{"id":"https://openalex.org/W1978477308","doi":"https://doi.org/10.1016/j.bmc.2006.05.007","title":"Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles","display_name":"Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles","publication_year":2006,"publication_date":"2006-05-23","ids":{"openalex":"https://openalex.org/W1978477308","doi":"https://doi.org/10.1016/j.bmc.2006.05.007","mag":"1978477308","pmid":"https://pubmed.ncbi.nlm.nih.gov/16714116"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmc.2006.05.007","doi":"https://doi.org/10.1016/j.bmc.2006.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2006.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978477308"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025501724","display_name":"Shuting Huang","orcid":"https://orcid.org/0000-0002-1526-8048","observed_orcids":["https://orcid.org/0000-0002-1526-8048"]},"institutions":[{"id":"https://openalex.org/I33096239","display_name":"National Dong Hwa University","ror":"https://ror.org/00mng9617","country_code":"TW","type":"education","lineage":["https://openalex.org/I33096239"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shu-Ting Huang","raw_affiliation_strings":["Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan","institution_ids":["https://openalex.org/I33096239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087551827","display_name":"I-Jen Hsei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Jen Hsei","raw_affiliation_strings":["Department of Medical Laboratory Science and Biotechnology, College of Medicine, Tzu Chi University, Hualien 970, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science and Biotechnology, College of Medicine, Tzu Chi University, Hualien 970, Taiwan","institution_ids":["https://openalex.org/I189772984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072102407","display_name":"Chinpiao Chen","orcid":"https://orcid.org/0000-0002-9904-1085","observed_orcids":["https://orcid.org/0000-0002-9904-1085"]},"institutions":[{"id":"https://openalex.org/I33096239","display_name":"National Dong Hwa University","ror":"https://ror.org/00mng9617","country_code":"TW","type":"education","lineage":["https://openalex.org/I33096239"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chinpiao Chen","raw_affiliation_strings":["Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien 974, Taiwan","institution_ids":["https://openalex.org/I33096239"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072102407"],"corresponding_institution_ids":["https://openalex.org/I33096239"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":3.3535,"has_fulltext":false,"cited_by_count":347,"citation_normalized_percentile":{"value":0.92218452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"14","issue":"17","first_page":"6106","last_page":"6119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14459","display_name":"Synthesis and Reactions of Organic Compounds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bisbenzimidazole","display_name":"bisbenzimidazole","score":0.9679999947547913},{"id":"https://openalex.org/keywords/benzothiazole","display_name":"benzothiazole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.781000018119812},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lung-cancer-cell-lines","display_name":"lung cancer cell lines","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7440000176429749},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rd-cells","display_name":"RD cells","score":0.5440000295639038},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.9689465761184692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8830462694168091},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8026387691497803},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.664107084274292},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6594124436378479},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6349353194236755},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5948900580406189},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.4757261574268341},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.44799771904945374},{"id":"https://openalex.org/C2909082478","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma Cell","level":3,"score":0.441723108291626},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.40379735827445984},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.39727783203125},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35362154245376587},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2674029469490051},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2022932469844818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04612523317337036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bmc.2006.05.007","doi":"https://doi.org/10.1016/j.bmc.2006.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2006.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:16714116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16714116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:ir.ndhu.edu.tw:987654321/8700","doi":null,"is_oa":false,"landing_page_url":"http://ir.ndhu.edu.tw/handle/987654321/8700","pdf_url":null,"source":{"id":"https://openalex.org/S7407064279","display_name":"National Dong Hwa University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W118485594","https://openalex.org/W1964704258","https://openalex.org/W1968768181","https://openalex.org/W1970090901","https://openalex.org/W1978809900","https://openalex.org/W1982445402","https://openalex.org/W2013906321","https://openalex.org/W2020780349","https://openalex.org/W2037687481","https://openalex.org/W2058880816","https://openalex.org/W2063443576","https://openalex.org/W2094820708","https://openalex.org/W2124524255","https://openalex.org/W2128150360","https://openalex.org/W2172407107","https://openalex.org/W2325590655","https://openalex.org/W4231872441"],"related_works":["https://openalex.org/W2063443576","https://openalex.org/W2095395178","https://openalex.org/W2742108729","https://openalex.org/W1980423041","https://openalex.org/W4281962904","https://openalex.org/W2408816724","https://openalex.org/W2953096848","https://openalex.org/W2743091213","https://openalex.org/W2160030461"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
