{"id":"https://openalex.org/W1978520575","doi":"https://doi.org/10.1038/nn1963","title":"Different roles of ribbon-associated and ribbon-free active zones in retinal bipolar cells","display_name":"Different roles of ribbon-associated and ribbon-free active zones in retinal bipolar cells","publication_year":2007,"publication_date":"2007-09-09","ids":{"openalex":"https://openalex.org/W1978520575","doi":"https://doi.org/10.1038/nn1963","mag":"1978520575","pmid":"https://pubmed.ncbi.nlm.nih.gov/17828257"},"language":"en","primary_location":{"id":"doi:10.1038/nn1963","doi":"https://doi.org/10.1038/nn1963","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nn1963","pdf_url":null,"source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070545136","display_name":"Mitsuharu Midorikawa","orcid":"https://orcid.org/0000-0003-4818-6986","observed_orcids":["https://orcid.org/0000-0003-4818-6986"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuharu Midorikawa","raw_affiliation_strings":["Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033 Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542259","display_name":"Yoshihiko Tsukamoto","orcid":"https://orcid.org/0009-0001-2560-7832","observed_orcids":["https://orcid.org/0009-0001-2560-7832"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Tsukamoto","raw_affiliation_strings":["Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, 663-8501, Japan","Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]},{"raw_affiliation_string":"Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031949763","display_name":"Ken Berglund","orcid":"https://orcid.org/0000-0003-4341-0838","observed_orcids":["https://orcid.org/0000-0003-4341-0838"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ken Berglund","raw_affiliation_strings":["Department of Neurobiology, Duke University Medical Center, Durham, 27710, North Carolina, USA","Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan","Department of Neurobiology, Duke University Medical Center, Durham, USA","Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center, Durham, 27710, North Carolina, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Neurobiology, Duke University Medical Center, Durham, USA","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061474397","display_name":"Masaaki Ishii","orcid":"https://orcid.org/0000-0002-0775-5401","observed_orcids":["https://orcid.org/0000-0002-0775-5401"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaaki Ishii","raw_affiliation_strings":["Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, 663-8501, Japan","Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]},{"raw_affiliation_string":"Department of Biology, Hyogo College of Medicine, 1-1 Mukogawa Nishinomiya, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112660653","display_name":"Masao Tachibana","orcid":"https://orcid.org/0009-0003-0890-9649","observed_orcids":["https://orcid.org/0009-0003-0890-9649"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masao Tachibana","raw_affiliation_strings":["Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan","Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112660653"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":2.6169,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.87906766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"10","first_page":"1268","last_page":"1276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.23389999568462372,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptic-ribbons","display_name":"synaptic ribbons","score":0.9229999780654907},{"id":"https://openalex.org/keywords/retinal-bipolar-cells","display_name":"retinal bipolar cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/synaptic-vesicle-fusion","display_name":"synaptic vesicle fusion","score":0.8149999976158142},{"id":"https://openalex.org/keywords/docked-vesicles","display_name":"docked vesicles","score":0.8080000281333923},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9089999794960022},{"id":"https://openalex.org/keywords/calcium-current","display_name":"calcium current","score":0.597000002861023},{"id":"https://openalex.org/keywords/goldfish-retina","display_name":"goldfish retina","score":0.7940000295639038},{"id":"https://openalex.org/keywords/postsynaptic-density","display_name":"postsynaptic density","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C38120836","wikidata":"https://www.wikidata.org/wiki/Q7322268","display_name":"Ribbon synapse","level":5,"score":0.9526666402816772},{"id":"https://openalex.org/C2780392137","wikidata":"https://www.wikidata.org/wiki/Q17121801","display_name":"Ribbon","level":2,"score":0.7630717754364014},{"id":"https://openalex.org/C187102610","wikidata":"https://www.wikidata.org/wiki/Q4677599","display_name":"Active zone","level":5,"score":0.7262024879455566},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.6929949522018433},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.593683123588562},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5926755666732788},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5693348050117493},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.501875638961792},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4736672043800354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4549519419670105},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.4398075044155121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3230544924736023},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20995298027992249},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11117467284202576},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10730248689651489},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05988943576812744},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001640","descriptor_name":"Bicuculline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006054","descriptor_name":"Goldfish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051245","descriptor_name":"Retinal Bipolar Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D051571","descriptor_name":"Protein Kinase C-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nn1963","doi":"https://doi.org/10.1038/nn1963","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nn1963","pdf_url":null,"source":{"id":"https://openalex.org/S2298632","display_name":"Nature Neuroscience","issn_l":"1097-6256","issn":["1097-6256","1546-1726"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Neuroscience","raw_type":"journal-article"},{"id":"pmid:17828257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17828257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1490441963","https://openalex.org/W1516563030","https://openalex.org/W1524148397","https://openalex.org/W1541733950","https://openalex.org/W1600158535","https://openalex.org/W1927867726","https://openalex.org/W1951170463","https://openalex.org/W1965893090","https://openalex.org/W1990220309","https://openalex.org/W1997301921","https://openalex.org/W2007337163","https://openalex.org/W2023739957","https://openalex.org/W2024710493","https://openalex.org/W2024881682","https://openalex.org/W2027397869","https://openalex.org/W2032074620","https://openalex.org/W2032998456","https://openalex.org/W2036047243","https://openalex.org/W2041236646","https://openalex.org/W2041899875","https://openalex.org/W2053689732","https://openalex.org/W2071469863","https://openalex.org/W2073298342","https://openalex.org/W2074378742","https://openalex.org/W2091966204","https://openalex.org/W2105658893","https://openalex.org/W2112152571","https://openalex.org/W2114089489","https://openalex.org/W2114838681","https://openalex.org/W2115172264","https://openalex.org/W2118720693","https://openalex.org/W2133133853","https://openalex.org/W2135791266","https://openalex.org/W2142036271","https://openalex.org/W2143831452","https://openalex.org/W2145119218","https://openalex.org/W2147111725","https://openalex.org/W2151022750","https://openalex.org/W2163967697","https://openalex.org/W2166672567","https://openalex.org/W2329726280"],"related_works":["https://openalex.org/W1516563030","https://openalex.org/W2021988358","https://openalex.org/W4404008287","https://openalex.org/W2151022750","https://openalex.org/W1996167057","https://openalex.org/W2030877422","https://openalex.org/W2750633128","https://openalex.org/W2114705990","https://openalex.org/W1980345625","https://openalex.org/W2020008923"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}