{"id":"https://openalex.org/W1978364271","doi":"https://doi.org/10.1016/j.ejphar.2004.01.025","title":"Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and \u03b2-adrenergic renal vasodilations","display_name":"Relative roles of endothelial relaxing factors in cyclosporine-induced impairment of cholinergic and \u03b2-adrenergic renal vasodilations","publication_year":2004,"publication_date":"2004-02-25","ids":{"openalex":"https://openalex.org/W1978364271","doi":"https://doi.org/10.1016/j.ejphar.2004.01.025","mag":"1978364271","pmid":"https://pubmed.ncbi.nlm.nih.gov/15033387"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2004.01.025","doi":"https://doi.org/10.1016/j.ejphar.2004.01.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2004.01.025","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045120949","display_name":"Mahmoud M. El\u2010Mas","orcid":"https://orcid.org/0000-0001-8855-7070","observed_orcids":["https://orcid.org/0000-0001-8855-7070"]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"M El-Mas","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. elmasm@mail.ecu.edu","Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. elmasm@mail.ecu.edu","institution_ids":["https://openalex.org/I84524832"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045120949"],"corresponding_institution_ids":["https://openalex.org/I84524832"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.9756,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.74044896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"487","issue":"1-3","first_page":"149","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclosporine","display_name":"cyclosporine","score":0.9480000138282776},{"id":"https://openalex.org/keywords/endothelium-derived-relaxing-factor","display_name":"endothelium-derived relaxing factor","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/endothelium-derived-hyperpolarizing-factor","display_name":"endothelium-derived hyperpolarizing factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.9879999756813049},{"id":"https://openalex.org/keywords/renal-vasodilation","display_name":"renal vasodilation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.8119999766349792},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.722000002861023},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.902999997138977},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.675000011920929},{"id":"https://openalex.org/keywords/tetraethylammonium","display_name":"tetraethylammonium","score":0.8090000152587891},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.671999990940094},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cyclosporine-nephrotoxicity","display_name":"cyclosporine nephrotoxicity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/isolated-perfused-kidney","display_name":"isolated perfused kidney","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2781295685","wikidata":"https://www.wikidata.org/wiki/Q410728","display_name":"Tetraethylammonium","level":3,"score":0.679722011089325},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6662508249282837},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6499800682067871},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6267133355140686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5110653638839722},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5059453845024109},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.49783778190612793},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.4900113642215729},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42665353417396545},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18552657961845398},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.0},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001685","descriptor_name":"Biological Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010275","descriptor_name":"Parasympathetic Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026902","descriptor_name":"Potassium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045462","descriptor_name":"Endothelium-Dependent Relaxing Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejphar.2004.01.025","doi":"https://doi.org/10.1016/j.ejphar.2004.01.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2004.01.025","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:15033387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15033387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1802809803","https://openalex.org/W1958322047","https://openalex.org/W1965180947","https://openalex.org/W1970192183","https://openalex.org/W1975366846","https://openalex.org/W1976432295","https://openalex.org/W1993783817","https://openalex.org/W2005375764","https://openalex.org/W2012616491","https://openalex.org/W2014572617","https://openalex.org/W2015996189","https://openalex.org/W2017140757","https://openalex.org/W2024979890","https://openalex.org/W2025984813","https://openalex.org/W2027309597","https://openalex.org/W2027827865","https://openalex.org/W2048140772","https://openalex.org/W2050718967","https://openalex.org/W2055610437","https://openalex.org/W2062864110","https://openalex.org/W2064212747","https://openalex.org/W2069793993","https://openalex.org/W2074455271","https://openalex.org/W2078678969","https://openalex.org/W2079097007","https://openalex.org/W2091897779","https://openalex.org/W2093285892","https://openalex.org/W2126846811","https://openalex.org/W2161445267","https://openalex.org/W2162253577","https://openalex.org/W2165948827","https://openalex.org/W2170540501","https://openalex.org/W2171220237","https://openalex.org/W2217074939","https://openalex.org/W2294494466","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2035140541","https://openalex.org/W2146381268","https://openalex.org/W7000903450","https://openalex.org/W2071505293","https://openalex.org/W2115690116","https://openalex.org/W4249080379","https://openalex.org/W2091897779","https://openalex.org/W2092375954","https://openalex.org/W2113134943","https://openalex.org/W3171933465"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}