{"id":"https://openalex.org/W1978406948","doi":"https://doi.org/10.1074/jbc.m210332200","title":"A Human Topoisomerase II\u03b1 Heterodimer with Only One ATP Binding Site Can Go through Successive Catalytic Cycles","display_name":"A Human Topoisomerase II\u03b1 Heterodimer with Only One ATP Binding Site Can Go through Successive Catalytic Cycles","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W1978406948","doi":"https://doi.org/10.1074/jbc.m210332200","mag":"1978406948","pmid":"https://pubmed.ncbi.nlm.nih.gov/12480934"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m210332200","doi":"https://doi.org/10.1074/jbc.m210332200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m210332200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m210332200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017596980","display_name":"Camilla Skouboe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Camilla Skouboe","raw_affiliation_strings":["Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, Arhus C 8000, Denmark","From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, Arhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015465417","display_name":"Lotte Bjergb\u00e6k","orcid":"https://orcid.org/0000-0002-8233-3356","observed_orcids":["https://orcid.org/0000-0002-8233-3356"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lotte Bjergbaek","raw_affiliation_strings":["From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000722285","display_name":"Vibe H. Oestergaard","orcid":"https://orcid.org/0000-0002-1633-0560","observed_orcids":["https://orcid.org/0000-0002-1633-0560"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Vibe H. Oestergaard","raw_affiliation_strings":["From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040023409","display_name":"Morten Kob\u00e6k-Larsen","orcid":"https://orcid.org/0000-0002-5097-9283","observed_orcids":["https://orcid.org/0000-0002-5097-9283"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten K. Larsen","raw_affiliation_strings":["From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080879530","display_name":"Birgitta Ruth Knudsen","orcid":"https://orcid.org/0000-0002-3484-3802","observed_orcids":["https://orcid.org/0000-0002-3484-3802"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Birgitta R. Knudsen","raw_affiliation_strings":["From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014731222","display_name":"Anni Hangaard Andersen","orcid":"https://orcid.org/0000-0001-7194-3258","observed_orcids":["https://orcid.org/0000-0001-7194-3258"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Anni H. Andersen","raw_affiliation_strings":["From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers Alle\u0301, Building 130, \u212brhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"From the Department of Molecular Biology, University of Aarhus, C. F. M\u00f8llers All\u00e9, Building 130, \u00c5rhus C 8000, Denmark","institution_ids":["https://openalex.org/I204337017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014731222"],"corresponding_institution_ids":["https://openalex.org/I204337017"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.6514,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.59604672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"278","issue":"8","first_page":"5768","last_page":"5774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/topoisomerase-ii-alpha","display_name":"TOP2A","score":0.9679999947547913},{"id":"https://openalex.org/keywords/topoisomerase-ii","display_name":"topoisomerase II","score":0.8130000233650208},{"id":"https://openalex.org/keywords/heterodimer","display_name":"heterodimer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/atp-binding-site","display_name":"ATP binding site","score":0.8519999980926514},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/dna-strand-passage","display_name":"DNA strand passage","score":0.8299999833106995},{"id":"https://openalex.org/keywords/supercoiled-dna-relaxation","display_name":"supercoiled DNA relaxation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/icrf-187","display_name":"ICRF-187","score":0.9900000095367432},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.7689999938011169},{"id":"https://openalex.org/keywords/dna-cleavage","display_name":"DNA cleavage","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C158456008","wikidata":"https://www.wikidata.org/wiki/Q412639","display_name":"DNA supercoil","level":4,"score":0.7533175945281982},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.6949455738067627},{"id":"https://openalex.org/C141315368","wikidata":"https://www.wikidata.org/wiki/Q4654881","display_name":"ATP hydrolysis","level":4,"score":0.6945891976356506},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6898579597473145},{"id":"https://openalex.org/C58167604","wikidata":"https://www.wikidata.org/wiki/Q5121654","display_name":"Circular bacterial chromosome","level":4,"score":0.5977814793586731},{"id":"https://openalex.org/C31254050","wikidata":"https://www.wikidata.org/wiki/Q22328799","display_name":"DNA clamp","level":5,"score":0.5363285541534424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5221041440963745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4439879059791565},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4266946017742157},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3905262351036072},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3881026804447174},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3242757320404053},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.32083648443222046},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.2369353175163269},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.1990451216697693},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11127308011054993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07748675346374512},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000266","descriptor_name":"Adenylyl Imidodiphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004250","descriptor_name":"DNA Topoisomerases, Type II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m210332200","doi":"https://doi.org/10.1074/jbc.m210332200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m210332200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:12480934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12480934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/ad224ab7-d634-4bb6-b23e-df6327cc9469","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/ad224ab7-d634-4bb6-b23e-df6327cc9469","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skouboe, C, Bjergbaek, L, Oestergaard, V H, Larsen, M K, Knudsen, B R & Andersen, A H 2003, 'A human topoisomerase II\u03b1 heterodimer with only one ATP binding site can go through successive catalytic cycles', Journal of Biological Chemistry, vol. 278, no. 8, pp. 5768-5774. https://doi.org/10.1074/jbc.M210332200","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/72713a60-b9a0-11da-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/72713a60-b9a0-11da-bee9-02004c4f4f50","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Skouboe, C, Bjergb\u00e6k, L, \u00d8stergaard, V, Larsen, M K, Knudsen, B R & Andersen, A H 2003, 'A human topoisomerase II\u03b1 heterodimer with only one ATP binding site can go through successive catalytic cycles', Journal of Biological Chemistry, vol. 278, pp. 5768-5774.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m210332200","doi":"https://doi.org/10.1074/jbc.m210332200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m210332200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1543261346","https://openalex.org/W1594161662","https://openalex.org/W1595993539","https://openalex.org/W1606546816","https://openalex.org/W1926569414","https://openalex.org/W1978924947","https://openalex.org/W1981123122","https://openalex.org/W1982534799","https://openalex.org/W1983487576","https://openalex.org/W1989600623","https://openalex.org/W1993553978","https://openalex.org/W2002333049","https://openalex.org/W2017742066","https://openalex.org/W2023118185","https://openalex.org/W2031676888","https://openalex.org/W2052759356","https://openalex.org/W2056367986","https://openalex.org/W2060268336","https://openalex.org/W2064348188","https://openalex.org/W2067561398","https://openalex.org/W2071251275","https://openalex.org/W2074538201","https://openalex.org/W2075798168","https://openalex.org/W2089395264","https://openalex.org/W2091856251","https://openalex.org/W2103697542","https://openalex.org/W2107722987","https://openalex.org/W2134200178","https://openalex.org/W2150949795","https://openalex.org/W2341351767","https://openalex.org/W4236530034"],"related_works":["https://openalex.org/W1996721074","https://openalex.org/W2043656081","https://openalex.org/W2091856251","https://openalex.org/W2117554393","https://openalex.org/W2129418158","https://openalex.org/W2002333049","https://openalex.org/W2020211791","https://openalex.org/W2107722987","https://openalex.org/W1606546816","https://openalex.org/W6989449825"],"abstract_inverted_index":{"Eukaryotic":[0],"DNA":[1,11,21,36,79,142,165,180,203],"topoisomerase":[2,89,131],"II":[3,90,132],"is":[4],"a":[5,39,56,87,118,188],"dimeric":[6],"nuclear":[7],"enzyme":[8,53,146],"essential":[9],"for":[10,141],"metabolism":[12],"and":[13,25,50,64,74,85,122,145,150,169,201],"chromosome":[14],"dynamics.":[15],"It":[16,115],"changes":[17],"the":[18,32,48,69,111,138,157,160,174,198,202],"topology":[19],"of":[20,27,34,58,71,152,164,177],"by":[22],"coupling":[23],"binding":[24,73,97,149,168],"hydrolysis":[26,75,151,170],"two":[28],"ATP":[29,72,96,167,178,200],"molecules":[30],"to":[31,78,103,125,205],"transport":[33],"one":[35,95,154],"duplex":[37],"through":[38,55,136],"temporary":[40],"break":[41],"introduced":[42],"in":[43,76,187],"another.":[44],"During":[45],"this":[46],"process":[47],"structurally":[49],"functionally":[51],"complex":[52],"passes":[54],"cascade":[57],"conformational":[59],"changes,":[60],"which":[61],"requires":[62,193],"intra-":[63],"intersubunit":[65],"communication.":[66],"To":[67],"study":[68],"importance":[70],"relation":[77],"strand":[80,143],"transfer,":[81],"we":[82],"have":[83],"purified":[84],"characterized":[86],"human":[88,130],"alpha":[91,133],"heterodimer":[92,100,158],"with":[93,148],"only":[94,153],"site.":[98],"The":[99,182],"was":[101,123],"able":[102],"relax":[104],"supercoiled":[105],"DNA,":[106],"although":[107],"less":[108],"efficiently":[109],"than":[110],"wild":[112],"type":[113],"enzyme.":[114],"furthermore":[116],"possessed":[117],"functional":[119],"N-terminal":[120],"clamp":[121],"sensitive":[124],"ICRF-187.":[126],"This":[127],"demonstrates":[128],"that":[129],"can":[134,184],"pass":[135],"all":[137],"conformations":[139],"required":[140],"passage":[144],"resetting":[147],"ATP.":[155],"However,":[156],"lacked":[159],"normal":[161],"stimulatory":[162,175],"effect":[163,176],"on":[166,179],"as":[171,173],"well":[172],"cleavage.":[181],"results":[183],"be":[185,206],"explained":[186],"model,":[189],"where":[190],"efficient":[191],"catalysis":[192],"an":[194],"extensive":[195],"communication":[196],"between":[197],"second":[199],"segment":[204],"cleaved.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}