{"id":"https://openalex.org/W1978460161","doi":"https://doi.org/10.1002/ijc.26415","title":"Involvement of the TGF\u03b2 pathway in the regulation of \u03b15\u03b21 integrins by caveolin\u20101 in human glioblastoma","display_name":"Involvement of the TGF\u03b2 pathway in the regulation of \u03b15\u03b21 integrins by caveolin\u20101 in human glioblastoma","publication_year":2011,"publication_date":"2011-09-07","ids":{"openalex":"https://openalex.org/W1978460161","doi":"https://doi.org/10.1002/ijc.26415","mag":"1978460161","pmid":"https://pubmed.ncbi.nlm.nih.gov/21901744"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.26415","doi":"https://doi.org/10.1002/ijc.26415","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.26415","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023172789","display_name":"Erika C. Cosset","orcid":"https://orcid.org/0000-0001-5481-6556","observed_orcids":["https://orcid.org/0000-0001-5481-6556"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405257448","display_name":"Laboratoire de bioimagerie et pathologies","ror":"https://ror.org/059g0vd42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Erika C. Cosset","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012759219","display_name":"Julien Godet","orcid":"https://orcid.org/0000-0002-8470-0092","observed_orcids":["https://orcid.org/0000-0002-8470-0092"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405257448","display_name":"Laboratoire de bioimagerie et pathologies","ror":"https://ror.org/059g0vd42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Godet","raw_affiliation_strings":["De\u0301partement d'Informations Me\u0301dicales, Strasbourg, France","Universite\u0301 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","D\u00e9partement d'Informations M\u00e9dicales, Strasbourg, France","Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"De\u0301partement d'Informations Me\u0301dicales, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Universite\u0301 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"raw_affiliation_string":"D\u00e9partement d'Informations M\u00e9dicales, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019781329","display_name":"Natacha Entz\u2010Werl\u00e9","orcid":"https://orcid.org/0000-0001-8418-7439","observed_orcids":["https://orcid.org/0000-0001-8418-7439"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natacha Entz\u2010Werl\u00e9","raw_affiliation_strings":["EA4438, Physiopathologie et Recherche Translationnelle, Strasbourg, France","Service de Biochimie et Biologie Mole\u0301culaire, Strasbourg, France","Service de Biochimie et Biologie Mol\u00e9culaire, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA4438, Physiopathologie et Recherche Translationnelle, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Service de Biochimie et Biologie Mole\u0301culaire, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Service de Biochimie et Biologie Mol\u00e9culaire, Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008277545","display_name":"\u00c9ric Gu\u00e9rin","orcid":"https://orcid.org/0000-0003-1388-2834","observed_orcids":["https://orcid.org/0000-0003-1388-2834"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Gu\u00e9rin","raw_affiliation_strings":["EA4438, Physiopathologie et Recherche Translationnelle, Strasbourg, France","Service de Biochimie et Biologie Mole\u0301culaire, Strasbourg, France","Service de Biochimie et Biologie Mol\u00e9culaire, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA4438, Physiopathologie et Recherche Translationnelle, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Service de Biochimie et Biologie Mole\u0301culaire, Strasbourg, France","institution_ids":[]},{"raw_affiliation_string":"Service de Biochimie et Biologie Mol\u00e9culaire, Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002733423","display_name":"Dominique Gu\u00e9not","orcid":"https://orcid.org/0000-0003-2782-8425","observed_orcids":["https://orcid.org/0000-0003-2782-8425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dominique Guenot","raw_affiliation_strings":["EA4438, Physiopathologie et Recherche Translationnelle, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EA4438, Physiopathologie et Recherche Translationnelle, Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058494604","display_name":"Sebastien C. Froelich","orcid":"https://orcid.org/0000-0001-9124-2395","observed_orcids":["https://orcid.org/0000-0001-9124-2395"]},"institutions":[{"id":"https://openalex.org/I4210157127","display_name":"H\u00f4pital d'Hautepierre","ror":"https://ror.org/04e1w6923","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210145324","https://openalex.org/I4210157127"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Froelich","raw_affiliation_strings":["Service de Neurochirurgie, Ho\u0302pital de Hautepierre, CHRU Strasbourg, France","Service de Neurochirurgie, H\u00f4pital de Hautepierre, CHRU Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurochirurgie, Ho\u0302pital de Hautepierre, CHRU Strasbourg, France","institution_ids":["https://openalex.org/I4210157127"]},{"raw_affiliation_string":"Service de Neurochirurgie, H\u00f4pital de Hautepierre, CHRU Strasbourg, France","institution_ids":["https://openalex.org/I4210157127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053031492","display_name":"Dominique Bonnet","orcid":"https://orcid.org/0000-0002-8252-9199","observed_orcids":["https://orcid.org/0000-0002-8252-9199","https://orcid.org/0000-0001-8608-5882"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210116974","display_name":"Laboratoire d'Innovation Th\u00e9rapeutique","ror":"https://ror.org/02g4mxc89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Bonnet","raw_affiliation_strings":["Universite\u0301 de Strasbourg, LIT, CNRS UMR 7200, Illkirch, France","Universit\u00e9 de Strasbourg, LIT, CNRS UMR 7200, Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite\u0301 de Strasbourg, LIT, CNRS UMR 7200, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, LIT, CNRS UMR 7200, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210116974","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102755883","display_name":"Sophie Pinel","orcid":"https://orcid.org/0000-0003-2353-8631","observed_orcids":["https://orcid.org/0000-0003-2353-8631"]},"institutions":[{"id":"https://openalex.org/I4405264217","display_name":"Universit\u00e9 Henri Poincar\u00e9","ror":"https://ror.org/019wrwh65","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405264217","https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Pinel","raw_affiliation_strings":["Universite\u0301 Henri Poincare\u0301, Vandoeuvre les Nancy, France","Universit\u00e9 Henri Poincar\u00e9, Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite\u0301 Henri Poincare\u0301, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I4405264217"]},{"raw_affiliation_string":"Universit\u00e9 Henri Poincar\u00e9, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I4405264217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088206810","display_name":"Fran\u00e7ois Pl\u00e9nat","orcid":"https://orcid.org/0000-0002-9295-9977","observed_orcids":["https://orcid.org/0000-0002-9295-9977"]},"institutions":[{"id":"https://openalex.org/I4405264217","display_name":"Universit\u00e9 Henri Poincar\u00e9","ror":"https://ror.org/019wrwh65","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405264217","https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Plenat","raw_affiliation_strings":["Universite\u0301 Henri Poincare\u0301, Vandoeuvre les Nancy, France","Universit\u00e9 Henri Poincar\u00e9, Vandoeuvre les Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite\u0301 Henri Poincare\u0301, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I4405264217"]},{"raw_affiliation_string":"Universit\u00e9 Henri Poincar\u00e9, Vandoeuvre les Nancy, France","institution_ids":["https://openalex.org/I4405264217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007701213","display_name":"Pascal B. Chastagner","orcid":"https://orcid.org/0000-0002-9134-5797","observed_orcids":["https://orcid.org/0000-0002-9134-5797"]},"institutions":[{"id":"https://openalex.org/I4210100260","display_name":"Centre Hospitalier R\u00e9gional et Universitaire de Nancy","ror":"https://ror.org/016ncsr12","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100260"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Chastagner","raw_affiliation_strings":["CHU Nancy, Vandoeuvre les Nancy, Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU Nancy, Vandoeuvre les Nancy, Nancy, France","institution_ids":["https://openalex.org/I4210100260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080479183","display_name":"Monique Dontenwill","orcid":"https://orcid.org/0000-0002-5235-3014","observed_orcids":["https://orcid.org/0000-0002-5235-3014"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405257448","display_name":"Laboratoire de bioimagerie et pathologies","ror":"https://ror.org/059g0vd42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Monique Dontenwill","raw_affiliation_strings":["Universite\u0301 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universite\u0301 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101626257","display_name":"Sophie Martin","orcid":"https://orcid.org/0000-0002-2907-7445","observed_orcids":["https://orcid.org/0000-0002-2907-7445","https://orcid.org/0009-0003-9985-5622","https://orcid.org/0000-0002-4458-7582"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4405257448","display_name":"Laboratoire de bioimagerie et pathologies","ror":"https://ror.org/059g0vd42","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sophie Martin","raw_affiliation_strings":["Tel.: 0033368854197,","Universite\u0301 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel.: 0033368854197,","institution_ids":[]},{"raw_affiliation_string":"Universite\u0301 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]},{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5101626257"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405257448","https://openalex.org/I68947357"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":1.0487,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.71302173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"131","issue":"3","first_page":"601","last_page":"611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/integrin-alpha5beta1","display_name":"alpha5beta1 integrin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8849999904632568},{"id":"https://openalex.org/keywords/integrin-antagonists","display_name":"integrin antagonists","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.7429999709129333},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2780870201","wikidata":"https://www.wikidata.org/wiki/Q17855958","display_name":"Caveolin 1","level":2,"score":0.8273073434829712},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8047711849212646},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5667802095413208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.529324471950531},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.5253317356109619},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.498410701751709},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35156863927841187},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2953968346118927},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08289021253585815}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D039081","descriptor_name":"Integrin alpha5beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/ijc.26415","doi":"https://doi.org/10.1002/ijc.26415","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.26415","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:21901744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21901744","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00705319v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00705319","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Cancer, 2012, 131, pp.601-611","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-00746869v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00746869","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Cancer, 2012, 131 (3), pp.601-611. ⟨10.1002/ijc.26415⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-00747894v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00747894","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2\u00e8me Colloque Inter-r\u00e9gional Grand-Est de Recherche Translationnelle en Oncologie, ONCOTRANS 2011, Sep 2011, Nancy, France","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1247235447","https://openalex.org/W1525488707","https://openalex.org/W1597188330","https://openalex.org/W1793647354","https://openalex.org/W1967329455","https://openalex.org/W1977122455","https://openalex.org/W1989076816","https://openalex.org/W1992888389","https://openalex.org/W1999454141","https://openalex.org/W2019097505","https://openalex.org/W2022415270","https://openalex.org/W2026836958","https://openalex.org/W2036998931","https://openalex.org/W2042720195","https://openalex.org/W2052824223","https://openalex.org/W2063897621","https://openalex.org/W2069642304","https://openalex.org/W2077502678","https://openalex.org/W2077518066","https://openalex.org/W2083163414","https://openalex.org/W2088261391","https://openalex.org/W2088542790","https://openalex.org/W2092939107","https://openalex.org/W2105164395","https://openalex.org/W2105505534","https://openalex.org/W2107277218","https://openalex.org/W2110094917","https://openalex.org/W2110385921","https://openalex.org/W2118769864","https://openalex.org/W2127936483","https://openalex.org/W2137344766","https://openalex.org/W2139063456","https://openalex.org/W2141055671","https://openalex.org/W2148894332","https://openalex.org/W2150823776","https://openalex.org/W2157078091","https://openalex.org/W2159391262","https://openalex.org/W2160013707","https://openalex.org/W2160363170","https://openalex.org/W2169337864","https://openalex.org/W2182066875","https://openalex.org/W4296241411"],"related_works":["https://openalex.org/W2736906140","https://openalex.org/W2019097505","https://openalex.org/W7027303310","https://openalex.org/W4308943678","https://openalex.org/W2082463969","https://openalex.org/W3194352153","https://openalex.org/W2059055388","https://openalex.org/W2110107397","https://openalex.org/W2896671924","https://openalex.org/W2087968581"],"abstract_inverted_index":{"Caveolin-1":[0,51],"plays":[1],"a":[2,25,55,86,153,159,222,232],"crucial":[3],"role":[4],"in":[5,69,97,119],"the":[6,39,47,71,112,115,122,133,139,149,211,226],"development":[7],"of":[8,22,41,49,58,108,114,124,136,142,177,182,191,196,216,225,234],"cancer":[9],"and":[10,82,91,99,146,158,166,186,200],"its":[11],"progression.":[12],"We":[13,104,128],"previously":[14],"reported":[15],"that":[16,106,130],"glioblastoma":[17,168],"cells":[18,30,131],"expressing":[19,31,132],"low":[20,175,194],"levels":[21,135,141,176,181,190,195],"caveolin-1":[23,76,90,109,137,178,192,204],"exerted":[24],"more":[26],"aggressive":[27],"phenotype":[28,35],"than":[29],"high":[32,180,189],"levels.":[33],"Such":[34],"was":[36,52,65],"due":[37],"to":[38,46,67,83,111,152],"induction":[40],"\u03b1(5)":[42,59,78,92,125,143,154,183,197,206],"\u03b2(1)":[43,60,79,93,126,144,155,184,198,207,218,238],"integrin":[44,80,156,185,199,208,239],"subsequent":[45],"depletion":[48,107],"caveolin-1.":[50],"identified":[53],"as":[54,229,231],"transcriptional":[56],"repressor":[57],"integrin.":[61],"The":[62,214],"current":[63],"study":[64],"designed":[66],"identify":[68],"vitro,":[70],"molecular":[72],"mechanisms":[73],"by":[74],"which":[75,118],"controls":[77,205],"expression":[81,123,209],"determine":[84],"if":[85],"negative":[87],"correlation":[88],"between":[89],"integrins":[94,145],"also":[95],"exists":[96],"biopsies":[98,165],"xenografted":[100],"human":[101,163,167],"brain":[102],"tumors.":[103],"showed":[105,129],"lead":[110],"activation":[113],"TGF\u03b2/TGF\u03b2RI/Smad2":[116,212],"pathway":[117],"turn":[120],"induced":[121],"integrins.":[127],"lowest":[134],"but":[138,179,193],"highest":[140],"TGF\u03b2RI":[147,160,187],"were":[148],"most":[150],"sensitive":[151],"antagonist":[157],"inhibitor.":[161],"Screening":[162],"glioma":[164],"xenografts,":[169],"we":[170],"isolated":[171],"subgroups":[172],"with":[173],"either":[174],"or":[188,236],"TGF\u03b2RI.":[201],"In":[202],"conclusion,":[203],"through":[210],"pathway.":[213],"status":[215],"caveolin-1/\u03b1(5)":[217],"integrins/TGF\u03b2RI":[219],"might":[220],"be":[221],"useful":[223],"marker":[224],"tumor":[227],"evolution/prognosis":[228],"well":[230],"predictor":[233],"anti-TGF\u03b2":[235],"anti-\u03b1(5)":[237],"therapies.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}