{"id":"https://openalex.org/W1978358353","doi":"https://doi.org/10.1016/j.cbpa.2008.07.013","title":"The impact of enzyme engineering upon natural product glycodiversification","display_name":"The impact of enzyme engineering upon natural product glycodiversification","publication_year":2008,"publication_date":"2008-08-04","ids":{"openalex":"https://openalex.org/W1978358353","doi":"https://doi.org/10.1016/j.cbpa.2008.07.013","mag":"1978358353","pmid":"https://pubmed.ncbi.nlm.nih.gov/18678278","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552347"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbpa.2008.07.013","doi":"https://doi.org/10.1016/j.cbpa.2008.07.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2008.07.013","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552347","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065889110","display_name":"Gavin J. Williams","orcid":"https://orcid.org/0000-0003-2172-9063","observed_orcids":["https://orcid.org/0000-0003-2172-9063"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gavin J Williams","raw_affiliation_strings":["Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, National Cooperative Drug Discovery Program, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, National Cooperative Drug Discovery Program, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016375078","display_name":"Richard W. Gantt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard W Gantt","raw_affiliation_strings":["Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, National Cooperative Drug Discovery Program, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, National Cooperative Drug Discovery Program, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077557326","display_name":"Jon S. Thorson","orcid":"https://orcid.org/0000-0002-7148-0721","observed_orcids":["https://orcid.org/0000-0002-7148-0721"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jon S Thorson","raw_affiliation_strings":["Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, National Cooperative Drug Discovery Program, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Biosynthetic Chemistry, Pharmaceutical Sciences Division, School of Pharmacy, National Cooperative Drug Discovery Program, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, United States","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077557326"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":4510,"currency":"USD","value_usd":4510},"apc_paid":null,"fwci":0.4235,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.46743295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"12","issue":"5","first_page":"556","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.1307000070810318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-engineering","display_name":"enzyme engineering","score":0.7820000052452087},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"protein engineering","score":0.7350000143051147},{"id":"https://openalex.org/keywords/chemoenzymatic-synthesis","display_name":"chemoenzymatic synthesis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/glycosyl-donors","display_name":"glycosyl donors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"substrate specificity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/enzyme-evolution","display_name":"enzyme evolution","score":0.6990000009536743},{"id":"https://openalex.org/keywords/small-molecule-drug-development","display_name":"small molecule drug development","score":0.8550000190734863}],"concepts":[{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.8812496066093445},{"id":"https://openalex.org/C161019410","wikidata":"https://www.wikidata.org/wiki/Q67201373","display_name":"Glycosyltransferase","level":3,"score":0.6525238752365112},{"id":"https://openalex.org/C2780906977","wikidata":"https://www.wikidata.org/wiki/Q2855177","display_name":"Glycosyl","level":2,"score":0.6059051752090454},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.5760504007339478},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5320025086402893},{"id":"https://openalex.org/C9418097","wikidata":"https://www.wikidata.org/wiki/Q440681","display_name":"Directed evolution","level":4,"score":0.5315805673599243},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.5172113180160522},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.47882917523384094},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4708936810493469},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44384855031967163},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.42801323533058167},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4157010316848755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3968321681022644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3194812536239624},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2394234836101532},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016695","descriptor_name":"Glycosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016695","descriptor_name":"Glycosyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.cbpa.2008.07.013","doi":"https://doi.org/10.1016/j.cbpa.2008.07.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2008.07.013","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},{"id":"pmid:18678278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18678278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in chemical biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3524936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552347","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4552347","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552347","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Chem Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3524936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4552347","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1805831874","display_name":"UWCCC National Cooperative Drug Discovery Group for Can*","funder_award_id":"U19CA113297","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3170273731","display_name":null,"funder_award_id":"CA84374","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5328133151","display_name":"STUDIES ON CALICHEAMICIN BIOSYNTHESIS AND SELF RESISTANCE","funder_award_id":"R01CA084374","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W12851679","https://openalex.org/W1596437127","https://openalex.org/W1967960525","https://openalex.org/W1970809419","https://openalex.org/W1972370905","https://openalex.org/W1976609472","https://openalex.org/W1976888209","https://openalex.org/W1982127102","https://openalex.org/W1982621063","https://openalex.org/W1984822819","https://openalex.org/W1987220499","https://openalex.org/W1987736714","https://openalex.org/W1987832085","https://openalex.org/W1991437032","https://openalex.org/W1993576826","https://openalex.org/W1998985805","https://openalex.org/W1999338626","https://openalex.org/W2000462994","https://openalex.org/W2002454461","https://openalex.org/W2005562312","https://openalex.org/W2006724610","https://openalex.org/W2007058385","https://openalex.org/W2008466703","https://openalex.org/W2009887299","https://openalex.org/W2010900403","https://openalex.org/W2011830019","https://openalex.org/W2012004878","https://openalex.org/W2013321576","https://openalex.org/W2020567118","https://openalex.org/W2021704952","https://openalex.org/W2027195517","https://openalex.org/W2032876133","https://openalex.org/W2035483200","https://openalex.org/W2035590565","https://openalex.org/W2036103620","https://openalex.org/W2036344160","https://openalex.org/W2041990029","https://openalex.org/W2042187446","https://openalex.org/W2044777100","https://openalex.org/W2049284881","https://openalex.org/W2049636749","https://openalex.org/W2055952169","https://openalex.org/W2061234740","https://openalex.org/W2061349783","https://openalex.org/W2065245548","https://openalex.org/W2069067280","https://openalex.org/W2069468775","https://openalex.org/W2072256038","https://openalex.org/W2074695441","https://openalex.org/W2077336283","https://openalex.org/W2077646314","https://openalex.org/W2078532751","https://openalex.org/W2079450238","https://openalex.org/W2081239739","https://openalex.org/W2084366893","https://openalex.org/W2090820262","https://openalex.org/W2095225890","https://openalex.org/W2098953534","https://openalex.org/W2105718579","https://openalex.org/W2112921913","https://openalex.org/W2131631910","https://openalex.org/W2131656291","https://openalex.org/W2132287305","https://openalex.org/W2136624548","https://openalex.org/W2141474275","https://openalex.org/W2144968571","https://openalex.org/W2151031764","https://openalex.org/W2151891111","https://openalex.org/W2156675148","https://openalex.org/W2158837823","https://openalex.org/W2950754247","https://openalex.org/W3122425247"],"related_works":["https://openalex.org/W2079505033","https://openalex.org/W2295059153","https://openalex.org/W2011830019","https://openalex.org/W2061025045","https://openalex.org/W7010213883","https://openalex.org/W2775311357","https://openalex.org/W2345822604","https://openalex.org/W2073815736","https://openalex.org/W2300549074","https://openalex.org/W4310466682"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}