{"id":"https://openalex.org/W1978477577","doi":"https://doi.org/10.1208/s12249-009-9197-2","title":"Diazepam-Loaded Solid Lipid Nanoparticles: Design and Characterization","display_name":"Diazepam-Loaded Solid Lipid Nanoparticles: Design and Characterization","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W1978477577","doi":"https://doi.org/10.1208/s12249-009-9197-2","mag":"1978477577","pmid":"https://pubmed.ncbi.nlm.nih.gov/19277870","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2663687"},"language":"en","primary_location":{"id":"doi:10.1208/s12249-009-9197-2","doi":"https://doi.org/10.1208/s12249-009-9197-2","is_oa":true,"landing_page_url":"https://doi.org/10.1208/s12249-009-9197-2","pdf_url":"https://link.springer.com/content/pdf/10.1208/s12249-009-9197-2.pdf","source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1208/s12249-009-9197-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015617681","display_name":"Ghada Ahmed Abdelbary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ghada Abdelbary","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt. gabdelbary@gmail.com","Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt. gabdelbary@gmail.com","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University , Cairo , Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034930631","display_name":"Rania Hassan Fahmy","orcid":"https://orcid.org/0000-0002-8762-3272","observed_orcids":["https://orcid.org/0000-0002-8762-3272"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rania H. Fahmy","raw_affiliation_strings":["Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., 11562, Cairo, Egypt","Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University , Cairo , Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini St., 11562, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University , Cairo , Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015617681"],"corresponding_institution_ids":["https://openalex.org/I145487455"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":6.2105,"has_fulltext":true,"cited_by_count":250,"citation_normalized_percentile":{"value":0.97653631,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"211","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.2020999938249588,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.9929999709129333},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/rectal-suppositories","display_name":"rectal suppositories","score":0.7409999966621399},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.699999988079071},{"id":"https://openalex.org/keywords/poloxamer-188","display_name":"poloxamer 188","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tween-80","display_name":"Tween 80","score":0.984000027179718},{"id":"https://openalex.org/keywords/lipid-matrix","display_name":"lipid matrix","score":0.6340000033378601},{"id":"https://openalex.org/keywords/surfactants","display_name":"surfactants","score":0.6629999876022339},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nanoparticle-size","display_name":"nanoparticle size","score":0.7120000123977661},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.9089795351028442},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.7302287817001343},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.7179415225982666},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.6145912408828735},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.575905978679657},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5552812218666077},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5550200343132019},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5530498623847961},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4698445200920105},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4376925230026245},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39619728922843933},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24898722767829895},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1944202184677124},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.17004412412643433},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.1608818769454956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07168707251548767},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000285","descriptor_name":"Administration, Rectal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011136","descriptor_name":"Polysorbates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013488","descriptor_name":"Suppositories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013501","descriptor_name":"Surface-Active Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013678","descriptor_name":"Technology, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014465","descriptor_name":"Ultrasonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020442","descriptor_name":"Poloxamer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1208/s12249-009-9197-2","doi":"https://doi.org/10.1208/s12249-009-9197-2","is_oa":true,"landing_page_url":"https://doi.org/10.1208/s12249-009-9197-2","pdf_url":"https://link.springer.com/content/pdf/10.1208/s12249-009-9197-2.pdf","source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},{"id":"pmid:19277870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19277870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2663687","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2663687/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1208/s12249-009-9197-2","doi":"https://doi.org/10.1208/s12249-009-9197-2","is_oa":true,"landing_page_url":"https://doi.org/10.1208/s12249-009-9197-2","pdf_url":"https://link.springer.com/content/pdf/10.1208/s12249-009-9197-2.pdf","source":{"id":"https://openalex.org/S1234972","display_name":"AAPS PharmSciTech","issn_l":"1530-9932","issn":["1530-9932"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"AAPS PharmSciTech","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978477577.pdf","grobid_xml":"https://content.openalex.org/works/W1978477577.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1532288551","https://openalex.org/W1555994455","https://openalex.org/W1579046626","https://openalex.org/W1607190898","https://openalex.org/W1682768769","https://openalex.org/W1964026121","https://openalex.org/W1970352716","https://openalex.org/W1977497240","https://openalex.org/W1977755432","https://openalex.org/W1991285135","https://openalex.org/W1999122040","https://openalex.org/W2005417070","https://openalex.org/W2007893172","https://openalex.org/W2011920500","https://openalex.org/W2011941976","https://openalex.org/W2012230325","https://openalex.org/W2019355258","https://openalex.org/W2021360813","https://openalex.org/W2029702757","https://openalex.org/W2030129351","https://openalex.org/W2033390870","https://openalex.org/W2034697702","https://openalex.org/W2054189154","https://openalex.org/W2055449190","https://openalex.org/W2061609341","https://openalex.org/W2064525110","https://openalex.org/W2065946738","https://openalex.org/W2068672573","https://openalex.org/W2071872569","https://openalex.org/W2085770062","https://openalex.org/W2122032638","https://openalex.org/W2128863256","https://openalex.org/W2146408988","https://openalex.org/W2159859765","https://openalex.org/W2480083684","https://openalex.org/W2486139341","https://openalex.org/W2757096322","https://openalex.org/W2789777227","https://openalex.org/W2973099831","https://openalex.org/W2993155701","https://openalex.org/W4285719527","https://openalex.org/W6805748407"],"related_works":["https://openalex.org/W3091008894","https://openalex.org/W4408570898","https://openalex.org/W3045569112","https://openalex.org/W4312194725","https://openalex.org/W2379274964","https://openalex.org/W2347270736","https://openalex.org/W2050029045","https://openalex.org/W4394948894","https://openalex.org/W3217799968","https://openalex.org/W2045422927"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}