{"id":"https://openalex.org/W1978386922","doi":"https://doi.org/10.1111/j.1399-3011.1997.tb01469.x","title":"Structure\u2010antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A\u2010magainin 2 and cecropin A\u2010melittin hybrid peptides","display_name":"Structure\u2010antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A\u2010magainin 2 and cecropin A\u2010melittin hybrid peptides","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W1978386922","doi":"https://doi.org/10.1111/j.1399-3011.1997.tb01469.x","mag":"1978386922","pmid":"https://pubmed.ncbi.nlm.nih.gov/9352466"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-3011.1997.tb01469.x","doi":"https://doi.org/10.1111/j.1399-3011.1997.tb01469.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3011.1997.tb01469.x","pdf_url":null,"source":{"id":"https://openalex.org/S122310368","display_name":"Journal of Peptide Research","issn_l":"1397-002X","issn":["1397-002X","1399-3011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Peptide Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036123454","display_name":"Song Yub Shin","orcid":"https://orcid.org/0000-0002-3030-7973","observed_orcids":["https://orcid.org/0000-0002-3030-7973"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SONG YUB SHIN","raw_affiliation_strings":["Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001295371","display_name":"Myung Kyu Lee","orcid":"https://orcid.org/0000-0003-1419-9631","observed_orcids":["https://orcid.org/0000-0003-1419-9631"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"MYUNG KYU LEE","raw_affiliation_strings":["Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, P.O. Box 115, Yusong, Taejon 305-600, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, P.O. Box 115, Yusong, Taejon 305-600, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019832639","display_name":"Kil Lyong Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"KIL LYONG KIM","raw_affiliation_strings":["Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, P.O. Box 115, Yusong, Taejon 305-600, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, P.O. Box 115, Yusong, Taejon 305-600, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110017622","display_name":"Kyung\u2010Soo Hahm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"KYUNG\u2010SOO HAHM","raw_affiliation_strings":["Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, P.O. Box 115, Yusong, Taejon 305-600, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, KIST, P.O. Box 115, Yusong, Taejon 305-600, Korea","institution_ids":["https://openalex.org/I73616290"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110017622"],"corresponding_institution_ids":["https://openalex.org/I73616290"],"apc_list":null,"apc_paid":null,"fwci":2.2118,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.86425073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"50","issue":"4","first_page":"279","last_page":"285"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cecropin-a","display_name":"cecropin A","score":0.9179999828338623},{"id":"https://openalex.org/keywords/magainin-2","display_name":"magainin 2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/melittin","display_name":"melittin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hybrid-peptides","display_name":"hybrid peptides","score":0.7409999966621399},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7509999871253967},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.902999997138977},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8140000104904175},{"id":"https://openalex.org/keywords/amphipathicity","display_name":"amphipathicity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/alpha-helix","display_name":"alpha-helix","score":0.8050000071525574},{"id":"https://openalex.org/keywords/peptide-hydrophobicity","display_name":"peptide hydrophobicity","score":0.5649999976158142},{"id":"https://openalex.org/keywords/antimalarial-activity","display_name":"antimalarial activity","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2778001312","wikidata":"https://www.wikidata.org/wiki/Q424512","display_name":"Melittin","level":3,"score":0.959091067314148},{"id":"https://openalex.org/C2778553168","wikidata":"https://www.wikidata.org/wiki/Q6729606","display_name":"Magainin","level":4,"score":0.8929004669189453},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.766755998134613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6220787167549133},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.5475854873657227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5264699459075928},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.4151213467121124},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2612142264842987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21915093064308167},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.18390628695487976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08748659491539001}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008555","descriptor_name":"Melitten","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008555","descriptor_name":"Melitten","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054806","descriptor_name":"Magainins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1399-3011.1997.tb01469.x","doi":"https://doi.org/10.1111/j.1399-3011.1997.tb01469.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-3011.1997.tb01469.x","pdf_url":null,"source":{"id":"https://openalex.org/S122310368","display_name":"Journal of Peptide Research","issn_l":"1397-002X","issn":["1397-002X","1399-3011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Peptide Research","raw_type":"journal-article"},{"id":"pmid:9352466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9352466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of peptide research : official journal of the American Peptide Society","raw_type":"Journal Article"},{"id":"pmh:oai:http://repository.kribb.re.kr:8080/:201005/4199","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/201005/4199","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/1841.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/4199","doi":null,"is_oa":false,"landing_page_url":"https://repository.kribb.re.kr/handle/201005/4199","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/1841.pdf","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1706613099","https://openalex.org/W1919212472","https://openalex.org/W1970621669","https://openalex.org/W1978873580","https://openalex.org/W1994567110","https://openalex.org/W1998084493","https://openalex.org/W2005902468","https://openalex.org/W2014035436","https://openalex.org/W2018984543","https://openalex.org/W2024220427","https://openalex.org/W2058570720","https://openalex.org/W2061764021","https://openalex.org/W2068221306","https://openalex.org/W2069282930","https://openalex.org/W2079468421","https://openalex.org/W2100310215","https://openalex.org/W2105954841","https://openalex.org/W2136906409","https://openalex.org/W2161522041","https://openalex.org/W2179142653","https://openalex.org/W2265126036"],"related_works":["https://openalex.org/W2143224430","https://openalex.org/W2180350453","https://openalex.org/W2077317230","https://openalex.org/W7064087514","https://openalex.org/W7055812527","https://openalex.org/W2406590354","https://openalex.org/W2018984543","https://openalex.org/W6989756810","https://openalex.org/W1903359148","https://openalex.org/W1997560226"],"abstract_inverted_index":{"The":[0,82,121],"hybrid":[1],"peptide":[2,70],"(CA-ME)":[3],"derived":[4],"from":[5],"cecropin":[6],"A(1-8)":[7],"and":[8,14,32,34,39,66,78],"melittin":[9],"(1-12)":[10],"has":[11],"potent":[12],"antibacterial":[13],"antimalarial":[15],"activities.":[16],"Because":[17],"the":[18,62,69,86,89,124],"N-terminal":[19],"sequence":[20],"1-12":[21],"of":[22,43,68,85,110,123],"magainin":[23],"2":[24,92],"is":[25],"similar":[26],"to":[27,93,100,138],"melittin(1-12),":[28],"CA-MA":[29],"with":[30,88],"CA(1-8)":[31],"MA(1-12)":[33],"their":[35],"analogues":[36],"were":[37,46,71,91],"designed":[38],"synthesized.":[40],"Antitumor":[41],"activities":[42],"these":[44],"peptides":[45,87,125],"evaluated":[47],"using":[48],"three":[49],"small":[50],"cell":[51,54],"lung":[52],"cancer":[53],"lines.":[55],"Greater":[56],"antitumor":[57,105,119,142],"activity":[58,102,114,140],"was":[59,98,134],"observed":[60],"when":[61],"residues":[63,90],"16,":[64],"18":[65],"19":[67],"hydrophobic":[72],"(Leu":[73],"or":[74],"Val),":[75],"basic":[76,79],"(Lys)":[77],"(Lys),":[80],"respectively.":[81],"IC50":[83],"values":[84],"4":[94],"microM.":[95],"Residue":[96],"12":[97],"related":[99],"hemolytic":[101,113,139],"rather":[103],"than":[104,141],"activity.":[106,120,143],"Increase":[107],"in":[108,118,126],"amphipathicity":[109],"P4":[111],"enhanced":[112],"without":[115],"significant":[116],"change":[117],"alpha-helicity":[122],"a":[127],"30":[128],"mM":[129],"sodium":[130],"dodecyl":[131],"sulfate":[132],"solution":[133],"more":[135],"closely":[136],"correlated":[137]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
