{"id":"https://openalex.org/W1978384513","doi":"https://doi.org/10.4161/cc.7.14.6423","title":"Cell cycle regulation in hair cell development and regeneration in the mouse cochlea","display_name":"Cell cycle regulation in hair cell development and regeneration in the mouse cochlea","publication_year":2008,"publication_date":"2008-07-15","ids":{"openalex":"https://openalex.org/W1978384513","doi":"https://doi.org/10.4161/cc.7.14.6423","mag":"1978384513","pmid":"https://pubmed.ncbi.nlm.nih.gov/18635955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2538578"},"language":"en","primary_location":{"id":"doi:10.4161/cc.7.14.6423","doi":"https://doi.org/10.4161/cc.7.14.6423","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.7.14.6423","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.14.6423?needAccess=true","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.14.6423?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022647005","display_name":"Zhiyong Liu","orcid":"https://orcid.org/0000-0002-9675-1233","observed_orcids":["https://orcid.org/0000-0002-9675-1233"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiyong Liu","raw_affiliation_strings":["Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100657071","display_name":"Jian Zuo","orcid":"https://orcid.org/0000-0002-1448-4507","observed_orcids":["https://orcid.org/0000-0002-1448-4507","https://orcid.org/0009-0007-6278-6335","https://orcid.org/0000-0002-5395-2887"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian Zuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0685,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.84446006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"14","first_page":"2129","last_page":"2133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hair-cell-regeneration","display_name":"hair cell regeneration","score":0.972000002861023},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cell-cycle-inhibitors","display_name":"cell cycle inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cell-cycle-re-entry","display_name":"cell cycle re-entry","score":0.703000009059906},{"id":"https://openalex.org/keywords/supporting-cells","display_name":"supporting cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/transdifferentiation","display_name":"transdifferentiation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.5699999928474426},{"id":"https://openalex.org/keywords/deafness","display_name":"deafness","score":0.5569999814033508},{"id":"https://openalex.org/keywords/mouse-cochlea","display_name":"mouse cochlea","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8767895698547363},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.8378945589065552},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7500923275947571},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.6775983572006226},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6414528489112854},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.5960550308227539},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5704628825187683},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5360313653945923},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.48272082209587097},{"id":"https://openalex.org/C2991961867","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair cycle","level":3,"score":0.4518912434577942},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42418673634529114},{"id":"https://openalex.org/C2776557274","wikidata":"https://www.wikidata.org/wiki/Q7611233","display_name":"Stereocilia (inner ear)","level":4,"score":0.42169997096061707},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4122188687324524},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4107576608657837},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.38335856795310974},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27717500925064087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21917620301246643},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.1609698235988617},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08477213978767395}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006198","descriptor_name":"Hair Cells, Auditory","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4161/cc.7.14.6423","doi":"https://doi.org/10.4161/cc.7.14.6423","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.7.14.6423","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.14.6423?needAccess=true","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmid:18635955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18635955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2538578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2538578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Cycle","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/cc.7.14.6423","doi":"https://doi.org/10.4161/cc.7.14.6423","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.7.14.6423","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.7.14.6423?needAccess=true","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G164415112","display_name":null,"funder_award_id":"DC06471","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G165480143","display_name":"Genetic analysis of mammalian hearing sensitivity","funder_award_id":"R01DC006471","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G2665654987","display_name":"Generation of mice with inducible Cre expression in adult cochlear hair cells","funder_award_id":"R21DC008800","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G4177576686","display_name":null,"funder_award_id":"DC05168","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G5000964654","display_name":"CONDITIONAL GENE TARGETING IN HAIR CELLS","funder_award_id":"R21DC005168","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G609259107","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6298368088","display_name":null,"funder_award_id":"DC008800","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1978384513.pdf"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1479883635","https://openalex.org/W1486122524","https://openalex.org/W1934410218","https://openalex.org/W1971757408","https://openalex.org/W1978034376","https://openalex.org/W1979330829","https://openalex.org/W1990385171","https://openalex.org/W1997399224","https://openalex.org/W1998492363","https://openalex.org/W2001400122","https://openalex.org/W2006655162","https://openalex.org/W2006723548","https://openalex.org/W2008789097","https://openalex.org/W2012708732","https://openalex.org/W2015066175","https://openalex.org/W2024019673","https://openalex.org/W2026004604","https://openalex.org/W2026082491","https://openalex.org/W2027697642","https://openalex.org/W2029689941","https://openalex.org/W2040412126","https://openalex.org/W2044168912","https://openalex.org/W2044947020","https://openalex.org/W2049283940","https://openalex.org/W2059763574","https://openalex.org/W2069610820","https://openalex.org/W2076392163","https://openalex.org/W2085157715","https://openalex.org/W2090807626","https://openalex.org/W2091729097","https://openalex.org/W2098102650","https://openalex.org/W2098157104","https://openalex.org/W2100706309","https://openalex.org/W2105493567","https://openalex.org/W2105881005","https://openalex.org/W2107880845","https://openalex.org/W2116711648","https://openalex.org/W2122317430","https://openalex.org/W2123241263","https://openalex.org/W2124343481","https://openalex.org/W2124725230","https://openalex.org/W2129384667","https://openalex.org/W2140348457","https://openalex.org/W2148209107","https://openalex.org/W2161135924","https://openalex.org/W2165431561","https://openalex.org/W2170024216"],"related_works":["https://openalex.org/W2044168912","https://openalex.org/W2061415467","https://openalex.org/W2003578253","https://openalex.org/W2140348457","https://openalex.org/W2000408922","https://openalex.org/W2069610820","https://openalex.org/W2133067725","https://openalex.org/W2771081905","https://openalex.org/W1971757408","https://openalex.org/W2098365031"],"abstract_inverted_index":{"Cell":[0],"cycle":[1,52,72,140],"inhibitors":[2,141],"play":[3,67],"important":[4],"roles":[5,69],"in":[6,18,25,62,70,87,142,153],"the":[7,45,129],"development":[8],"of":[9,13,15,33,44,57,76,89,94,160],"mammalian":[10,143],"cochleae.":[11],"Loss":[12],"function":[14],"those":[16],"factors":[17],"mice":[19],"at":[20],"various":[21],"developmental":[22],"stages":[23],"results":[24],"distinct":[26],"phenotypes":[27],"characterized":[28],"by":[29,157],"overproduction":[30],"or":[31],"loss":[32,56],"cochlear":[34,59],"sensory":[35],"cells.":[36,100],"Our":[37],"recent":[38],"study":[39],"showed":[40],"that":[41],"acute":[42],"deletion":[43],"retinoblastoma":[46],"protein":[47],"(Rb)":[48],"induces":[49],"rapid":[50],"cell":[51,71,78,81,139],"reentry":[53],"and":[54,74,79,92,98,120,135,163],"subsequent":[55],"postnatal":[58],"hair":[60,77,96,104,126],"cells":[61,97,105,127,132],"mice.":[63],"Clearly,":[64],"these":[65],"regulators":[66],"multiple":[68],"exit":[73],"differentiation":[75],"supporting":[80,99,131],"progenitors.":[82],"They":[83],"are":[84],"also":[85],"crucial":[86],"maintenance":[88],"postmitotic":[90],"states":[91],"survival":[93],"differentiated":[95],"In":[101],"mammals,":[102],"lost":[103],"cannot":[106],"be":[107],"spontaneously":[108],"replaced,":[109],"leading":[110],"to":[111,150],"permanent":[112],"deafness.":[113],"However,":[114],"lower":[115],"vertebrates":[116],"such":[117],"as":[118],"birds":[119],"fish":[121],"can":[122],"naturally":[123],"regenerate":[124],"damaged":[125],"from":[128],"underlying":[130],"through":[133],"proliferation":[134],"transdifferentiation.":[136],"Thus,":[137],"manipulating":[138],"cochleae":[144],"could":[145],"provide":[146],"a":[147,158],"new":[148],"avenue":[149],"restore":[151],"hearing":[152],"deaf":[154],"people":[155],"caused":[156],"variety":[159],"genetic":[161],"mutations":[162],"environmental":[164],"insults.":[165]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}