{"id":"https://openalex.org/W1978510291","doi":"https://doi.org/10.1111/j.2042-7158.1996.tb03941.x","title":"In-vitro Bronchorelaxing Effects of Novel Nitric Oxide Donors GEA 3268 and GEA 5145 in Guinea-pigs and Rats","display_name":"In-vitro Bronchorelaxing Effects of Novel Nitric Oxide Donors GEA 3268 and GEA 5145 in Guinea-pigs and Rats","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W1978510291","doi":"https://doi.org/10.1111/j.2042-7158.1996.tb03941.x","mag":"1978510291","pmid":"https://pubmed.ncbi.nlm.nih.gov/9004196"},"language":"en","primary_location":{"id":"doi:10.1111/j.2042-7158.1996.tb03941.x","doi":"https://doi.org/10.1111/j.2042-7158.1996.tb03941.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2042-7158.1996.tb03941.x","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041102963","display_name":"Kirsi Vaali","orcid":"https://orcid.org/0000-0001-5402-8656","observed_orcids":["https://orcid.org/0000-0001-5402-8656"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Kirsi Vaali","raw_affiliation_strings":["Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100625190","display_name":"Liang Li","orcid":"https://orcid.org/0000-0003-2771-0910","observed_orcids":["https://orcid.org/0000-0003-2771-0910"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Liang Li","raw_affiliation_strings":["Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011650585","display_name":"B Redemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Beatrix Redemann","raw_affiliation_strings":["Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001546320","display_name":"Ilari Paakkari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ilari Paakkari","raw_affiliation_strings":["Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076752390","display_name":"Heikki Vapaatalo","orcid":"https://orcid.org/0000-0003-4348-8555","observed_orcids":["https://orcid.org/0000-0003-4348-8555"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Heikki Vapaatalo","raw_affiliation_strings":["Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8 FIN-00014, University of Helsinki ,","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, FIN-00014, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041102963"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":{"value":2911,"currency":"GBP","value_usd":3839},"apc_paid":null,"fwci":0.9981,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77437237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"48","issue":"12","first_page":"1309","last_page":"1314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bronchomotor-tone","display_name":"bronchomotor tone","score":0.781000018119812},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9079999923706055},{"id":"https://openalex.org/keywords/sin-1","display_name":"SIN-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nitrate-nitrite","display_name":"nitrite/nitrate","score":0.8389999866485596},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.734000027179718},{"id":"https://openalex.org/keywords/bronchoconstriction","display_name":"bronchoconstriction","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7473286390304565},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6926699876785278},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.6751073002815247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4471585154533386},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40716373920440674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3683074116706848},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3349526524543762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29425516724586487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11897173523902893}],"mesh":[{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008981","descriptor_name":"Molsidomine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008981","descriptor_name":"Molsidomine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.2042-7158.1996.tb03941.x","doi":"https://doi.org/10.1111/j.2042-7158.1996.tb03941.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2042-7158.1996.tb03941.x","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:9004196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9004196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacy and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309952","display_name":"Ida Montinin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0269hs475"},{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W90778696","https://openalex.org/W222593177","https://openalex.org/W1566432490","https://openalex.org/W1882790052","https://openalex.org/W1965016397","https://openalex.org/W1970638489","https://openalex.org/W1989562771","https://openalex.org/W1989584865","https://openalex.org/W2007529944","https://openalex.org/W2011521821","https://openalex.org/W2016253529","https://openalex.org/W2018815182","https://openalex.org/W2032374099","https://openalex.org/W2044221226","https://openalex.org/W2062683293","https://openalex.org/W2062936676","https://openalex.org/W2079342899","https://openalex.org/W2088082611","https://openalex.org/W2112487069","https://openalex.org/W2153319596","https://openalex.org/W2280605152","https://openalex.org/W2305269538","https://openalex.org/W2342548629","https://openalex.org/W2395952104","https://openalex.org/W2410895035","https://openalex.org/W2442045178","https://openalex.org/W2474640588","https://openalex.org/W4241101943","https://openalex.org/W4243777116","https://openalex.org/W6639343515","https://openalex.org/W6718817101"],"related_works":["https://openalex.org/W2464391209","https://openalex.org/W2083116124","https://openalex.org/W1972300311","https://openalex.org/W2130408845","https://openalex.org/W2191920958","https://openalex.org/W7120534686","https://openalex.org/W2008509462","https://openalex.org/W2153319596","https://openalex.org/W2046301358","https://openalex.org/W2039494975"],"abstract_inverted_index":{"Endogenously":[0],"released":[1],"nitric":[2],"oxide":[3],"(NO)":[4],"in":[5,20,84,97,184],"airways":[6],"might":[7,16],"contribute":[8],"to":[9,33,77,101,113],"physiological":[10],"bronchodilation;":[11],"induced":[12,161],"production":[13],"of":[14,23,45,54,70,86,109,179,187,208],"NO":[15,46,55,111,126,141,171,216],"play":[17],"a":[18,30],"role":[19],"the":[21,43,51,78,103,110,121,139,158,162,169,180,185,206,209,222,225,230],"pathogenesis":[22],"asthma,":[24],"although":[25],"it":[26],"could":[27],"also":[28,95],"be":[29],"compensatory":[31],"mechanism":[32],"other":[34],"factors":[35],"that":[36,215],"cause":[37],"bronchoconstriction":[38],"or":[39,173],"inflammation.":[40],"To":[41],"investigate":[42],"efficacy":[44,207],"donors":[47,112,127,142,172],"on":[48,229],"bronchial":[49],"tone,":[50],"bronchorelaxing":[52,136],"efficacies":[53],"donors,":[56],"new":[57],"experimental":[58],"GEA":[59,128,131,159,190,192],"compounds":[60,160],"3268":[61,129],"and":[62,73,76,88,116,130,145,198,224,233],"5145":[63,132],"(oxatriazole":[64],"sulphonylamides)":[65],"were":[66,94,133],"compared":[67,167],"with":[68,168,174,205],"those":[69],"sodium":[71,143,194],"nitroprusside":[72,144],"SIN-1":[74],"(3-morpholinosydnonimine)":[75],"standard":[79],"beta":[80],"2-adrenergic":[81],"agonist,":[82],"salbutamol,":[83,188],"bronchi":[85,157],"guinea-pigs":[87],"rats":[89],"in-vitro.":[90],"Their":[91],"relaxing":[92],"effects":[93],"studied":[96,182],"rat":[98,156],"mesentery":[99],"arteries":[100],"compare":[102],"selectivity":[104,178],"for":[105,221],"airways.":[106],"The":[107,124,176,196,211],"capacity":[108],"produce":[114],"nitrites":[115,197],"nitrates":[117,199],"was":[118,152],"assayed":[119],"by":[120],"Griess":[122],"reaction.":[123],"novel":[125],"more":[134],"potent":[135],"agents":[137,235],"than":[138],"old":[140,170],"SIN-1.":[146],"In":[147,155],"guinea-pig":[148],"bronchi,":[149],"however,":[150],"salbutamol":[151],"most":[153],"potent.":[154],"strongest":[163],"relaxation":[164,223],"effect":[165],"when":[166],"salbutamol.":[175],"airway":[177],"drugs":[181],"decreased":[183],"order":[186],"SIN-1,":[189],"5145,":[191],"3268,":[193],"nitroprusside.":[195],"produced":[200],"spontaneously":[201],"did":[202],"not":[203],"correlate":[204],"relaxants.":[210],"results":[212],"obtained":[213],"suggest":[214],"is":[217,227],"only":[218],"partly":[219],"responsible":[220],"potency":[226],"dependent":[228],"animal":[231],"species":[232],"constricting":[234],"used.":[236]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
