{"id":"https://openalex.org/W1978482835","doi":"https://doi.org/10.1021/bi00163a009","title":"Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene","display_name":"Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene","publication_year":1992,"publication_date":"1992-12-08","ids":{"openalex":"https://openalex.org/W1978482835","doi":"https://doi.org/10.1021/bi00163a009","mag":"1978482835","pmid":"https://pubmed.ncbi.nlm.nih.gov/1457401"},"language":"en","primary_location":{"id":"doi:10.1021/bi00163a009","doi":"https://doi.org/10.1021/bi00163a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00163a009","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103523462","display_name":"Peter G. Milner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135078","display_name":"Washington University Medical Center","ror":"https://ror.org/036c27j91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135078"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G. Milner","raw_affiliation_strings":["Department of Medicine, Washington University Medical Center, St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University Medical Center, St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I4210135078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000391646","display_name":"Dulari D. Shah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dulari Shah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058416943","display_name":"Rosalie Veile","orcid":"https://orcid.org/0000-0002-0139-7498","observed_orcids":["https://orcid.org/0000-0002-0139-7498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalie Veile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112163245","display_name":"Helen Donis-Keller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen Donis-Keller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028279092","display_name":"B. Vijaya Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Vijaya Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.894,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.70064798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"31","issue":"48","first_page":"12023","last_page":"12028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pleiotrophin","display_name":"pleiotrophin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/midkine","display_name":"midkine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gene-family","display_name":"gene family","score":0.4830000102519989},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.8569999933242798},{"id":"https://openalex.org/keywords/exon-intron-organization","display_name":"exon-intron organization","score":0.890999972820282},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cysteine-residues","display_name":"cysteine residues","score":0.8730000257492065},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.8600000143051147},{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.6790000200271606},{"id":"https://openalex.org/keywords/human-mouse-gene-comparison","display_name":"human-mouse gene comparison","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2779822564","wikidata":"https://www.wikidata.org/wiki/Q14916160","display_name":"Pleiotrophin","level":4,"score":0.7880672216415405},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6786184310913086},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.5438429117202759},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.5416920185089111},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5184459090232849},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.5143553018569946},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.44524332880973816},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.42910319566726685},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.3520962595939636},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3272421956062317},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25999534130096436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19550558924674988},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002897","descriptor_name":"Chromosomes, Human, Pair 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015183","descriptor_name":"Restriction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00163a009","doi":"https://doi.org/10.1021/bi00163a009","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00163a009","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:1457401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1457401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5733446017","display_name":"MECHANISMS OF ANGIOGENESIS IN THE FETUS AND NEWBORN","funder_award_id":"R29HL047380","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G597266577","display_name":null,"funder_award_id":"HL47380-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6373534066","display_name":"A COMPLETE GENETIC LINKAGE MAP OF THE HUMAN GENOME","funder_award_id":"R01HG000304","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1233202794","https://openalex.org/W1516205253","https://openalex.org/W1533264337","https://openalex.org/W1549915596","https://openalex.org/W1949772518","https://openalex.org/W1966471720","https://openalex.org/W1976001233","https://openalex.org/W1985886714","https://openalex.org/W2016314843","https://openalex.org/W2018839286","https://openalex.org/W2029725196","https://openalex.org/W2029987769","https://openalex.org/W2032040395","https://openalex.org/W2046723647","https://openalex.org/W2054131429","https://openalex.org/W2059587416","https://openalex.org/W2061536183","https://openalex.org/W2074030659","https://openalex.org/W2086569587","https://openalex.org/W2091483151","https://openalex.org/W2108494826","https://openalex.org/W2116302199","https://openalex.org/W2116706550","https://openalex.org/W2138270253"],"related_works":["https://openalex.org/W1535606887","https://openalex.org/W2045616312","https://openalex.org/W1967718758","https://openalex.org/W2074030659","https://openalex.org/W2013800356","https://openalex.org/W4256243185","https://openalex.org/W1983529326","https://openalex.org/W1985760282","https://openalex.org/W2071778163","https://openalex.org/W2003434471"],"abstract_inverted_index":{"Pleiotrophin":[0],"(PTN),":[1],"midkine":[2],"(MK),":[3],"and":[4,29,41,60,129,140,160,204,226],"retinoic":[5],"acid-induced":[6],"heparin-binding":[7],"(RI-HB)":[8],"protein":[9],"are":[10],"members":[11],"of":[12,17,32,36,69,91,102,108,116,124,131,142,149,171,208,217,222,229,231,253,258],"a":[13,64,254],"recently":[14],"discovered":[15],"family":[16,257],"developmentally":[18,259],"regulated":[19,260],"cytokines.":[20,261],"We":[21,211],"report":[22,213],"here":[23],"the":[24,33,37,45,70,89,92,98,106,121,143,150,161,176,190,195,200,205,218,223,227,251],"cloning,":[25],"sequencing,":[26],"chromosomal":[27],"localization,":[28],"structural":[30],"organization":[31],"genomic":[34],"version":[35],"human":[38,234,240],"PTN":[39,50,132,224,236],"gene":[40,51,109,225,256],"its":[42],"comparison":[43],"to":[44,54,67,82,137,184,239],"mouse":[46,71],"MK":[47,72,93,144],"gene.":[48,73],"The":[49,111,167,179],"was":[52,237],"found":[53,183],"be":[55,185],"arranged":[56],"in":[57,63,88,146,157,164,189,233,245],"five":[58],"exons":[59,138],"four":[61],"introns,":[62],"fashion":[65],"similar":[66],"that":[68],"Exon":[74],"1,":[75],"as":[76],"for":[77,156],"MK,":[78],"does":[79],"not":[80],"appear":[81],"encode":[83],"amino":[84],"acid":[85],"sequence.":[86],"As":[87],"case":[90],"gene,":[94],"exon":[95,125,158,165,192],"2":[96],"encodes":[97,194],"hydrophobic":[99],"leader":[100],"sequence":[101,221],"PTN,":[103],"which":[104,193],"constitutes":[105],"beginning":[107],"translation.":[110],"signal":[112,207],"peptide":[113],"cleavage":[114],"site":[115,228],"both":[117,172,209],"genes":[118,173,181],"lies":[119],"toward":[120],"3'":[122],"end":[123],"2.":[126],"Exons":[127],"3":[128,139,159],"4":[130,141,163],"were":[133,154,182],"most":[134],"closely":[135,187],"related":[136,188],"gene;":[145],"particular,":[147],"six":[148],"ten":[151],"cysteine":[152],"residues":[153],"coded":[155],"remaining":[162],"4.":[166],"intron-exon":[168],"splice":[169],"junctions":[170],"occurred":[174],"through":[175],"same":[177],"residues.":[178],"two":[180],"less":[186],"fifth":[191],"highly":[196],"basic":[197],"C-terminal":[198],"domains,":[199],"translation":[201],"termination":[202],"codon,":[203],"polyadenylation":[206],"cDNAs.":[210],"also":[212],"approximately":[214],"2000":[215],"bp":[216],"5'":[219],"untranslated":[220],"initiation":[230],"transcription":[232],"placenta.":[235],"localized":[238],"chromosome":[241],"7q33-34":[242],"by":[243],"fluorescence":[244],"situ":[246],"hybridization.":[247],"These":[248],"data":[249],"confirm":[250],"existence":[252],"new":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}