{"id":"https://openalex.org/W1978475423","doi":"https://doi.org/10.1056/nejm199008233230803","title":"Evaluation of Systemic Amyloidosis by Scintigraphy with123I-Labeled Serum Amyloid P Component","display_name":"Evaluation of Systemic Amyloidosis by Scintigraphy with123I-Labeled Serum Amyloid P Component","publication_year":1990,"publication_date":"1990-08-23","ids":{"openalex":"https://openalex.org/W1978475423","doi":"https://doi.org/10.1056/nejm199008233230803","mag":"1978475423","pmid":"https://pubmed.ncbi.nlm.nih.gov/2377176"},"language":"en","primary_location":{"id":"doi:10.1056/nejm199008233230803","doi":"https://doi.org/10.1056/nejm199008233230803","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199008233230803","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199008233230803?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1978475423"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199008233230803?articleTools=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033490022","display_name":"Philip Nigel Hawkins","orcid":"https://orcid.org/0000-0002-6983-9598","observed_orcids":["https://orcid.org/0000-0002-6983-9598","https://orcid.org/0000-0002-6979-0464"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip N. Hawkins","raw_affiliation_strings":["Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","Immunological Medicine Unit, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I2801748203"]},{"raw_affiliation_string":"Immunological Medicine Unit, Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109479841","display_name":"J. P. Lavender","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Peter Lavender","raw_affiliation_strings":["Nuclear Medicine Unit, Department of Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London. Address reprint requests to Dr. Hawkins at the Immunological Medicine Unit, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Rd., London W12 0NN, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine Unit, Department of Radiology, Royal Postgraduate Medical School, Hammersmith Hospital, London. Address reprint requests to Dr. Hawkins at the Immunological Medicine Unit, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Rd., London W12 0NN, United Kingdom","institution_ids":["https://openalex.org/I2801748203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079554246","display_name":"Mark B. Pepys","orcid":"https://orcid.org/0000-0003-2614-3248","observed_orcids":["https://orcid.org/0000-0003-2614-3248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark B. Pepys","raw_affiliation_strings":["Immunological Medicine Unit, Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunological Medicine Unit, Department of Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":32.8726,"has_fulltext":false,"cited_by_count":533,"citation_normalized_percentile":{"value":0.99818182,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"323","issue":"8","first_page":"508","last_page":"513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-amyloidosis","display_name":"systemic amyloidosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/serum-amyloid-p-component","display_name":"serum amyloid P component","score":0.953000009059906},{"id":"https://openalex.org/keywords/iodine-123","display_name":"iodine-123","score":0.8240000009536743},{"id":"https://openalex.org/keywords/al-amyloidosis","display_name":"AL amyloidosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/aa-amyloidosis","display_name":"AA amyloidosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-surveillance","display_name":"disease surveillance","score":0.722000002861023},{"id":"https://openalex.org/keywords/spleen-involvement","display_name":"spleen involvement","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cardiac-amyloidosis","display_name":"cardiac amyloidosis","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.8739070296287537},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8160715103149414},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.7552030086517334},{"id":"https://openalex.org/C2779902710","wikidata":"https://www.wikidata.org/wiki/Q1130465","display_name":"Scintigraphy","level":2,"score":0.6007914543151855},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6001757383346558},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.59850013256073},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.5674788355827332},{"id":"https://openalex.org/C2779551797","wikidata":"https://www.wikidata.org/wiki/Q4652470","display_name":"AL amyloidosis","level":4,"score":0.5580548644065857},{"id":"https://openalex.org/C2780029684","wikidata":"https://www.wikidata.org/wiki/Q14891716","display_name":"Serum amyloid P component","level":4,"score":0.5353562831878662},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.5214499831199646},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4283779561519623},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3055099546909332},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26828378438949585},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15719127655029297},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.13030365109443665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11013257503509521},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000683","descriptor_name":"Serum Amyloid P-Component","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1056/nejm199008233230803","doi":"https://doi.org/10.1056/nejm199008233230803","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199008233230803","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199008233230803?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:2377176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2377176","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1370355","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1370355/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NEW ENGLAND JOURNAL OF MEDICINE , 323 (8) pp. 508-513. (1990)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1056/nejm199008233230803","doi":"https://doi.org/10.1056/nejm199008233230803","is_oa":true,"landing_page_url":"https://doi.org/10.1056/nejm199008233230803","pdf_url":"https://www.nejm.org/doi/pdf/10.1056/NEJM199008233230803?articleTools=true","source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1978475423.pdf"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W39869391","https://openalex.org/W1480950303","https://openalex.org/W1504283257","https://openalex.org/W1763925711","https://openalex.org/W1969649688","https://openalex.org/W1972901673","https://openalex.org/W1984759928","https://openalex.org/W1998468541","https://openalex.org/W2003711194","https://openalex.org/W2011841989","https://openalex.org/W2037723208","https://openalex.org/W2040849321","https://openalex.org/W2043298053","https://openalex.org/W2049089375","https://openalex.org/W2061647900","https://openalex.org/W2065562329","https://openalex.org/W2076467891","https://openalex.org/W2108172045","https://openalex.org/W2108427207","https://openalex.org/W2114159444","https://openalex.org/W2117008792","https://openalex.org/W2143942727","https://openalex.org/W2158647547","https://openalex.org/W2395350297","https://openalex.org/W2413216990","https://openalex.org/W2415752449","https://openalex.org/W2416105660","https://openalex.org/W2479993982"],"related_works":["https://openalex.org/W2499464403","https://openalex.org/W2072587452","https://openalex.org/W1986663062","https://openalex.org/W2120388056","https://openalex.org/W1966937637","https://openalex.org/W2114159444","https://openalex.org/W2078204836","https://openalex.org/W2509383735","https://openalex.org/W2029321602"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,116,165],"systemic":[2,75,253],"amyloidosis":[3,120,170],"the":[4,78,85,117,121,141,155,158,162,171,176,181,193,238,250],"distribution":[5],"and":[6,82,95,101,109,126,137,161,186,248],"progression":[7],"of":[8,41,143,154,230,240,252],"disease":[9,94],"have":[10],"been":[11,207],"difficult":[12],"to":[13,56,70,89,139],"monitor,":[14],"because":[15,40],"they":[16],"can":[17,242],"be":[18,54,243],"demonstrated":[19],"only":[20,189],"by":[21,157],"biopsy.":[22],"Serum":[23],"amyloid":[24,38,58,129,144,214,224],"P":[25],"component":[26],"(SAP)":[27],"is":[28,35],"a":[29,112],"normal":[30],"circulating":[31],"plasma":[32],"protein":[33],"that":[34],"deposited":[36],"on":[37,218],"fibrils":[39],"its":[42],"specific":[43],"binding":[44],"affinity":[45],"for":[46,245],"them.":[47],"We":[48],"investigated":[49],"whether":[50],"labeled":[51,64],"SAP":[52,63],"could":[53],"used":[55,244],"locate":[57],"deposits.":[59,130],"METHODS:":[60],"Purified":[61],"human":[62],"with":[65,73,77,84,93,119,168,192],"iodine-123":[66],"was":[67,123,151,173,215,226],"given":[68],"intravenously":[69],"50":[71,148],"patients":[72,92,118,160,167,191,202,232],"biopsy-proved":[74],"amyloidosis--25":[76],"AL":[79,194],"(primary)":[80],"type":[81],"25":[83],"AA":[86,169],"(secondary)":[87],"type--and":[88],"26":[90],"control":[91,159],"10":[96],"healthy":[97,163],"subjects.":[98,164],"Whole-body":[99],"images":[100,133,197],"regional":[102],"views":[103],"were":[104,135,198],"obtained":[105,134],"after":[106,237],"24":[107],"hours":[108],"read":[110],"in":[111,128,146,180,190,200,203,211,228],"blinded":[113],"fashion.":[114],"RESULTS:":[115],"123I-SAP":[122,156,241],"localized":[124],"rapidly":[125],"specifically":[127],"The":[131],"scintigraphic":[132],"characteristic":[136],"appeared":[138],"identify":[140],"extent":[142,251],"deposition":[145,225],"all":[147,166,212],"patients.":[149],"There":[150],"no":[152],"uptake":[153,179],"spleen":[172],"affected,":[174],"whereas":[175],"scans":[177],"showed":[178],"heart,":[182],"skin,":[183],"carpal":[184],"region,":[185],"bone":[187],"marrow":[188],"type.":[195],"Positive":[196],"seen":[199],"six":[201],"whom":[204],"biopsies":[205],"had":[206],"negative":[208],"or":[209,220],"unsuccessful;":[210],"six,":[213],"subsequently":[216],"found":[217],"biopsy":[219],"at":[221],"autopsy.":[222],"Progressive":[223],"observed":[227],"9":[229],"11":[231],"studied":[233],"serially.":[234],"CONCLUSIONS:":[235],"Scintigraphy":[236],"injection":[239],"diagnosing,":[246],"locating,":[247],"monitoring":[249],"amyloidosis.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}