{"id":"https://openalex.org/W1978398706","doi":"https://doi.org/10.1016/j.ceb.2005.09.011","title":"The mitotic checkpoint in cancer and aging: what have mice taught us?","display_name":"The mitotic checkpoint in cancer and aging: what have mice taught us?","publication_year":2005,"publication_date":"2005-10-14","ids":{"openalex":"https://openalex.org/W1978398706","doi":"https://doi.org/10.1016/j.ceb.2005.09.011","mag":"1978398706","pmid":"https://pubmed.ncbi.nlm.nih.gov/16226453"},"language":"en","primary_location":{"id":"doi:10.1016/j.ceb.2005.09.011","doi":"https://doi.org/10.1016/j.ceb.2005.09.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ceb.2005.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081893956","display_name":"Darren J. Baker","orcid":"https://orcid.org/0000-0001-9006-1939","observed_orcids":["https://orcid.org/0000-0001-9006-1939"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren J Baker","raw_affiliation_strings":["Department of Pediatric, Mayo Clinic, 200 1st ST SW, Rochester, Minnesota 55905, USA","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric, Mayo Clinic, 200 1st ST SW, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365539","display_name":"Junjie Chen","orcid":"https://orcid.org/0000-0002-1493-2189","observed_orcids":["https://orcid.org/0000-0002-1493-2189"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junjie Chen","raw_affiliation_strings":["Departments of Pediatric and Adolescent Medicine, Biochemistry and Molecular Biology, Mayo Clinic, 200 1st ST SW, Rochester, Minnesota 55905, USA","Experimental Radiation Oncology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatric and Adolescent Medicine, Biochemistry and Molecular Biology, Mayo Clinic, 200 1st ST SW, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Experimental Radiation Oncology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110099202","display_name":"Jan M. A. van Deursen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jan MA van Deursen","raw_affiliation_strings":["Departments of Pediatric and Adolescent Medicine, Biochemistry and Molecular Biology, Mayo Clinic, 200 1st ST SW, Rochester, Minnesota 55905, USA","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatric and Adolescent Medicine, Biochemistry and Molecular Biology, Mayo Clinic, 200 1st ST SW, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110099202"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.7245,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.53592233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"6","first_page":"583","last_page":"589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6389999985694885},{"id":"https://openalex.org/keywords/bubr1","display_name":"BubR1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C175732170","wikidata":"https://www.wikidata.org/wiki/Q9064829","display_name":"Spindle checkpoint","level":5,"score":0.9121822118759155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8191919326782227},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.7192513346672058},{"id":"https://openalex.org/C2778354886","wikidata":"https://www.wikidata.org/wiki/Q5113927","display_name":"Chromosome segregation","level":4,"score":0.7054550051689148},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7007326483726501},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.6962020397186279},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.6631706357002258},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.515238344669342},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.4958833158016205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4424445331096649},{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.43481236696243286},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4115482568740845},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4020848572254181},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39400169253349304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39287811517715454},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.3899044692516327},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2797504961490631},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22596290707588196},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.20566925406455994},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1478540301322937}],"mesh":[{"descriptor_ui":"D000075223","descriptor_name":"Poly-ADP-Ribose Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018816","descriptor_name":"Genes, cdc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ceb.2005.09.011","doi":"https://doi.org/10.1016/j.ceb.2005.09.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ceb.2005.09.011","pdf_url":null,"source":{"id":"https://openalex.org/S103771297","display_name":"Current Opinion in Cell Biology","issn_l":"0955-0674","issn":["0955-0674","1879-0410"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Cell Biology","raw_type":"journal-article"},{"id":"pmid:16226453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16226453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4928858768","display_name":"Nucleoporins in Chromosomal Instability and Cancer","funder_award_id":"R01CA077262","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8623854477","display_name":"BubRI in Cancer and Aging","funder_award_id":"R01CA096985","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W176308265","https://openalex.org/W1488719611","https://openalex.org/W1966122738","https://openalex.org/W1966388369","https://openalex.org/W1967085988","https://openalex.org/W1968332958","https://openalex.org/W1970378023","https://openalex.org/W1970511605","https://openalex.org/W1972142265","https://openalex.org/W1974319312","https://openalex.org/W1974773964","https://openalex.org/W1979765208","https://openalex.org/W1984542357","https://openalex.org/W1985483785","https://openalex.org/W1989478892","https://openalex.org/W1995405908","https://openalex.org/W1997937385","https://openalex.org/W2007105351","https://openalex.org/W2007388359","https://openalex.org/W2011112706","https://openalex.org/W2016766601","https://openalex.org/W2017798817","https://openalex.org/W2021080183","https://openalex.org/W2022527641","https://openalex.org/W2022572059","https://openalex.org/W2025216788","https://openalex.org/W2025418498","https://openalex.org/W2036012693","https://openalex.org/W2038696352","https://openalex.org/W2039517468","https://openalex.org/W2062102664","https://openalex.org/W2062117947","https://openalex.org/W2075194761","https://openalex.org/W2084567406","https://openalex.org/W2102653975","https://openalex.org/W2106285650","https://openalex.org/W2107123200","https://openalex.org/W2109245114","https://openalex.org/W2114460232","https://openalex.org/W2115275371","https://openalex.org/W2116376484","https://openalex.org/W2116483507","https://openalex.org/W2118562565","https://openalex.org/W2118676790","https://openalex.org/W2121880894","https://openalex.org/W2123058467","https://openalex.org/W2123154779","https://openalex.org/W2127926172","https://openalex.org/W2133469432","https://openalex.org/W2138968849","https://openalex.org/W2140656629","https://openalex.org/W2144140175","https://openalex.org/W2145339783","https://openalex.org/W2153198916","https://openalex.org/W2169453999","https://openalex.org/W2188033081","https://openalex.org/W2415418914"],"related_works":["https://openalex.org/W2096000713","https://openalex.org/W2154428950","https://openalex.org/W2145339783","https://openalex.org/W2063681000","https://openalex.org/W1966122738","https://openalex.org/W2094375019","https://openalex.org/W1979765208","https://openalex.org/W1491564077","https://openalex.org/W2012399364","https://openalex.org/W91173669"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
