{"id":"https://openalex.org/W1978511113","doi":"https://doi.org/10.1371/journal.pntd.0001204","title":"TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia)","display_name":"TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia)","publication_year":2011,"publication_date":"2011-06-14","ids":{"openalex":"https://openalex.org/W1978511113","doi":"https://doi.org/10.1371/journal.pntd.0001204","mag":"1978511113","pmid":"https://pubmed.ncbi.nlm.nih.gov/21695103","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3114751"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0001204","doi":"https://doi.org/10.1371/journal.pntd.0001204","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0001204","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001204&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001204&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104109924","display_name":"Asha Jayakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asha Jayakumar","raw_affiliation_strings":["Yale University, School of Public Health, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, School of Public Health, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019869609","display_name":"Tiago Moreno Castilho","orcid":"https://orcid.org/0000-0003-2767-768X","observed_orcids":["https://orcid.org/0000-0003-2767-768X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiago M. Castilho","raw_affiliation_strings":["Yale University, School of Public Health, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, School of Public Health, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Esther Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther Park","raw_affiliation_strings":["Yale University, School of Public Health, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, School of Public Health, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070884217","display_name":"Karen Goldsmith\u2010Pestana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Goldsmith-Pestana","raw_affiliation_strings":["Yale University, School of Public Health, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, School of Public Health, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074203084","display_name":"Jenefer Mary Blackwell","orcid":"https://orcid.org/0000-0002-0784-7277","observed_orcids":["https://orcid.org/0000-0002-0784-7277"]},"institutions":[{"id":"https://openalex.org/I175234967","display_name":"The Kids Research Institute Australia","ror":"https://ror.org/01dbmzx78","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I175234967"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jenefer M. Blackwell","raw_affiliation_strings":["Centre for Child Health Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Child Health Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia","institution_ids":["https://openalex.org/I175234967","https://openalex.org/I177877127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112078600","display_name":"Diane McMahon\u2010Pratt","orcid":"https://orcid.org/0000-0003-0872-8779","observed_orcids":["https://orcid.org/0000-0003-0872-8779"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diane McMahon-Pratt","raw_affiliation_strings":["Yale University, School of Public Health, New Haven, Connecticut, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University, School of Public Health, New Haven, Connecticut, United States of America","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112078600"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":5.1976,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.95075061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"5","issue":"6","first_page":"e1204","last_page":"e1204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania-viannia-panamensis","display_name":"Leishmania (Viannia) panamensis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/leishmaniasis","display_name":"leishmaniasis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/heterologous-prime-boost-vaccination","display_name":"heterologous prime-boost","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pam3csk4","display_name":"Pam3CSK4","score":1.0},{"id":"https://openalex.org/keywords/tryparedoxin-peroxidase","display_name":"tryparedoxin peroxidase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.824999988079071},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8930000066757202},{"id":"https://openalex.org/keywords/innate-immune-modulation","display_name":"innate immune modulation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/vaccine-induced-protection","display_name":"vaccine-induced protection","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cd8-t-cell-depletion","display_name":"CD8+ T cell depletion","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.6716457605361938},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.5820010900497437},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5505828261375427},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.48435959219932556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44969895482063293},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.43528252840042114},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.4244478642940521},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.41541174054145813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3446228504180908},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2665403485298157},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.146168053150177},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10113531351089478},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.06325659155845642},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.05831801891326904},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.04559028148651123},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007117","descriptor_name":"Immunization, Secondary","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012376","descriptor_name":"Rodent Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012376","descriptor_name":"Rodent Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019444","descriptor_name":"Vaccines, DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051194","descriptor_name":"Toll-Like Receptor 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054332","descriptor_name":"Leishmaniasis Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D054332","descriptor_name":"Leishmaniasis Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pntd.0001204","doi":"https://doi.org/10.1371/journal.pntd.0001204","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0001204","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001204&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pure.atira.dk:openaire/e9a62898-e3c6-4824-955e-1fc30d8743c6","doi":null,"is_oa":true,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/e9a62898-e3c6-4824-955e-1fc30d8743c6","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jayakumar, A, Castilho, T M, Park, E, Goldsmith-Pestana, K, Blackwell, J & Mcmahon-Pratt, D 2011, 'TLR1/2 activation during Heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T cell responses providing protection against Leishmania (Viannia)', PLoS Neglected Tropical Diseases, vol. 5, no. 6, pp. 1-11. https://doi.org/10.1371/journal.pntd.0001204","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:21695103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21695103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3114751","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3114751/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.290.5372","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.290.5372","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/40/a1/PLoS_Negl_Trop_Dis_2011_Jun_14_5(6)_e1204.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6463a2698a0f4010b46fe38f4dca06a9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6463a2698a0f4010b46fe38f4dca06a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1204 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0001204","doi":"https://doi.org/10.1371/journal.pntd.0001204","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0001204","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001204&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G107225765","display_name":null,"funder_award_id":"R01 AI 06787","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2034299771","display_name":null,"funder_award_id":"R01 AI","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G673503253","display_name":null,"funder_award_id":"AI065866","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6998968119","display_name":"Collaborative Development of a Vaccine against Cutaneous and Visceral Leishmanias","funder_award_id":"R01AI067874","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7155145636","display_name":"Intervenable Host Leishmania (Viannia) Interactions","funder_award_id":"U19AI065866","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8799969499","display_name":null,"funder_award_id":"AI 06787","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978511113.pdf","grobid_xml":"https://content.openalex.org/works/W1978511113.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1510330021","https://openalex.org/W1514540900","https://openalex.org/W1515941168","https://openalex.org/W1531198730","https://openalex.org/W1544385648","https://openalex.org/W1550510823","https://openalex.org/W1568763343","https://openalex.org/W1600266371","https://openalex.org/W1603671650","https://openalex.org/W1826148430","https://openalex.org/W1963577621","https://openalex.org/W1965054845","https://openalex.org/W1966362727","https://openalex.org/W1976760334","https://openalex.org/W1978362888","https://openalex.org/W1979742563","https://openalex.org/W1980785560","https://openalex.org/W1984512389","https://openalex.org/W1991263982","https://openalex.org/W1995295711","https://openalex.org/W1997276741","https://openalex.org/W2007230171","https://openalex.org/W2010306932","https://openalex.org/W2021984977","https://openalex.org/W2024949498","https://openalex.org/W2027498866","https://openalex.org/W2031685585","https://openalex.org/W2033120984","https://openalex.org/W2033837180","https://openalex.org/W2035474364","https://openalex.org/W2037717220","https://openalex.org/W2039134318","https://openalex.org/W2047376205","https://openalex.org/W2049197565","https://openalex.org/W2049449911","https://openalex.org/W2050223302","https://openalex.org/W2051838113","https://openalex.org/W2051851091","https://openalex.org/W2058801589","https://openalex.org/W2061151696","https://openalex.org/W2064797931","https://openalex.org/W2066738380","https://openalex.org/W2067442540","https://openalex.org/W2071984833","https://openalex.org/W2074075011","https://openalex.org/W2084627532","https://openalex.org/W2096953466","https://openalex.org/W2099721805","https://openalex.org/W2103291317","https://openalex.org/W2105403778","https://openalex.org/W2105736351","https://openalex.org/W2106008384","https://openalex.org/W2108681289","https://openalex.org/W2109098886","https://openalex.org/W2109352986","https://openalex.org/W2111986891","https://openalex.org/W2114124188","https://openalex.org/W2114312842","https://openalex.org/W2114621889","https://openalex.org/W2117451755","https://openalex.org/W2119058768","https://openalex.org/W2126000538","https://openalex.org/W2127287184","https://openalex.org/W2128339423","https://openalex.org/W2129514368","https://openalex.org/W2140556676","https://openalex.org/W2141088834","https://openalex.org/W2141360780","https://openalex.org/W2143633104","https://openalex.org/W2145584783","https://openalex.org/W2152769327","https://openalex.org/W2153254832","https://openalex.org/W2156608186","https://openalex.org/W2158622713","https://openalex.org/W2159112596","https://openalex.org/W2159175227","https://openalex.org/W2160660031","https://openalex.org/W2160670021","https://openalex.org/W2165340588","https://openalex.org/W2170302951","https://openalex.org/W2171410982","https://openalex.org/W2320197099","https://openalex.org/W2321438857","https://openalex.org/W4313310004"],"related_works":["https://openalex.org/W7100380971","https://openalex.org/W2114621889","https://openalex.org/W1995543014","https://openalex.org/W1986640849","https://openalex.org/W1997842685","https://openalex.org/W2088100264","https://openalex.org/W2127287184","https://openalex.org/W2024822461","https://openalex.org/W2010460580","https://openalex.org/W2136599325"],"abstract_inverted_index":{"BACKGROUND:":[0],"Leishmania":[1,19,45,240,250,292],"(Viannia)":[2,61,241,293],"parasites":[3],"present":[4],"particular":[5],"challenges,":[6],"as":[7,155,157,189],"human":[8],"and":[9,38,64,149,152,160,164,223,226],"murine":[10],"immune":[11,122],"responses":[12,154,307],"to":[13,138,141,169,242],"infection":[14,42,63,142,289],"are":[15,47,308],"distinct":[16],"from":[17],"other":[18,44,247],"species,":[20],"indicating":[21,264],"a":[22,53,286],"unique":[23],"interaction":[24],"with":[25,259],"the":[26,65,81,120,125,195,216,231,237,266,283],"host.":[27],"Further,":[28,295],"vaccination":[29,76,100,133,256],"studies":[30],"utilizing":[31,101],"small":[32],"animal":[33],"models":[34],"indicate":[35],"that":[36,40,265,275],"modalities":[37],"antigens":[39],"prevent":[41],"by":[43,110,291],"species":[46,248],"generally":[48],"not":[49],"protective.":[50],"METHODOLOGY:":[51],"Using":[52],"newly":[54],"developed":[55],"mouse":[56],"model":[57],"of":[58,201,218,234,239,249,285],"chronic":[59],"L.":[60,111],"panamensis":[62],"heterologous":[66],"DNA":[67,130,135],"prime":[68,96],"-":[69,97],"modified":[70],"vaccinia":[71],"virus":[72],"Ankara":[73],"(MVA)":[74],"boost":[75,98],"modality,":[77],"we":[78],"examined":[79],"whether":[80],"conserved":[82],"vaccine":[83,243,287],"candidate":[84],"antigen":[85,103,219],"tryparedoxin":[86],"peroxidase":[87],"(TRYP)":[88],"could":[89],"provide":[90,105],"protection":[91,106,115,193,209],"against":[92,107,246,288],"infection/disease.":[93],"RESULTS:":[94],"Heterologous":[95],"(DNA/MVA)":[99],"TRYP":[102],"can":[104,258],"disease":[108,174],"caused":[109,290],"(V.)":[112],"panamensis.":[113],"However,":[114,254],"is":[116,210,251,269],"dependent":[117,211],"on":[118],"modulating":[119],"innate":[121],"response":[123],"using":[124,134],"TLR1/2":[126,213,296],"agonist":[127],"Pam3CSK4":[128],"during":[129],"priming.":[131],"Prime-boost":[132],"alone":[136],"fails":[137],"protect.":[139],"Prior":[140],"protectively":[143],"vaccinated":[144,196,198],"mice":[145,199],"exhibit":[146],"augmented":[147],"CD4":[148,202],"CD8":[150,178,190,221,276,304],"IFN\u03b3":[151],"memory":[153],"well":[156],"decreased":[158],"IL-10":[159,165,227],"IL-13":[161,163,225],"responses.":[162,228],"have":[166,181],"been":[167],"shown":[168],"be":[170,280,299],"independently":[171],"critical":[172],"for":[173,282],"in":[175,185,194,301],"this":[176],"model.":[177],"T":[179,203,277,305],"cells":[180,204,222,278],"an":[182],"essential":[183],"role":[184],"mediating":[186],"host":[187],"defense,":[188],"depletion":[191],"reversed":[192],"mice;":[197],"depleted":[200],"remained":[205],"protected.":[206],"Hence,":[207],"vaccine-induced":[208],"upon":[212],"activation":[214],"instructing":[215],"generation":[217],"specific":[220],"restricting":[224],"CONCLUSIONS:":[229],"Given":[230],"general":[232],"effectiveness":[233],"prime-boost":[235,255],"vaccination,":[236],"recalcitrance":[238],"approaches":[244],"effective":[245],"again":[252],"evident.":[253],"modality":[257],"modulation":[260,297],"induce":[261],"protective":[262],"responses,":[263],"delivery":[267],"system":[268],"critical.":[270,309],"Moreover,":[271],"these":[272],"results":[273],"suggest":[274],"should":[279],"targeted":[281],"development":[284],"parasites.":[294],"may":[298],"useful":[300],"vaccines":[302],"where":[303],"cell":[306]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}