{"id":"https://openalex.org/W1978344347","doi":"https://doi.org/10.1016/j.proeng.2011.12.307","title":"A continuous flow \u03bcPCR device with integrated microheaters on a flexible polyimide substrate","display_name":"A continuous flow \u03bcPCR device with integrated microheaters on a flexible polyimide substrate","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1978344347","doi":"https://doi.org/10.1016/j.proeng.2011.12.307","mag":"1978344347"},"language":"en","primary_location":{"id":"doi:10.1016/j.proeng.2011.12.307","doi":"https://doi.org/10.1016/j.proeng.2011.12.307","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.proeng.2011.12.307","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1877705811059765/pdf","source":{"id":"https://openalex.org/S45645249","display_name":"Procedia Engineering","issn_l":"1877-7058","issn":["1877-7058"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Procedia Engineering","raw_type":"journal-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S1877705811059765/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088431483","display_name":"E. Mavraki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"E. Mavraki","raw_affiliation_strings":["Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043819323","display_name":"Despina C. Moschou","orcid":"https://orcid.org/0000-0001-9175-5852","observed_orcids":["https://orcid.org/0000-0001-9175-5852"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Moschou","raw_affiliation_strings":["Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066227196","display_name":"George Kokkoris","orcid":"https://orcid.org/0000-0003-4507-7311","observed_orcids":["https://orcid.org/0000-0003-4507-7311"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"G. Kokkoris","raw_affiliation_strings":["Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074733348","display_name":"Nikolaos Vourdas","orcid":"https://orcid.org/0000-0002-6425-665X","observed_orcids":["https://orcid.org/0000-0002-6425-665X"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N. Vourdas","raw_affiliation_strings":["Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087412002","display_name":"Stavros Chatzandroulis","orcid":"https://orcid.org/0000-0001-9832-7295","observed_orcids":["https://orcid.org/0000-0001-9832-7295"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"S. Chatzandroulis","raw_affiliation_strings":["Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece","institution_ids":["https://openalex.org/I203474044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111873642","display_name":"Angeliki D. Tserepi","orcid":"https://orcid.org/0000-0002-5426-1383","observed_orcids":["https://orcid.org/0000-0002-5426-1383"]},"institutions":[{"id":"https://openalex.org/I203474044","display_name":"National Centre of Scientific Research \"Demokritos\"","ror":"https://ror.org/038jp4m40","country_code":"GR","type":"facility","lineage":["https://openalex.org/I203474044"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"A. Tserepi","raw_affiliation_strings":["Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics, NCSR \u201cDemokritos\u201d, 153 10 Aghia Paraskevi, Greece","institution_ids":["https://openalex.org/I203474044"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111873642"],"corresponding_institution_ids":["https://openalex.org/I203474044"],"apc_list":null,"apc_paid":null,"fwci":1.6603,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.8032722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":null,"first_page":"1245","last_page":"1248"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/continuous-flow-pcr","display_name":"continuous-flow PCR","score":0.7570000290870667},{"id":"https://openalex.org/keywords/flexible-polyimide-substrate","display_name":"flexible polyimide substrate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/heat-transfer","display_name":"heat transfer","score":0.75},{"id":"https://openalex.org/keywords/fluid-dynamics","display_name":"fluid dynamics","score":0.7699999809265137},{"id":"https://openalex.org/keywords/low-cost-microfluidic-devices","display_name":"low-cost microfluidics","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2779426163","wikidata":"https://www.wikidata.org/wiki/Q17123760","display_name":"Microheater","level":4,"score":0.9944700002670288},{"id":"https://openalex.org/C63662833","wikidata":"https://www.wikidata.org/wiki/Q6839341","display_name":"Microchannel","level":2,"score":0.9007261991500854},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7772554159164429},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7686061859130859},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6100183725357056},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.49564826488494873},{"id":"https://openalex.org/C50517652","wikidata":"https://www.wikidata.org/wiki/Q179635","display_name":"Heat transfer","level":2,"score":0.4719589948654175},{"id":"https://openalex.org/C204530211","wikidata":"https://www.wikidata.org/wiki/Q752823","display_name":"Thermal","level":2,"score":0.47099870443344116},{"id":"https://openalex.org/C172120300","wikidata":"https://www.wikidata.org/wiki/Q1134348","display_name":"Volumetric flow rate","level":2,"score":0.4497249126434326},{"id":"https://openalex.org/C151662897","wikidata":"https://www.wikidata.org/wiki/Q610112","display_name":"Heating element","level":2,"score":0.44879332184791565},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35755810141563416},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.15137404203414917},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1198740005493164},{"id":"https://openalex.org/C136525101","wikidata":"https://www.wikidata.org/wiki/Q5428139","display_name":"Fabrication","level":3,"score":0.06453600525856018},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.proeng.2011.12.307","doi":"https://doi.org/10.1016/j.proeng.2011.12.307","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.proeng.2011.12.307","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1877705811059765/pdf","source":{"id":"https://openalex.org/S45645249","display_name":"Procedia Engineering","issn_l":"1877-7058","issn":["1877-7058"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Procedia Engineering","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.proeng.2011.12.307","doi":"https://doi.org/10.1016/j.proeng.2011.12.307","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.proeng.2011.12.307","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1877705811059765/pdf","source":{"id":"https://openalex.org/S45645249","display_name":"Procedia Engineering","issn_l":"1877-7058","issn":["1877-7058"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Procedia Engineering","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G496129201","display_name":null,"funder_award_id":"2007 \u2013 2013","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1978344347.pdf","grobid_xml":"https://content.openalex.org/works/W1978344347.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1969388866","https://openalex.org/W2025177747","https://openalex.org/W2056645539","https://openalex.org/W2146936760","https://openalex.org/W2157459335"],"related_works":["https://openalex.org/W1973651571","https://openalex.org/W2415862844","https://openalex.org/W49684292","https://openalex.org/W2108619628","https://openalex.org/W1978270044","https://openalex.org/W2084301524","https://openalex.org/W2044366283","https://openalex.org/W2167616436","https://openalex.org/W1921181878","https://openalex.org/W3212858200"],"abstract_inverted_index":{"The":[0],"purpose":[1],"of":[2,78,86,114,138],"this":[3],"work":[4],"is":[5,141],"to":[6,26,37,133,144],"develop":[7],"a":[8,19,57,64],"simple":[9],"and":[10,42,50,69,75,121,126],"low":[11],"cost":[12],"microfluidic":[13,60],"device":[14],"with":[15],"integrated":[16,80],"microheaters":[17,116],"on":[18,30,63,72],"thin":[20],"flexible":[21],"polymeric":[22],"substrate,":[23],"in":[24,146],"order":[25],"perform":[27],"DNA":[28,94],"amplification":[29,34],"chip,":[31],"at":[32],"faster":[33],"rates":[35],"due":[36],"the":[38,48,51,73,79,87,93,107,112,115,136,147,150],"reduced":[39],"thermal":[40,76,122,152],"capacity":[41],"large":[43],"heat":[44],"transfer":[45,125],"rate":[46],"between":[47],"sample":[49,95],"temperature-controlled":[52],"heating":[53],"zones.":[54],"We":[55],"fabricate":[56],"continuous-flow":[58],"PCR":[59],"device,":[61],"developed":[62],"commercially":[65],"available":[66],"substrate":[67],"(PyraluxTM)":[68],"we":[70],"focus":[71],"electrical":[74],"characterization":[77],"microheaters.":[81],"Each":[82],"microheater":[83,140],"defines":[84],"one":[85],"three":[88],"temperature":[89,119,137],"zones":[90],"through":[91,106],"which":[92],"will":[96],"be":[97],"cycled":[98],"for":[99],"25":[100],"times":[101],"as":[102,118],"it":[103],"flows":[104],"continuously":[105],"microchannel.":[108],"Electrical":[109],"measurements":[110],"confirm":[111],"functionality":[113],"both":[117],"sensors":[120],"elements.":[123],"Heat":[124],"fluid":[127],"dynamics":[128],"computations":[129],"are":[130],"also":[131],"performed":[132],"ascertain":[134],"that":[135,145],"each":[139],"almost":[142],"identical":[143],"microchannel":[148],"crossing":[149],"corresponding":[151],"zone.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
