetic and Pharmacologic Influenc","funder_award_id":"P50MH090966","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978525638.pdf","grobid_xml":"https://content.openalex.org/works/W1978525638.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W159677714","https://openalex.org/W576424897","https://openalex.org/W1504665000","https://openalex.org/W1747295370","https://openalex.org/W1776942521","https://openalex.org/W1787588990","https://openalex.org/W1871888125","https://openalex.org/W1969600901","https://openalex.org/W1971764800","https://openalex.org/W1971797700","https://openalex.org/W1974426236","https://openalex.org/W1984112731","https://openalex.org/W1985020104","https://openalex.org/W1986637546","https://openalex.org/W1988184733","https://openalex.org/W1991155688","https://openalex.org/W1995006301","https://openalex.org/W1996673522","https://openalex.org/W1999238614","https://openalex.org/W2011812102","https://openalex.org/W2015205234","https://openalex.org/W2017153246","https://openalex.org/W2023057624","https://openalex.org/W2023657614","https://openalex.org/W2032627096","https://openalex.org/W2034568028","https://openalex.org/W2038771513","https://openalex.org/W2058708520","https://openalex.org/W2061149047","https://openalex.org/W2067866417","https://openalex.org/W2075085390","https://openalex.org/W2076270748","https://openalex.org/W2078153368","https://openalex.org/W2078392373","https://openalex.org/W2100876024","https://openalex.org/W2103398163","https://openalex.org/W2104431145","https://openalex.org/W2107177274","https://openalex.org/W2107522917","https://openalex.org/W2110176332","https://openalex.org/W2111405228","https://openalex.org/W2126349398","https://openalex.org/W2132324173","https://openalex.org/W2133847377","https://openalex.org/W2141716990","https://openalex.org/W2142401824","https://openalex.org/W2142732083","https://openalex.org/W2149885167","https://openalex.org/W2150857753","https://openalex.org/W2150997715","https://openalex.org/W2154591789","https://openalex.org/W2165982554","https://openalex.org/W2168092251","https://openalex.org/W4231169313"],"related_works":["https://openalex.org/W2886279389","https://openalex.org/W1547157492","https://openalex.org/W4253437107","https://openalex.org/W2078617732","https://openalex.org/W1993889760","https://openalex.org/W2970686919","https://openalex.org/W2053758553","https://openalex.org/W7095546653","https://openalex.org/W2113933825","https://openalex.org/W1970461857"],"abstract_inverted_index":{"Serotonin":[0],"(5-HT)-selective":[1],"reuptake":[2],"inhibitors":[3],"(SSRIs)":[4],"are":[5,21],"widely":[6],"administered":[7],"for":[8],"the":[9,97],"treatment":[10],"of":[11,99,110,120],"depression,":[12],"anxiety,":[13],"and":[14,23,68,80,89,117],"other":[15],"neuropsychiatric":[16],"disorders,":[17],"but":[18,39,57],"response":[19],"rates":[20],"low,":[22],"side":[24,115],"effects":[25,116],"often":[26],"lead":[27],"to":[28],"discontinuation.":[29],"Side":[30],"effect":[31],"profiles":[32],"suggest":[33,107],"that":[34,47,108],"SSRIs":[35],"inhibit":[36],"dopaminergic":[37],"activity,":[38],"mechanistic":[40],"insight":[41],"remains":[42],"scarce.":[43],"Here":[44],"we":[45],"show":[46],"in":[48,65],"mice,":[49],"chronic":[50,72],"5-HT":[51],"transporter":[52],"(5-HTT)":[53],"blockade":[54,74],"during":[55,59],"adulthood":[56],"not":[58],"development":[60],"impairs":[61],"basal":[62,91],"ganglia-dependent":[63,92],"behaviors":[64],"a":[66],"dose-dependent":[67],"reversible":[69],"fashion.":[70],"Furthermore,":[71],"5-HTT":[73],"reduces":[75],"striatal":[76],"dopamine":[77],"(DA)":[78],"content":[79],"metabolism.":[81],"A":[82],"causal":[83],"relationship":[84],"between":[85],"reduced":[86],"DA":[87,111],"signaling":[88,112],"impaired":[90],"behavior":[93],"is":[94],"indicated":[95],"by":[96],"reversal":[98],"behavioral":[100],"deficits":[101],"through":[102],"L-DOPA":[103],"administration.":[104],"Our":[105],"data":[106],"augmentation":[109],"would":[113],"reduce":[114],"increase":[118],"efficacies":[119],"SSRI-based":[121],"therapy.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
