{"id":"https://openalex.org/W1978428811","doi":"https://doi.org/10.1073/pnas.0810110106","title":"Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells","display_name":"Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells","publication_year":2009,"publication_date":"2009-02-14","ids":{"openalex":"https://openalex.org/W1978428811","doi":"https://doi.org/10.1073/pnas.0810110106","mag":"1978428811","pmid":"https://pubmed.ncbi.nlm.nih.gov/19218444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2642669"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0810110106","doi":"https://doi.org/10.1073/pnas.0810110106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0810110106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2642669","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011348912","display_name":"Shingo Hatakeyama","orcid":"https://orcid.org/0000-0002-0026-4079","observed_orcids":["https://orcid.org/0000-0002-0026-4079"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shingo Hatakeyama","raw_affiliation_strings":["Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100819307","display_name":"Kazuhiro Sugihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13491362","display_name":"Hamamatsu University","ror":"https://ror.org/057vy9683","country_code":"JP","type":"education","lineage":["https://openalex.org/I13491362"]},{"id":"https://openalex.org/I3123035732","display_name":"Hamamatsu University School of Medicine","ror":"https://ror.org/00ndx3g44","country_code":"JP","type":"education","lineage":["https://openalex.org/I3123035732"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Sugihara","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan;","institution_ids":["https://openalex.org/I13491362","https://openalex.org/I3123035732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105515724","display_name":"Jun Nakayama","orcid":"https://orcid.org/0000-0001-6773-2802","observed_orcids":["https://orcid.org/0000-0001-6773-2802"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nakayama","raw_affiliation_strings":["Department of Pathology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan;","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042124203","display_name":"Tomoya O. Akama","orcid":"https://orcid.org/0000-0003-4248-6929","observed_orcids":["https://orcid.org/0000-0003-4248-6929"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoya O. Akama","raw_affiliation_strings":["Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048247580","display_name":"Shuk-Man Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuk-Man Annie Wong","raw_affiliation_strings":["Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086640700","display_name":"Hiroto Kawashima","orcid":"https://orcid.org/0000-0002-6599-7329","observed_orcids":["https://orcid.org/0000-0002-6599-7329"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroto Kawashima","raw_affiliation_strings":["Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771241","display_name":"Jianing Zhang","orcid":"https://orcid.org/0000-0002-4514-9197","observed_orcids":["https://orcid.org/0000-0002-4514-9197","https://orcid.org/0009-0008-8382-0763"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianing Zhang","raw_affiliation_strings":["Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian 116044, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian 116044, China;","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101527432","display_name":"David F. Smith","orcid":"https://orcid.org/0000-0002-2204-849X","observed_orcids":["https://orcid.org/0000-0002-2204-849X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Smith","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA 30322; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA 30322; and","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076273759","display_name":"Chikara \u039fhyama","orcid":"https://orcid.org/0000-0003-1550-8379","observed_orcids":["https://orcid.org/0000-0003-1550-8379"]},"institutions":[{"id":"https://openalex.org/I146516829","display_name":"Hirosaki University","ror":"https://ror.org/02syg0q74","country_code":"JP","type":"education","lineage":["https://openalex.org/I146516829"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikara Ohyama","raw_affiliation_strings":["Department of Urology, Hirosaki University School of Medicine, Hirosaki 036-8560, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Hirosaki University School of Medicine, Hirosaki 036-8560, Japan","institution_ids":["https://openalex.org/I146516829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107824896","display_name":"Minoru Fukuda","orcid":"https://orcid.org/0000-0002-5321-1843","observed_orcids":["https://orcid.org/0000-0002-5321-1843"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minoru Fukuda","raw_affiliation_strings":["Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006762365","display_name":"Michiko N. Fukuda","orcid":"https://orcid.org/0000-0003-4120-0490","observed_orcids":["https://orcid.org/0000-0003-4120-0490"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michiko N. Fukuda","raw_affiliation_strings":["Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","Washington University School of Medicine, St. Louis, MO,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Microenvironment Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037;","institution_ids":["https://openalex.org/I188891513"]},{"raw_affiliation_string":"Washington University School of Medicine, St. Louis, MO,","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5006762365"],"corresponding_institution_ids":["https://openalex.org/I188891513","https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":2.7499,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.90653176,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"106","issue":"9","first_page":"3095","last_page":"3100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.753000020980835},{"id":"https://openalex.org/keywords/lung-colonization","display_name":"lung colonization","score":0.7250000238418579},{"id":"https://openalex.org/keywords/pulmonary-endothelial-cells","display_name":"pulmonary endothelial cells","score":0.5619999766349792},{"id":"https://openalex.org/keywords/sialyl-lewis-x","display_name":"sialyl Lewis X","score":0.8399999737739563},{"id":"https://openalex.org/keywords/fucosylated-oligosaccharides","display_name":"fucosylated oligosaccharides","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cancer-cell-homing","display_name":"cancer cell homing","score":0.6690000295639038},{"id":"https://openalex.org/keywords/epithelial-cancers","display_name":"epithelial cancers","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6370481848716736},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5081882476806641},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5047343969345093},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4458169937133789},{"id":"https://openalex.org/C2777119779","wikidata":"https://www.wikidata.org/wiki/Q963278","display_name":"Molecular mimicry","level":3,"score":0.4439539909362793},{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.4204506278038025},{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.4138079285621643},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41127967834472656},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35888898372650146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.317413866519928},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.2721577286720276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18736910820007324},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050260","descriptor_name":"Carbohydrate Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0810110106","doi":"https://doi.org/10.1073/pnas.0810110106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0810110106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2642669","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2642669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:19218444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19218444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2642669","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2642669","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2483123008","display_name":null,"funder_award_id":"GM 62116","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4769595620","display_name":"Analysis of single nucleotide polymorphisms of glycosyltransferase gene responsible for the biosysnthesis of gastric\u03bf-glycans and its significance for genetic factor involved in the development of gastric diseases","funder_award_id":"21390104","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6478412656","display_name":"Carbohydrate-Dependent Adhesion in Normal and Tumor Cells","funder_award_id":"P01CA071932","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8305741793","display_name":"Analysis of molecular mechanisms underlying lymphocyte homing using high endothelial venule-specific conditional knockout mice","funder_award_id":"21390023","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8855295916","display_name":"Protein Carbohydrate Interactions in Cell Communication","funder_award_id":"U54GM062116","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8942057748","display_name":"Targeted drug delivery to tumor endothelial surface.","funder_award_id":"20390433","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G9000208973","display_name":null,"funder_award_id":"GM62116","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310760","display_name":"Uehara Memorial Foundation","ror":"https://ror.org/00gc20a07"},{"id":"https://openalex.org/F4320325456","display_name":"Princess Takamatsu Cancer Research Fund","ror":"https://ror.org/00q3q5393"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1485026692","https://openalex.org/W1499936413","https://openalex.org/W1518565669","https://openalex.org/W1525547098","https://openalex.org/W1559177183","https://openalex.org/W1593656349","https://openalex.org/W1604171254","https://openalex.org/W1638424324","https://openalex.org/W1639806955","https://openalex.org/W1664827751","https://openalex.org/W1801936231","https://openalex.org/W1853590226","https://openalex.org/W1947496848","https://openalex.org/W1980434442","https://openalex.org/W1987640672","https://openalex.org/W1995243908","https://openalex.org/W1996100284","https://openalex.org/W1996871080","https://openalex.org/W2001475156","https://openalex.org/W2005992535","https://openalex.org/W2008545486","https://openalex.org/W2010980655","https://openalex.org/W2024286324","https://openalex.org/W2028335218","https://openalex.org/W2032721644","https://openalex.org/W2045841089","https://openalex.org/W2048755413","https://openalex.org/W2075604578","https://openalex.org/W2076692692","https://openalex.org/W2079844004","https://openalex.org/W2084469870","https://openalex.org/W2092366883","https://openalex.org/W2094415450","https://openalex.org/W2129232972","https://openalex.org/W2130389715","https://openalex.org/W2131492616","https://openalex.org/W2131545125","https://openalex.org/W2131688160","https://openalex.org/W2136644692","https://openalex.org/W2136715985","https://openalex.org/W2140336796","https://openalex.org/W2155820414","https://openalex.org/W2159115547","https://openalex.org/W2160942082","https://openalex.org/W2170200613","https://openalex.org/W2171677744","https://openalex.org/W2298229328","https://openalex.org/W2339240706","https://openalex.org/W4244485461"],"related_works":["https://openalex.org/W80679021","https://openalex.org/W1593656349","https://openalex.org/W2134835093","https://openalex.org/W7100840030","https://openalex.org/W2091627905","https://openalex.org/W2131545125","https://openalex.org/W3176109449","https://openalex.org/W2915635119","https://openalex.org/W2120387205","https://openalex.org/W2166842799"],"abstract_inverted_index":{"Cell":[0],"surfaces":[1],"of":[2,41,71,91,140,161,168,175,197],"epithelial":[3,198],"cancer":[4,22],"are":[5,190],"covered":[6],"by":[7,78,97,103],"complex":[8],"carbohydrates,":[9],"whose":[10],"structures":[11],"function":[12],"in":[13,47,79,143,178,180],"malignancy":[14],"and":[15,115,146],"metastasis.":[16],"However,":[17],"the":[18,85,172,181],"mechanism":[19],"underlying":[20],"carbohydrate-dependent":[21,38,194],"metastasis":[23,196],"has":[24],"not":[25,128],"been":[26],"defined.":[27],"Previously,":[28],"we":[29,75],"identified":[30,102],"a":[31,89,138,159],"carbohydrate-mimicry":[32],"peptide":[33],"designated":[34,62],"I-peptide,":[35],"which":[36,82],"inhibits":[37],"lung":[39,54,69,162,173,195],"colonization":[40,70,174],"sialyl":[42],"Lewis":[43],"X-expressing":[44],"B16-FTIII-M":[45,72,125,176],"cells":[46,56,126,177],"E/P-selectin":[48],"doubly-deficient":[49],"mice.":[50],"We":[51],"hypothesized":[52],"that":[53,84,187],"endothelial":[55],"express":[57],"an":[58],"unknown":[59],"carbohydrate":[60],"receptor,":[61],"as":[63,105],"I-peptide":[64,98],"receptor":[65],"(IPR),":[66],"responsible":[67,191],"for":[68,192],"cells.":[73,132],"Here,":[74],"visualized":[76],"IPR":[77,87,94],"vivo":[80,179],"biotinylation,":[81],"revealed":[83],"major":[86],"is":[88],"group":[90],"35-kDa":[92],"proteins.":[93],"proteins":[95,189],"isolated":[96],"affinity":[99],"chromatography":[100],"were":[101,152],"proteomics":[104],"Ser/Arg-rich":[106],"alternative":[107],"pre-mRNA":[108],"splicing":[109],"factors":[110],"or":[111],"Sfrs1,":[112],"Sfrs2,":[113],"Sfrs5,":[114],"Sfrs7":[116],"gene":[117],"products.":[118],"Bacterially":[119],"expressed":[120],"Sfrs1":[121,134],"protein":[122,135],"bound":[123,136],"to":[124,129,137,171],"but":[127],"parental":[130],"B16":[131],"Recombinant":[133],"series":[139],"fucosylated":[141,193],"oligosaccharides":[142],"glycan":[144],"array":[145],"plate-binding":[147],"assays.":[148],"When":[149],"anti-Sfrs":[150],"antibodies":[151,157,165],"injected":[153],"intravenously":[154],"into":[155],"mice,":[156],"labeled":[158],"subset":[160],"capillaries.":[163],"Anti-Sfrs":[164],"inhibited":[166],"homing":[167],"I-peptide-displaying":[169],"phage":[170],"mouse.":[182],"These":[183],"results":[184],"strongly":[185],"suggest":[186],"Sfrs":[188],"cancers.":[199]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}